EMSLR
Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.
Contents
Annotated Information
Name
Approved symbol:EMSLR
Approved name:E2F1 mRNA stabilizing lncRNA
HGNC ID:54408
Alias symbols:EMS
RefSeq ID:NR_110115
Characteristics
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Function
EMS functions as an oncogenic molecule by promoting G1/S cell cycle progression [1].
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].
Regulation
EMS is able to connect c-Myc to cell cycle control and tumorigenesis via modulating E2F1 mRNA stability[2].
Expression
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Diseases
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Labs working on this lncRNA
- Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China[2].
- Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China[2].
- Department of Thoracic Surgery, First Affiliated Hospital of USTC, USTC, 230027 Hefei, Anhui, China[2].
- Department of Laboratory Medicine, First Affiliated Hospital of USTC, USTC, 230027 Hefei, Anhui, China[2].
- Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China; meiyide@ustc.edu.cn.[2].
