NONHSAT087716

LINC00312, long intergenic non-protein coding RNA 312, could represent a potential biomarker for metastasis, progression and prognosis in nasopharyngeal carcinoma.

Annotated Information

Name

LINC00312: long intergenic non-protein coding RNA 312(HGNC nomenclature)

ERR-10, ERR10, "estrogen receptor repressor 10", "LMCD1 downstream neighbor", LMCD1DN, NAG-7, NAG7, "nasopharyngeal carcinoma candidate 7" ^[1]

Characteristics

LINC00312 is a long intergenic non-coding RNA (lincRNA) located on 3p25.3^[1].

Function

LINC00312 expression patterns can distinguish the non-cancerous group from the NPC group^[1]

LINC00312 could predict a good prognosis of no lymph node metastasis and a poor prognosis of lymph node metastasis in NPC patients, which indicated that LINC00312 could represent a potential biomarker for metastasis, progression and prognosis in NPC^[1].

Regulation

LINC00312 was strongly negatively correlated with EBER-1 in NPC, which suggests that EBER-1 could possibly regulate the expression of LINC00312 through some genes and signaling pathways^[1].

Expression

LINC00312 was significantly down-regulated in NPC tissues compared with non-cancerous nasopharyngeal epithelium tissues. Overexpression of LINC00312 inhibits proliferation by arresting cell cycle progression from G1 to S phase and increases the adhesion, motility and invasion of cells, both in vitro and in vivo via the H-ras/p–c-Raf and JNK2/AP-1/MMP1 pathways in NPC HNE1 cells^[1].

Diseases

nasopharyngeal carcinoma^[1]

Labs working on this lncRNA

Department of Medical Laboratory Science, Xiangya School of Medicine, Central South University, Changsha, 410013, China.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma[J]. Journal of molecular histology. 2013,44(5):545-54.

Basic Information

Transcript ID	NONHSAT087716
Source	NONCODE4.0
Same with	{{{same}}}
Classification	intergenic
Length	2887 nt
Genomic location	chr3+:8613468..8616354
Exon number	1
Exons	8613468..8616354
Genome context
Sequence	000001 TTTTCTTTTG ATAGAATGTC AAACTTACGA AAAAAGTTAC AAGAAGAGAA CAAAgagcta ttagagggtg ttgctgacac 000080 000081 aatgctttat cactcttgaa tattttcgtg tgtaattcct acaaataagg acattctccc acatagccac aatacaacca 000160 000161 tcaaaatcag gaagttaacg ctgatgtgtt tctaccatgt aatcctcaga tccaattcaa gtgtcaccag ctgtcccaat 000240 000241 aatgtctttt ataacaaaaa cattcagtct aagatcactc attctattta gttatcttgt ctattcttca atttggaagt 000320 000321 gttctttgtt ctttcctgaa tgttcatgac cttgacatct tagaagatta aaggttattt aaagttgttg agttaaatat 000400 000401 ccattaaatt aggtttgtca gatatttcct cgaaattaga ttcagcttat gcattttttg gaaggaatac cacagaagtg 000480 000481 atgttgtttt ctttctgttg catccaatca gatgatacag gattttgatt tgttccatta ctgttgacat gaattttgaa 000560 000561 catttgataa tgccagtatc agccagattt ttccattgta aagtcattcc tttgtccttt gtatttaata agtatgttta 000640 000641 gggactttga gactatgtca atgtcctgtt cttcatcaaa attccactca ctcattctta gtattcattg acgtttactg 000720 000721 atcgaactaa ttattattat gatagttgcc aaatgttggt ttttctaatt caatcatttc tttagtgttt attagcattc 000800 000801 tactataagg aaaagcacta tcttctcccc atttattaat tcacatattt acatcagctt ggagttattg atttctattt 000880 000881 tattaaatag tttataattg attaccatcc ttatttattt taatgctcaa attgtcccaa attatggcca aagaaagctc 000960 000961 cttcaaactg gttgctatgt ccttttgaca tggcccatca ttctttaaac acattttaca tctggcacaa taacgtgcta 001040 001041 catacccatc ttgtattttt cctgccccat ctttgaaatc agccattctc aaggggttcc ttcttaatCT GGCTGTTGTT 001120 001121 GTGTTGGAAC TCCTGGTACC ATCTTAGAAC CTTAAGGAGA CAAGCGAACC AAGCCAATAA GCTTTCCATG ATGCTGCTTA 001200 001201 GAGTTAAACA GAGCCCAGGT ACTAAGTTAT GTCATGGAGA CAGTGAACTA ACCTCTGGAC TGCTTGCTAC ATGAGACAAT 001280 001281 TGATTTTCTT ATTTTCTATG TAGGGTGGTA CATTTCCTCA TTTTGAGATA TTTCTTCAAC ATATAGCTTT TCATTAGTGG 001360 001361 GGATTTTGTC AATTATAACC AAAAACAATG TGACGGATAC CCAAGATGTT TCATGTTGTA GCTTGGGTGA ATTACACATT 001440 001441 TCTGAAGCCA TTACACTTCC TAGTTTATTT GGAtttaagt tgacaaataa aaattgcata tgtttatggt ctataacatg 001520 001521 gtgtttcgat atatgtatac atcgtggaat ggctaaatca agctaacata tccattacct cacatagtta ttttttgtgg 001600 001601 tgagaacatt ttaaaaatat tgtcttagca attttcaaTC AAGCCTGTCC CATGGAGACA CAAGCAATAG TGACATGAGC 001680 001681 ACTTGACTCG CTGGGTTATC AGGCTTTGGC TCCAAATGTT TGGCTTCAAA TATGAAAAAG TTACATGAAA GATGAAACTA 001760 001761 TGCAATGGCA TGGCTGTTGG TCATTCACAT CTCTCTCTGC CAAGAATGGG GATGACGCTG TTGAAGGAAG AAATGTGTTT 001840 001841 TCTCCTTTTT CTCAAGTGAT ATTTGCCTTA GGTCAGATTC TACTAGTTTA AAGCAAAACG ATCTCCTGGT CTGATTCCTT 001920 001921 TGGGTCTCTA ATAATGGAAA CTGCAAGGAT CAGCATAAAG TGTTCCTTTG TTCTGACGTT GGTATAACAT TGCTTCTTGA 002000 002001 AAAATGAAAG TATTTGGACA TACAGACAGA AGCAAtatta ttcaggtctt ccttgttgca agtgagggaa atccaattaa 002080 002081 aactggttta aacctaaaaa aaaaaaA

[ref1-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma[J]. Journal of molecular histology. 2013,44(5):545-54.

[1]