FAM99A
The alterations in the lncRNA family with sequence similarity 99 member A (FAM99A) in PE and its effects on trophoblasts.
Contents
Annotated Information
Name
Approved symbol:FAM99A
Approved name:family with sequence similarity 99 member A
HGNC ID:HGNC:32368
Previous name:family with sequence similarity 99, member A|family with sequence similarity 99, member A (non-protein coding)|family with sequence similarity 99 member A (non-protein coding)
Alias symbol:FLJ42833
RefSeq ID:NR_026643
LncBook ID:[1]
Characteristics
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Function
FAM99A may serve a role in modulating the functions of trophoblasts, partially via targeting Wnt/β catenin signaling. [1].
EMS cooperates with the RNA binding protein RALY to stabilize E2F1 mRNA, and thereby increases E2F1 expression[1].
Regulation
Overexpression of FAM99A promoted invasion and migration of HTR 8/SVneo cells; conversely, knockdown of FAM99A suppressed the invasive and migratory abilities of HTR 8/SVneo cells.[2].
Expression
FAM99A overexpression induced a decrease in the apoptotic rate of cells, whereas knockdown of FAM99A increased the apoptotic rate of HTR 8/SVneo cells. [2].
Diseases
- Preeclampsia (PE)[2].
Labs working on this lncRNA
- Obstetrics and Gynecology Intensive Care Unit, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[2]
- Department of Obstetrics, The Northwest Women and Children's Hospital, Xi'an, Shaanxi 718900, P.R. China.[2]
References
- ↑ 1.0 1.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedref - ↑ 2.0 2.1 2.2 2.3 2.4 He T, Qiao Y, Lv Y, Wang J, Hu R, Cao Y. lncRNA FAM99A is downregulated in preeclampsia and exerts a regulatory effect on trophoblast cell invasion, migration and apoptosis. Mol Med Rep. 2019 Aug;20(2):1451-1458. doi: 10.3892/mmr.2019.10350. Epub 2019 Jun 5.
