Lnc-EVX1-12:1

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Annotated Information

Transcriptomic Nomeclature

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Function

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Regulation

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Expression

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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Basic Information

Transcript ID	lnc-EVX1-12:1
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	483 nt
Genomic location	chr7+:27135742..27139584
Exon number	,
Exons	,
Genome context
Sequence	000001 AAAAGTTTGC CGGCTTCCGC AGTGATGGAT CACCGTTTTA GTGGCATTTA AATCCCCGGC GCTCCGCCGT CTAGGTGACG 000080 000081 CGCAGTCGCC CCCCCAGGCA GCCTAGGCGG CGGCAGCTGC TGCGGCGACT GCAAAGGCCG ATTTGGAGTG CTGGAGCGAA 000160 000161 GAAGAGCAAA AGCTGCGTTC TGCGCGCGCC CGACTCCGCT GCCCGCCCCG CCAGGCCTCC GGGAGGTGGG GGCTGGGAGG 000240 000241 CGTCCCCCGC TCCCGCCCCC TCCCCACCGT TCAATGAAAG ATGAACTGGC GAGAGGTCTG TTTTGCCTGA ACCCATCAAC 000320 000321 AGCTGGGAGA TTAATCAACC ACACTGAAAA TGTGGAGGGA TTTATGGGGG AGGGGGTTGA AATGTGGGTG TTTGAAACAA 000400 000401 AAGTGTATAA ACAAATGAAT TGTTGATAAC TTAGTTATTG ACCTGGAGAC TGGTAGCTTA TTAAAGAAAC TCCGTGTTAC 000480 000481 TCA

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Annotation (From lncRNAdb)

[lnc-EVX1-12:1]

Section	Description
ID	HOTAIRM1
Characteristics	Bidirectional transcript with HoxA1. Located between HOXA1 and HOXA2 genes (Sessa (2007), Sasaki (2007), Zhang (2009)). Identified transcript is 483 nt (Zhang (2009)) but other splice isoforms are also likely to be expressed.
Expression	Expressed in the myeloid lineage (Zhang (2009)). Has also been identified as showing a similar expression pattern to HoxA1 and A2 with expression in thymus, muscle, colon, lung, kidney, spleen etc (Sessa (2007), Sasaki (2007)). Induced by retinoic acid (RA) (Sessa (2007), Zhang (2009)). Shows collinear regulation of expression like HOX PTC genes (Sessa (2007)). Expressed in mouse embryonic stem cells (ESCs) (Guttman (2011))
Function	HOTAIRM plays a role in the regulation of gene expression during RA-induced myeloid differentiation (Zhang (2009)). Knock-down of HOTAIRM prevented induction of HOXA1 and HOXA4 expression during myeloid differentiation as well as the induction of myeloid differentiation genes CD11b and CD18 (Zhang (2009)). Found to interact with a number of of chromatin binding proteins/complexes in mouse embryonic stem cells including PRC1, PRC2 and CBX1 (Guttman (2011)).
Conservation	Sequence quite highly conserved in mammals, with transcripts also detected in mouse and rat (Zhang (2009)).
Name	HOTAIRM1: HOX antisense intergenic RNA myeloid 1

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