PXN-AS1

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LncRNA PXN-AS1 is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]

Annotated Information

Name

Approved symbol:PXN-AS1

Approved name:PXN antisense RNA 1

HGNC ID:44123

Previous name:PXN antisense RNA 1 (non-protein coding)

Alias symbol:EyeLinc4

RefSeq ID:NR_038924

LncBook ID:HSALNG0094500

Characteristics

PXN-AS1-L is upregulated in NPC tissues and cell lines.[1]

Function

PXN-AS1-L interacts with SAPCD2 mRNA 3'-untranslated region, prevents the binding of microRNAs-AGO silencing complex to SAPCD2 mRNA, and upregulates the mRNA and protein level of SAPCD2.[1]

Expression

Overexpression of PXN‐AS1‐L promotes nasopharyngeal carcinoma cell proliferation, migration, and invasion.[1]

PXN-AS1-L overexpression promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L silencing suppresses NPC cell proliferation, migration, and invasion in vitro.[1]

Regulation

LncRNA PXN-AS1-L is upregulated in NPC and promoted NPC malignancy by upregulating SAPCD2 via direct RNA-RNA interaction.[1]

Diseases

Nasopharyngeal carcinoma (NPC) malignancy[1]

Labs working on this lncRNA

  • Department of Otolaryngology, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]
  • Department of Radiotherapy, Henan Province People's Hospital of Henan University, Zhengzhou, China.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Jia X, Niu P, Xie C, Liu H. Long noncoding RNA PXN-AS1-L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2. Cancer Med. 2019 Aug;8(9):4278-4291. doi: 10.1002/cam4.2227. Epub 2019 Jun 7.