NONHSAT011777

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Annotated Information

Name

PRINS: Psoriasis susceptibility-related RNA Gene Induced by Stress.

Characteristics

~3.6 kb, transcribed by RNA Polymerase II; spliced (2 exons) and polyadenylated (Sonkoly (2005)).

Function

siRNA knock-down shows that PRINS is required for cell viability after serum starvation (Sonkoly (2005)), and also alters cell morphology and gene expression (Szegedi (2010)). Elevated PRINS expression in the epidermis is suggested to contribute to psoriasis susceptibility (Sonkoly (2005)). In keratinocytes PRINS regulates the expression of the G1P3 gene, an anti-apoptotic protein that is overexpressed in psoriasis (Szegedi (2010)), although the mechanism is unknown.

Expression

Elevated expression in psoriatic epidermis. Regulated by the proliferation and differentiation state of keratinocytes (Sonkoly (2005)). Expressed at different levels in various human tissues, with highest levels detected in veins (Sonkoly (2005)). Several stress signals such as ultraviolet-B (UV-B) irradiation, viral infection (herpes simplex virus), and translational inhibition increased the RNA level of PRINS (Sonkoly (2005)), as well as HaCaT keratinocyte cell treatment with microbial agents such as bacteria peptidoglycan, lipopolysaccharide (LPS) and wall extract (Bari (2011)).

Conservation

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Misc

PRINS RNA contains contains two Alu elements, as well as a short sequence stretch with ~70% similarity to an element in a small cytoplasmic noncoding RNA, named G8, from Tetrahymena thermophila, whose expression responds to heat shock and is involved in thermotolerance (Sonkoly (2005)).

Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	NONHSAT011777
Source	NONCODE4.0
Same with	,
Classification	intronic(S)
Length	2199 nt
Genomic location	chr10+:24536054..24544975
Exon number	2
Exons	24536054..24537320,24544051..24544975
Genome context
Sequence	000001 GGCCTTTTTT TTTTTTTTTT TCAAATGCCC CTTTCATTAT GAAACTCTTT TTTAACTTTT AATTTAAGTT CAGGGGTATG 000080 000081 TGTGCAGATT TGTTACATAG GTAAACTTGT GTCATGGGGC TTTGTTGTAC AGGTTGTTTC ATCACCCAGG TATTATTTTA 000160 000161 TTTTCATTTT AGTTTTTTAA ATTTCTTTTT AGAGGCGGGG TCTCACTGTG TTTTGCCCAG GCTGGTCTCG AACTCCTCCT 000240 000241 GGTCTCAAGC AATCCTCTCG CCTCTGCCTC CCCAAGTGTT GGGATTATAG GCATGAGCTA CTGCACTCAG CCCACCATTT 000320 000321 GTTTTAAAAA GGGTGGATCC TATTTGTATA AAAAGCCATG TGCATTTTCT GTGTACTTGT CTACACATTA ATTTCCAGGC 000400 000401 TGGGCGTGGT GGCTCACGCT TGTAATCCCA GCACTTTGGG AGGCCAAGGG GAGGCAGATC ATGAGGTTAG GAGATCGAAA 000480 000481 CCATCCTGGC TAACACGGTG AAACCCCGTC TCTACTAAAA ATACAAAAAC AAAATTAGCA GGGTGTTGTG GCGGGCGCCT 000560 000561 GTAGTCCCAG CTACTCAGGA GGCTGAGGCA GGAGAATGGC ATGAACCCGG GAGGTGGAGC TTGCAGTGAG CTGAGATTGC 000640 000641 GCCACTGCCC TCCAGCCTGG ACAACAGAGT GAGGCTCCGT CTTAAAGGAA AAAAATTTCT GGAATGATGT CCAATAAATC 000720 000721 AGAGAGAGGG ACTAGAAGAC TAATGAGGAC AGAAGCTTTT ATTCTTAACA CCTATATTTT GCTACCATTT ATATTGTCAT 000800 000801 CATATGCATA TAACATTTTA ACATTTAAAA ACTAGTTTAA ACAGAAATGG TTGCCCTGGA ATGTGGCCTG TGTTCTTTCA 000880 000881 AGGGAGGCCA GCAGTTTCTA CAGTGGCTGA GATGGTACCT TCATCTCACA CACCTACGCA GGCGTGCATT TGTGCTTTGA 000960 000961 TGTGGTTGTC CCTTGAAGAA GGAAGCAGTT CTCTTTTTCT TTTTTCCCTT TTCCATTATA GGATCAGTCA CTTCTTGGGG 001040 001041 CATTAGTAGT CTCATTTCCA GTGGCATCTT CCCTTGGCAA AAGGAATCCC AGATAGGACC TCATCTTTCT AAACAAATGC 001120 001121 TGTTTTGGGT CCTAACCATC CCATGTTTGC TTTGAATATG TTTAAGTTGC CTGGAATTAT CAACAAAAGA ATTAAATTTA 001200 001201 TTGTAGGTCA GGGCATCTTT TGACTCATTG TATAAAACAT TCACTTTAAA TGTATACCGA AATGTCCTTT AGGCTGGGAT 001280 001281 TACAGGCATG AGCCATGACA CCCGGCCTGT AATTTTCTTT AAAGACTGCC ACTGGGTGGA ACCCACTGGG CCCAGTGAGA 001360 001361 ACTACGGAAA AGAGACCCAT TCTTGCCCTC ATTGTTAGTG TCCACATCCG GATTTACCTA AACCCCACCC AGGTGGCATT 001440 001441 TGCATAGTAA TGAAAAACCG GTATTTTCTA GCTGTGAATC ACACTTCAAA TCCTGAGCGG CTGACTGTCA GGGGTGCGTC 001520 001521 AGGCCTGCTT GCTGGGAGAA TGGACGAGCT GGTTGTGGAG CGGGCGGGTC CCGCCACCCG TGGGCTCAGC ACTGGACTGC 001600 001601 TCCCAGAACA TTAAAGGTCT GGCTGATGTT CCATGCCACA TCTGGACATG AAGACCCATG TCTGCCCTTC TGTAGAAGGG 001680 001681 CCAAAGAAGA AAGGAGGCAT CACATGTTTC TGCTGTGGGG GGCCCTTCCG AGCAGCAGAC AGGAGCAAGG TACAGGAGTG 001760 001761 GCCTGATTCT GGGGTTTCCC TGCCCCCCCT GGGGTCCCTA AACTGCTGTG TGATATGTTT CTAACTATCT GGACAGCTCA 001840 001841 CCCAAGAGTC AGTTGTTCCC AGTCGCTTCT TGCTGAGGAT AAGCCAAAAG AGGGCCGGGG GCCAATCTGG TTTCTTTCAA 001920 001921 GTGAAATTAT GCTTCTCAAG CAGAGAATGA TTGCCCACAG CAGTTAAACC TTGTTTAATG GTAATTAAAT TGCTTTTCTT 002000 002001 CACTTTGAAA AATCTCTTAA TTTTCTGTAC AAAGGCAGGA AGCATTTTTC TTTGATTCTA CAGGATGTTT CTAAGTATGG 002080 002081 TGTAATCA