SOX9-AS1
The long non-coding RNA (lncRNA) SOX9 antisense RNA 1 (SOX9-AS1) ,a neighbor gene to SOX9,regulates HCC progression through SOX9 and the Wnt/β-catenin pathway.[1][2]
Contents
Annotated Information
Name
Approved symbol：SOX9-AS1
Approved name：SOX9 antisense RNA 1
HGNC ID：49321
Alias symbol：FLJ37644
RefSeq ID：NR_103738
LncBook ID：HSALNG0118528
Characteristics
location:17q24.3
Function
SOX9-AS1 aggravates HCC progression and metastasis in vitro and in vivo.[2] A SOX9-AS1/miR-5590-3p/SOX9 positive feedback loop drives tumor growth and metastasis in HCC through the Wnt/β-catenin pathway.[2]
Regulation
SOX9-AS1 regulates SOX9 and its known downstream Wnt/β-catenin pathway so as to facilitate epithelial-to-mesenchymal transition. [2] SOX9-AS1 sponges miR-5590-3p to elevate SOX9 expression, and that SOX9 in turn transcriptionally activates SOX9-AS1. [2]
Expression
SOX9-AS1 is upregulated in HCC, and its expression is positively correlated with that of SOX9.[2]
Disease
Hepatocellular carcinoma (HCC)[2]
Labs working on this lncRNA=
- Musculoskeletal Pathology Group, Institute IDIS, Travesia choupana s/n, Hospital Clínico Universitario de Santiago, Santiago de Compostela, 15706, Spain.[1]
- Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.[1]
- Skeletal Research Group, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.[1]
- Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.[1]
- Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.[2]
- Department of Hepatobiliary Pancreatic Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan, China.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA. The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development. 2017 Dec 15;144(24):4510-4521. doi: 10.1242/dev.152504. Epub 2017 Oct 30. PMID: 29084806; PMCID: PMC5769619.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Zhang W, Wu Y, Hou B, Wang Y, Deng D, Fu Z, Xu Z. A SOX9-AS1/miR-5590-3p/SOX9 positive feedback loop drives tumor growth and metastasis in hepatocellular carcinoma through the Wnt/β-catenin pathway. Mol Oncol. 2019 Oct;13(10):2194-2210. doi: 10.1002/1878-0261.12560. Epub 2019 Aug 31. PMID: 31402556; PMCID: PMC6763786.
