LINC01121

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LINC01121, Inhibits Cell Apoptosis While Facilitating Proliferation, Migration, and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via GLP1R

Annotated Information

Approved Symbol

LINC01121

Approved Name

LINC01121: long intergenic non-protein coding RNA 1121, UNQ6975

Characteristics

LINC01121 is determined to be located on chromosome 2p21, with indications that solute carrier family 3, member 1 (SLC3A1) share the same genetic locus with LINC01121 [1].

Function

LINC01121 influences the growth and apoptosis of pancreatic cancer cells by targeting GLP1R via the cAMP/PKA signaling pathway, in a bid to unearth an effective therapy for pancreatic cancer[1]. LINC01121 induces cell cycle arrest and inhibits apoptosis in pancreatic cancer cells and PANC-1 cells [1].

Regulation

NA

Diseases

  • Pancreatic cancer [1].

Expression

LINC01121 is highly expressed in pancreatic cancer [1].

Labs working on this lncRNA

  • Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  • Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China
  • Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Qian YG, Ye Z, Chen HY, Lv Z, Zhang AB, Fan L et al. LINC01121 Inhibits Cell Apoptosis While Facilitating Proliferation, Migration, and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via GLP1R[J]. Cell Physiol Biochem. 2018, 47(3):1007-1024

Sequence

>gi|400952|ref|NR_033831.1|Homo sapiens long intergenic non-protein coding RNA 1121 (LINC01121), long non-coding RNA

000001 TGGAAATGCT GGGCCCTTCG AGGTTAGCTT AAACTGAAGA GAGGAACTTG GTTAGAATAC AGACATCTCT GATGCTGTGT 000080
000081 CCCGGATGTT GAGCTTCCAG CTCTGATGGC ACGTTCTGTC AACTCAGCTC TGTTTTGAGT GGAACTGAAC ACTCAGTGAT 000160
000161 GGCTAAAAAC AGCAGTTGAC TAAACTAATT AAGCTACATG TAGACGGTGA CGGAGGCGGA AAGATAGGCC GAGACAGGCC 000240
000241 CTTTGGAAAT TATCCTGAGC ATTCTTCTTT TACAGAAGAA CAGTAAAACA GACTTGTTAT TGGCAGCCCA TTAGTGCTCA 000320
000321 GGAGAGGCGG TCTCCAGCAT GACATCAGCC GGCGGCTCGA CCCAAATCTA GTATTTCACC AGAGAGCCTA ACGCTGCTGG 000400
000401 CTTTCCAACT GTGTGGAAGA CAAAATAGCG AACAGCTATT ACATATCTGG ACTCGGTCTG CGCAAACCAC TTCAAGCCAC 000480
000481 AGCAAAGGAG GCGGCCTTCC AGCCTTGAGC CTGTAGAAGG TTCATGAATG GAAACCTGGA TGGATGGGTT GTGGTCTTGG 000560
000561 CCGCTCCACT TCTGCCTGCA GCCCAGGAGG GGGGCCCTGT GTCTCCTGCT CAGGCCTGCA CAGGATACAG GCGTAACAAA 000640
000641 GACAAGGATG AAATAAGTCC TGTGATGGAG AGACAAGCAA AATTCTACCT GACTTCACAG GAGGAAGAAG TGTGCTGTGC 000720
000721 CAGGGGGAAC AGGAGAAAGC TTCATGGAAG AGGTCACAGG AAATGGGTAG CTATCCAGCT AAATAGATTT CATGCTTGAC 000800
000801 TTCAGTGGAA TAGCTCAAAT GATGATCTGT TTGGGAGAGT AAATTAAAGA GTTTCCATCC GAGGTTGGTT GAATCCACAG 000880
000881 ATACGGAACC CACAGATATA GAGGGCCAAC CATACTGAGT CCTGACTTCA CCCATTCCTT CTACCCCCAT CTCTCCTAAT 000960
000961 CCTTAAACTT CCTTGCAATT CCTGGAGCAG AATACTCGTG TAGGAGTCAG GGGTTGTCTT CCCTTCCTAG AAGCAATGCT 001040
001041 TCTATGTTCT CATTTGATGT TGAATAAAAC ATTAAACAGA AAAGCTTTGA TAACATCAAA AAAAAAAAAA AAAA
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