CPNE8-AS1
LncRNA CPNE8-AS1 is a potent biomarker for cervical cancer (CC) progression.
Contents
Annotated Information
Name
CPNE8-AS1: CPNE8 antisense RNA 1 (HGNC nomenclature).
Alias
RP11-396F22.1 [1]
Characteristics
CPNE8-AS1 located on chromosome 12 is a 526 bp-long lncRNA that is transcribed in antisense orientation from intron [1].
Function
CPNE8-AS1 overexpression reduces overall survival time and tumor-free survival time, compared to underexpression of RP11-396F22.1, which suggests that CPNE8-AS1 might be the molecular marker for predicting lymph node metastasis and evaluating prognosis in early CC. Moreover, in vitro researches indicate that knockdown of CPNE8-AS1 inhibits proliferation and migration of CC cells and increases G2/M cell cycle arrest and apoptotic rate [1].
Regulation
Please input information here.
Diseases
Expression
CPNE8-AS1's expression has been observed to significantly increase in CC tissues and decreased in adjacent tissues (cervical stroma and muscular layer) [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-GCAAGAACTGAGACCTGACG- 3' | 5'-TAAGCACACCACTCCACTGC- 3' [1] |
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Second Road 58, Guangzhou 510080, Guangdong, P. R. China. [1] [2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Huang J, Liu T, Shang C, Zhao Y, Wang W, Liang Y, Guo L, Yao S. Identification of lncRNAs by microarray analysis reveals the potential role of lncRNAs in cervical cancer pathogenesis. Oncology letters. 2018, 15(4):5584-92.
- ↑ 2.0 2.1 Zhao Y, Huang J, Liu T, He S, Shang C, Guo L, Du Q, Yao S. Overexpression of long non-coding RNA RP11-396F22. 1 correlates poor prognosis of patients with early-stage cervical cancer. American journal of translational research. 2018, 10(3):684.
Sequence
>gi|107984504|ref|XR_001749083.2| Homo sapiens CPNE8 antisense RNA 1 (CPNE8-AS1), long non-coding RNA
000081 CGCGGGGATC CCGGTTTCCC AGCCCCCTTC CGGCAGGCAG CAGCCCGGGC GGGGGACACA CTCCGTGATC CCCTCCTGGC 000160
000161 TGGAGGGGTC AGGCTTGGTG GACCCAGCAA GCAGCCTGAT GGAGAAGGTG GCACCAGACG CAGACCCCTA CCGTCCAGGA 000240
000241 CCGCAAGCCC TCGCCGGCTC TGCGTGCTTT TAGGTTTTGT CTCCACCTCT GCACACCCAC ACTCGCCTCC TGGGCCGCGA 000320
000321 CAGCTTCCTT CTGTCAATCA GGTGTGGACG GGAAGGTCTC GAAGTTTCCT CGCCTGAGTT GAAAGCTGGA GGTGGGGGCA 000400
000401 CCTCTGCCCG TTCCTAACTG CCCCGTTATA AGGTCCCCCT CCCCACAATT GGTTCTCACC TCGCCCTCGG AGCTCTTGGG 000480
000481 AGATCCCTCC GTCCCTCCTA CTGTGCCCTC GGGCAGATGA GTCTGGTCCC AGCTTCTGGA CTGCCCACTG TCGGCCACTT 000560
000561 GAGAGTTGGG GACGGTGGGG CATTGTGACG CTCTCCAACC TTGGAACACG GTGGCAAAGT GGCCGATCAA TATATGGGAC 000640
000641 AAGTGGGGGC GGGGGGGCGG ACTCTAAGGT GGAAAAAACA ATACTACTTG GGATTTAAGG AAGCAATCTG GATTCTGTCT 000720
000721 CCCCTTGGTT CTTCGGAGCT TAGAGGTCTA ACGGCGACAT TCCTCCTACA GTAAGGGCTC TTCTGGGTCC CTCGTTTCCA 000800
000801 AAGGCATGAA AGTTCTGACC TGAAAATGGG GGCCGGGGAG GGTGATGTCA CAACCATATA ACGCAGCTCC TTCAGCCGAC 000880
000881 TCCCACCCGC AAGAACTGAG ACCTGACGGA TAAAAGCAGA GAGGAGTCAG AGTGAGCGCT GCGTTTGGGA AACTGCATTC 000960
000961 CAGGGCAGCA AGACTGGTGC CAAGACGGAG TCGTGGCAAA AGCATCCGGA GGTCTTCCTT AATATATGTC AGCAGTGGAG 001040
001041 TGGTGTGCTT AAGGAGAGAG AGACTTGGAA AAATACAGAC CGAGAACAAG GCCATGTGGA GATAGAGGCA GAGACTGAAG 001120
001121 TTGTACCACC AAAGGCAAAG AATATCAAGT ATTATCAGTA ACCACAGGAA GCTGGAAGAG GCCAGGAAAG GTTTTTCTTA 001200
001201 GAGACCTTGG AAGGAGCCTG ACCCTGGAAC ACCTTGATTT TAGACTTCTG ACCCTCAAAA TTGTGAAAGA ATAAATTTCT 001280
001281 GTTGTTTTAA GCAA
