NONHSAT035954

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AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4gene cluster in cis and trans.

Annotated Information

Transcriptomic Nomenclature

DHRS4-AS1:DHRS4 antisense RNA 1 (HGNC nomenclature)


Function

AS1DHRS4 Regulates DHRS4 Gene Cluster Transcription.[1]

AS1DHRS4 Interacts with H3K9 and H3K27 Methyltransferases to Maintain Epigenetic Silencing of the DHRS4L2 and DHRS4L1 Genes.[1]

AS1DHRS4 has both specific cis and trans activity on inducing different repressive enzyme complexes in the individual promoters within the DHRS4 gene cluster locus.[1]


Expression

AS1DHRS4 is a cis-antisense transcript to the DHRS4 gene. [1]

Knockdown of AS1DHRS4 had no effect on DHRS2gene expression at the transcriptional level Knockdown of AS1DHRS4 increased both mature mRNAs and pre-mRNAs of the DHRS4 gene cluster[1]

siRNA Name Sequences
siASDhrs4-1 sense:AACUCAUUUGGUAAAAUGGTT[1]
antisense:CCAUUUUACCAAAUGAGUUTT[1]
siASDhrs4-2 sense:UGUUUCUGGAUGAAGACUCTTT[1]
antisense:GAGUCUUCAUCCAGAAACATT[1]

Labs working on this lncRNA

Department of Cell Biology, Shantou University Medical College, Shantou 515041, China

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Li Q, Su Z, Xu X, Liu G, Song X, Wang R, et al. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans[J]. Proceedings of the National Academy of Sciences of the United States of America. 2012,109(35):14110-5

Basic Information

Transcript ID

NONHSAT035954

Source

NONCODE4.0

Same with

DHRS4-AS1,C14orf167, "chromosome 14 open reading frame 167", "DHRS4 antisense RNA 1 (non-protein coding)"

Classification

antisense

Length

3038 nt

Genomic location

chr14-:24407940..24423392

Exon number

2

Exons

24407940..24410367,24422783..24423392

Genome context

Sequence
000001 AGAACACTGG GGAGACTAGA TCGATAGGGC TGCACAGAGG TGGCACAGTT GTGCCAGAGG TAGCAGGGAC AGGAGGGCTG 000080
000081 GCAAGGGAGG GTCCAGGGCT AGGGGATTCG GAGTGGCTTC AGGCGGACCA CGTGGCTACC TTTTTTCCAG GGCCAGACTT 000160
000161 TGGCAGCGTG TAAGGTCTGA GGACAGGGGC ACCGGAGGCC GAGGATGAGA GGCCAGTGCC TGTTTCCAGG CAGCCAGGGC 000240
000241 CTCAGAAACT CCGGCCGGAG CACTCACCCG TCGGTGGAGG CCGTTACCAG GGCCACCTTA TTTGCGAGCG GGTCCCGGCG 000320
000321 GGTCATCCCG GAGCTGGCCA TCCGCACCGA ATTCCAAGCC CGGGCACAGA GGCCTAGCAG CCCCGCCTTG TGCATGGATC 000400
000401 AGACCAGCAA GTATGGGTTC CACTCTTCCC AGGGGCGGTG ACAGAGTAGG GCGAGGGGCA GGACGAAGGG CGGGCCGATT 000480
000481 CCCTGCCCGC CCTGCTCCCC GCCCCGGTAC CGCTGTGAGC GGTCTGTGGC CCTGGGCACC TCCATCCGCC GCGGCGCCCC 000560
000561 TCCACCATCT ACCTTCCGCC TGACTGGGGC TTGCCTTTCC GGGCTGGCGG GTGCCACTTC GGATAAACCC TTTGGACTCC 000640
000641 TAACTCCAAT CAGGTGTCTG CTTTGTTGAG GACTCACAGA CACAGTCTCC TTTCTTCAAG ATCTTTACAA TGCAAGACCT 000720
000721 CACTAACACA CAGGGATGGT CTCCCAGAGG GTCTGTGCTG TTCCTTCACT CAGAACATCA AGATGCACTG AAGTAAGGAT 000800
000801 CCTCTATTCT ACAGTTCCTG CTAGCTGAGC TATTCCATGG GGGCTTCAGC AGGAAATTCC AAGGTTGGCT TTGACAAGCT 000880
000881 AAGGCCGGCT GGTGGAGCAC ATCGAGTTCT GGAGGTTCAT GTGTGTTTTC ATGAAGATCT GTCTGCCCGT AGCAGATAAA 000960
000961 GAGTTGTTGC CCCACTCCTC CTGGGGTCTT CTATTTTCCT GGGAGGAATT TCTGGATTAA CTGAACACAC ACACACACAC 001040
001041 ACACACCCTT TTGAAGCATC AACAGTAATT CTGAGTTCTT AGGGACAATG CAGATTAAAT CCACAATAAG AAAGACAACT 001120
001121 ATGGCCAGGT GTGGTGGCTC ACGCCTGTAA TCCCAGAACT TTGGGAGGCT GAGGCGGATG GATCACCTGA GGTCAGGAGT 001200
001201 TAGAGACCAA CCTGACCAAC ATGGAGAAAC CCCGTTTCTA CTAAAAATGC AAAATTAGCC GGGCATGGTG GCAGGCGCCT 001280
001281 GTAATCCCAA ATACTCGGGA GGCTGAGGCA GGAGAATCAC TTAAACCCGG GAGGCAGAGG TTGCAGTGAG CCAAGATCGC 001360
001361 GCCATTGCAC TCCAGCCTGG GCAAGAAGAG CAAAACTCCA TCTCAAAAAA AAAAAAAGAG TACTATTGAT CCAGAGGTGA 001440
001441 CCAGACTAGC CTCACTGGAG ATAATAGGTG ACATTATTAT GCAAAGTGGT TTCAGTTCCC TTGTCTTGTT TTTGGAATAG 001520
001521 TATAAGAGGC CTACAATACG AATAAATAAG GCCCATCACA AGCCTCACCA AAGGACAAAA CTAATCCACT TCTGAAGAAG 001600
001601 GCTCTTTGTT GGGCCAGATC AAATCCTTGG ACAGAACTGT ACTCTTAATC TCTGTAGTGA AAGTGGGGGG TAGTTTAAGA 001680
001681 ATTTATTAAC CTTCTACCTT GAGCAATCCC TCAGAAGTAA GAGGTGTCAG GCCTCTGAGC CGAAGCTCAG CCATTGTAAC 001760
001761 CCCTGTGACC TGCACATATA TGTCCAGATG GCCTGCAGGA GCCAAGAAGT CTGGGGCAGC TGAAAAACCA CACAAGAAGT 001840
001841 AAAACAGCCA GTTCCTGCCT TAACTGATTA ACCAACATTA CAACATTCCA CCATTGTGAC CTGTCCCTGT CCTACCTTAA 001920
001921 CTGATCAATC GACCTTGTGA CAGTCTTCTT CTGGACAATG GGTCTTATCA TCTCCCCACC ATGTACCTTG TGACCCCCTC 002000
002001 CTCTGCTAAC AATAGATAAC CACTTTTTAC TGTAATTTTC CATTACCTAC CCAACTCCTA TAAAGCAACC CCTTCCCCAT 002080
002081 CTCCCTTCAC TGACTCTGTT TTCAGA