ENST00000414769.1

MIR503HG, a lncRNA which is likely originated at least 370 Myr ago in the tetrapod ancestor, may functions like H19 by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner.

Annotated Information

Name

MIR503HG: MIR503 host gene(HGNC nomenclature)

"H19 X-linked co-expressed lncRNA", H19X, MGC16121

Characteristics

Expression pattern for an X-linked H19 co-expressed lncRNA (H19X, identified as ENSG00000223749 in the Ensembl database), in five tetrapod species.

MIG503HG could potentially promote the transcription of between 2 and 7 miRNAs in different species, such as Human,mouse,Opossum,platyous,xenopus,. This lncRNA (that we name H19X, for H19 X-linked co-expressed lncRNA) is ikely originated at least 370 Myr ago, in the tetrapod ancestor.

Fuction

H19X is a neighbour of Rsx, the lncRNA that drives imprinted X-inactivation in marsupials, suggesting that H19X may itself be imprinted. These results suggest that H19X may function like H19, by promoting miRNA transcription, preferentially in the placenta and in an imprinted manner.

Expression

Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians.

Evolution

Expression pattern appears to have dramatically shifted during evolution, from an ancestral testes-predominant pattern to preferential expression in the chorioallantoic placenta of eutherians.

Labs working on this lncRNA

• Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland.

Basic Information

Transcript ID	ENST00000414769.1
Source	Gencode19
Same with	lnc-PLAC1-1:2, MIG403HG, H19X, MGC16121
Classification	intergenic
Length	720 nt
Genomic location	chrX-:133677473..133680660
Exon number	3
Exons	133677473..133678029,133678744..133678827,133680582..133680660
Genome context
Sequence	000001 GAAGGTAGAA GGTGGGGTCT GCCGGACGCG TGTTCCTGCC ACCAGGTGCC CGCTCCCCGC GAGGCCGGCT CAGGAGCAGA 000080 000081 AGGAAGCCCG GTGCCAGCCA GCCTTCCTGA AAGACCAAGC CCGCGCCATC CGGCTTCCTC CAGTGGACGC CTGCAGGACC 000160 000161 CAGGAATGTT TTTCTTGAAG GCATCCAGCA TCTCCAGTTA GCAGTACTGA TTTTTTTTCC CCCCAACAAA GGAACACTAC 000240 000241 ATCAACACTG TTGGCGGGGA CCTGGACACA GAAGACTCCT GTTTCAAGAA AATACAATCA TCTCTCAAAG GCTGTAATTT 000320 000321 ATATGCATTT TAAAACTCTA GGCATTGAAA ACCACCCAAG TGTCCCAAAT AGAAGGGTAA TATATAATCA ATCACTCAGT 000400 000401 GTAATATTAT ACATCCTTTA AAAATGTTAT TGGGAAATGT TTTATGATCT GTAAGTCCAA GGAATCCTCT CCCACCATTT 000480 000481 CTTTCCCCCC GCTGTTCCCC CATACCCACA CTTCTTTGTT CCAATTGGCA TGTAAATTTG GTTTTCCCGC CAAATGAGTC 000560 000561 AGTCATGATG GGAACCTCAA CTGATTTGAA CAGATGTGTG TCAATGTTAC TTGGAAAACT AGATGTCAAT AACCAGGGTC 000640 000641 ACAGAAAAAG GCAGTGGTCA CAACTCTGTA AAAATGTATG CATGCACACA GACAAGAACT AAAGTGGAAC CCCACACAGG 000720

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