EGILA
LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2),one kind cytoplasmic long non-coding RNA,was up-regulated in glioma and was quite correlated with poor prognosis of glioma patients.
Contents
Annotated Information
Name
Approved symbol:EGILA
Approved name:EGFR interacting lncRNA
HGNC ID :HGNC:54482
Characteristics
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Function
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion [1].
Regulation
Lnc-EGFR links an immunosuppressive state to cancer by promoting Treg cell differentiation[2].
Expression
Nc-EGFR specifically binds to EGFR and blocks its interaction with and ubiquitination by c-CBL, stabilizing it and augmenting activation of itself and its downstream AP-1/NF-AT1 axis, which in turn elicits EGFR expression[2].
Diseases
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Labs working on this lncRNA
- Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province 210029, P.R. China[2].
- Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, Jiangsu Province 210029, P.R. China[2].
- Metabolomics Shared Resource, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawaii 96813, USA[2].
- Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, Hawaii 96813, USA.[2].
References
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedref - ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Jiang R, Tang J, Chen Y, Deng L, Ji J, Xie Y, Wang K, Jia W, Chu WM, Sun B. The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nat Commun. 2017 May 25;8:15129. doi: 10.1038/ncomms15129.
