LINC00511
Contents
Annotated Information
Approved Symbol
LINC00511
Approved Name
long intergenic non-protein coding RNA 511
Synonyms
onco-lncRNA-12
Chromosome
17q24.3
RefSeq ID
NR_033876
Ensembl ID
ENSG00000227036
Function
LINC00511 binds histone methyltransferase enhancer of zeste homolog 2 ((EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), a highly conserved protein complex that regulates gene expression by methylating lysine 27 on histone H3).[1] LINC00511 is mechanistically, functionally, and clinically oncogenic in NSCLC (non-small-cell lung cancer).[1]
Sequence
>gi|299829299|ref|NR_033876.1| Homo sapiens long intergenic non-protein coding RNA 511 (LINC00511), long non-coding RNA
000001 AAGGGGCGAT GCGCCCCGGA GGGGGAGGGA CGCAAGGGGC GACTACTGTT ACCTCGCTTG GAGATACCAA GGCCGGTCGG 000080
000081 ACCCCCCGCT GGCCGAATGT GGGGAGCGAG CAGATCCAGC CTGTTTGGAC GTGGTGAGGA CCCAGCCGTG GGGTTTAAGG 000160
000161 CCAAGTTAGC CTCTCCCTTC ACTGATTACA AGAGCCATTG TTACAGGTGC TCACATGCCA GGAGAAATAA GCTGGTGATT 000240
000241 TATGTGGCAC AGCACCATCG ATCGACCTAC AAAGGAAGCT TCAGTGCAGC CGTGTTGCTA TACAGACCTC TCTCACCAAG 000320
000321 GCGTCATGAA CTGAAGGGCT GGGAGAGGCC TCGTGGAGGA GGAAGAGTTT CGCTCAGCTG CTTGGGTGTG GGACTGAATG 000400
000401 TGGTTCCAGA ACTGGTCGCT GCCTTCACCC GCTGACTCTG GTCTCGGCGA TGACAAGCCC ATGGAACAGA CTTACGGCGT 000480
000481 ATGACCTCAT CGGAGACTTG TACATGGGGC CAACCCCCAT TTTCCCACAG GAAACCCACA CTCTAATTAA GGGCTGACCC 000560
000561 TGAACTTGAA TCTGAGTCTT CTCTTTCTTC AACAGAGAGC CATCTCTCCA GCCCAGCTGG CAAGGAGACA GGTGATGTTA 000640
000641 CAGGAAAAAA TACACAGCTT GTGCCCTTGG AATTACCAGA GTTCAAAGCC TGTTCAGCAT CTACCCACCA TGTGACCCGG 000720
000721 GTCGAATTCT TCAGTTTCTC TAAGCCCATT TTCTCATCTG TAAGATGGGG AAGTGTAATC AGTTCTGAAC CCACATATAC 000800
000801 CTCACTGGGC TTGAACAGGC CTGAGCAGGC ATGTGGGGCT TTACTAGCTA GCCATCCTTT CTGCCGCTCT CCCTCATTCT 000880
000881 CCTTCAAGCC CCCCAAAGTC CTTGGTGGAG GAGGAAGTGG AGACAGAACG TTTGGTGTTG GGTGAGGTAC GTGAGGAGGC 000960
000961 TGATTTCAGA ACCTCCAGGA AACAAAGCTT TAGTGTTCCG AGGGCAGTGC CCGCCTGTGC CTCCTCCTCA CAGGGGGTAG 001040
001041 TAGGAGTGGG GTGGGGCCGA GGCATTTCCC AGCACAGCTC AATCACATCT CCTGCGCCTG CCCTTGTGAC CTGCTCACTG 001120
001121 GAAAGGAAGA AATGACCGAG GGAGAAGGGA GGGCATTTGA GGGGAGAAGA AGAGGATGGA GAAAAAAACT GGATCATCTC 001200
001201 GTGACATGGA AAGAAAGGTC TGAGCTCTGA CGATCCCCTC ACGTGATTAT AGGCATGAGG ACTCACTCTT CGAATTGTTT 001280
001281 GAAAATTGAA TGGACTGGCT CACACCTTCT GAAATTTCTT GGAAGCTCTG GAGTAACTAT TCCACTAAAG AACAGCGTGT 001360
001361 TTTTGGCTGA AATCTGTGAC TGTTTGTTTT TGAGTTATTT TAATCTCTGT GTCAAGCATG AAAACCTCAG CAGCCTGGGA 001440
001441 TTTATAATTA GATCCCACTG GCATGCCCTC TCACCTCTCA AACATGCCAC AGTGCTTTGG CTCTCTCCTT GTGCAAACCT 001520
001521 CCCTTTGATA TTTTTGGATA TCGATACCAA GTGTATCTGC ATATTTTAAC CAACTGATAT GCATATCCTG TGATCTGAGG 001600
001601 CATTCGCTCA ATGTGGGGCA TCAGGCCAGC TGTGAACTTC CTTTAAAATT TATTTTGTGT CAAATGATTC CCTAATGCTA 001680
001681 TAGCTCCCTT GAACTGCTAG ATTTATGAAA ATTCTGCACA ACACATAGCT CAGAGAAAAA AAAAAAAGAG TGTTGCAAGA 001760
001761 CCAGATATAG GATATCATTT GATTTGTTTA AAACACTCTG TCCAGGGGGT TTTGACTTGC TAATTTAAAA ATAATTCTAA 001840
001841 AATTAGGTAC AGTTGACCCT TAGTATCCAT GGGGGATTGG TTCCAGGATG CCCTGTGGAT ACCAGAATCC AAGGATGCTC 001920
001921 AAGTTCCTGA CATAAATGGC TTAGTGTTTG CATATAACCT ACTCCCCTCT TCCTATATAC TTTAAATAAT CTCTAGATTA 002000
002001 CTTATAATGC CTAACACAAC GCCTGTGCAT CACTTCATTC ATGTGGATTC AATGTAGTAC TTGGTGTGAA GAAAATTTAA 002080
002081 GTCTTGCTTT TTGGAACTTT GTGGATTTTT TTTTCTGGAA TGTTTTTGAT CTGCAGTTGG TTGAATCCAC AGGTGCAGAA 002160
002161 CTATGGACAC AGGGGGCTGA CTATGTATAT TTATATCCAC TTGCAAAATT AAGAATAAAA ATAATGTGCA TCAGCAGGTG 002240
002241 CAGATTCTGA TGCTCGGTGG ACAGT
000081 ACCCCCCGCT GGCCGAATGT GGGGAGCGAG CAGATCCAGC CTGTTTGGAC GTGGTGAGGA CCCAGCCGTG GGGTTTAAGG 000160
000161 CCAAGTTAGC CTCTCCCTTC ACTGATTACA AGAGCCATTG TTACAGGTGC TCACATGCCA GGAGAAATAA GCTGGTGATT 000240
000241 TATGTGGCAC AGCACCATCG ATCGACCTAC AAAGGAAGCT TCAGTGCAGC CGTGTTGCTA TACAGACCTC TCTCACCAAG 000320
000321 GCGTCATGAA CTGAAGGGCT GGGAGAGGCC TCGTGGAGGA GGAAGAGTTT CGCTCAGCTG CTTGGGTGTG GGACTGAATG 000400
000401 TGGTTCCAGA ACTGGTCGCT GCCTTCACCC GCTGACTCTG GTCTCGGCGA TGACAAGCCC ATGGAACAGA CTTACGGCGT 000480
000481 ATGACCTCAT CGGAGACTTG TACATGGGGC CAACCCCCAT TTTCCCACAG GAAACCCACA CTCTAATTAA GGGCTGACCC 000560
000561 TGAACTTGAA TCTGAGTCTT CTCTTTCTTC AACAGAGAGC CATCTCTCCA GCCCAGCTGG CAAGGAGACA GGTGATGTTA 000640
000641 CAGGAAAAAA TACACAGCTT GTGCCCTTGG AATTACCAGA GTTCAAAGCC TGTTCAGCAT CTACCCACCA TGTGACCCGG 000720
000721 GTCGAATTCT TCAGTTTCTC TAAGCCCATT TTCTCATCTG TAAGATGGGG AAGTGTAATC AGTTCTGAAC CCACATATAC 000800
000801 CTCACTGGGC TTGAACAGGC CTGAGCAGGC ATGTGGGGCT TTACTAGCTA GCCATCCTTT CTGCCGCTCT CCCTCATTCT 000880
000881 CCTTCAAGCC CCCCAAAGTC CTTGGTGGAG GAGGAAGTGG AGACAGAACG TTTGGTGTTG GGTGAGGTAC GTGAGGAGGC 000960
000961 TGATTTCAGA ACCTCCAGGA AACAAAGCTT TAGTGTTCCG AGGGCAGTGC CCGCCTGTGC CTCCTCCTCA CAGGGGGTAG 001040
001041 TAGGAGTGGG GTGGGGCCGA GGCATTTCCC AGCACAGCTC AATCACATCT CCTGCGCCTG CCCTTGTGAC CTGCTCACTG 001120
001121 GAAAGGAAGA AATGACCGAG GGAGAAGGGA GGGCATTTGA GGGGAGAAGA AGAGGATGGA GAAAAAAACT GGATCATCTC 001200
001201 GTGACATGGA AAGAAAGGTC TGAGCTCTGA CGATCCCCTC ACGTGATTAT AGGCATGAGG ACTCACTCTT CGAATTGTTT 001280
001281 GAAAATTGAA TGGACTGGCT CACACCTTCT GAAATTTCTT GGAAGCTCTG GAGTAACTAT TCCACTAAAG AACAGCGTGT 001360
001361 TTTTGGCTGA AATCTGTGAC TGTTTGTTTT TGAGTTATTT TAATCTCTGT GTCAAGCATG AAAACCTCAG CAGCCTGGGA 001440
001441 TTTATAATTA GATCCCACTG GCATGCCCTC TCACCTCTCA AACATGCCAC AGTGCTTTGG CTCTCTCCTT GTGCAAACCT 001520
001521 CCCTTTGATA TTTTTGGATA TCGATACCAA GTGTATCTGC ATATTTTAAC CAACTGATAT GCATATCCTG TGATCTGAGG 001600
001601 CATTCGCTCA ATGTGGGGCA TCAGGCCAGC TGTGAACTTC CTTTAAAATT TATTTTGTGT CAAATGATTC CCTAATGCTA 001680
001681 TAGCTCCCTT GAACTGCTAG ATTTATGAAA ATTCTGCACA ACACATAGCT CAGAGAAAAA AAAAAAAGAG TGTTGCAAGA 001760
001761 CCAGATATAG GATATCATTT GATTTGTTTA AAACACTCTG TCCAGGGGGT TTTGACTTGC TAATTTAAAA ATAATTCTAA 001840
001841 AATTAGGTAC AGTTGACCCT TAGTATCCAT GGGGGATTGG TTCCAGGATG CCCTGTGGAT ACCAGAATCC AAGGATGCTC 001920
001921 AAGTTCCTGA CATAAATGGC TTAGTGTTTG CATATAACCT ACTCCCCTCT TCCTATATAC TTTAAATAAT CTCTAGATTA 002000
002001 CTTATAATGC CTAACACAAC GCCTGTGCAT CACTTCATTC ATGTGGATTC AATGTAGTAC TTGGTGTGAA GAAAATTTAA 002080
002081 GTCTTGCTTT TTGGAACTTT GTGGATTTTT TTTTCTGGAA TGTTTTTGAT CTGCAGTTGG TTGAATCCAC AGGTGCAGAA 002160
002161 CTATGGACAC AGGGGGCTGA CTATGTATAT TTATATCCAC TTGCAAAATT AAGAATAAAA ATAATGTGCA TCAGCAGGTG 002240
002241 CAGATTCTGA TGCTCGGTGG ACAGT
Labs working on this lncRNA
- Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan, P. R. China.
References
- ↑ 1.0 1.1 Sun CC, Li SJ, Li G, Hua RX, Zhou XH, Li DJ. Long Intergenic Noncoding RNA 00511 Acts as an Oncogene in Non-small-cell Lung Cancer by Binding to EZH2 and Suppressing p57. Mol Ther Nucleic Acids. 2016 Nov 15;5(11):e385. doi: 10.1038/mtna.2016.94. PubMed PMID: 27845772; PubMed Central PMCID: PMC5155326.
