ENST00000556013.2

PTCSC3,shorted for papillary thyroid carcinoma susceptibility candidate 3,is involved in Papillary thyroid carcinoma.

Annotated Information

Transcriptomic Nomeclature

PTCSC3:papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)(HGNC nomenclature)

Characteristics

PTCSC3,a 1152 bp thyroid-specific lincRNA gene (PTCSC3), located in a linkage disequilibrium block with a GWAS-derived SNP (rs944289).

Function

PTCSC3 expression is highly thyroid specific suggests that it is involved in thyroid function.

PTCSC3 expression is significantly down-regulated in tumor compared with unaffected thyroid tissue, and the risk allele is associated with significantly stronger suppression of PTCSC3. The restoration of PTCSC3 expression in PTC cell line affects genes involved in thyroid tumorigenesis and inhibits cell growth.

rs944289 predisposes to PTC by dysregulating the expression of PTCSC3, which acts as a tumor suppressor(1) </references>

Basic Information

Transcript ID	ENST00000556013.2
Source	Gencode19
Same with	PTCSC3,
Classification	intergenic
Length	571 nt
Genomic location	chr14-:36605314..36645674
Exon number	4
Exons	36605314..36605562,36623010..36623100,36631830..36631889,36645504..36645674
Genome context
Sequence	000001 GAAAGAGGAA AAAAGTGATC TGGGACCTGT TGTTTTTCTT GCATCCCATT TCTACTCTGC CTGTGAGTGA AGACTGTTGT 000080 000081 GGAAAAGTCA ACTGGAGAGA CCAGGTCAAA GGCCAAGCAG AAGAGGAATT AGGCTTAAGA CTGCACTGAG AGGGAACACT 000160 000161 AGACCATGGT GGCAAAATGG CCGAATAGGA GCAGCTCCAG TCTACAGCTC CCAGGGAGAT TAATGCAAAA GATGGAGTCT 000240 000241 CGACACGTTG CCCAAGCTGT TCTCAAACTC CAGGGCTTGA ACAATCTTCC CACCTTGGCC TCCCAAGGCA CTGGAATTAC 000320 000321 AGAGACAGTG CTCTGCAGGG AGTCTACCAC TGTGATGGTT AATACTGAGT GTCAACTTGA TTGGATTGAA GGATGCAAAG 000400 000401 TATTGTTCCT GGGTGTGTCT GTGAGGGTGT TGCCAAAGGA GATTAACATT TGAGTCAGTG GGCTGGGAAA GGTAGACCCA 000480 000481 GCCGTAATCT AGGTGGGCAC CATCTAATCA GCTGCCAGCA CAGCTAGAAG ATAAAGTAGG CAGAAAAACA TGAAAACATT 000560 000561 AGACTGGCCT A

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