NONHSAT040920
PWRN1, Prader-Willi region non-protein coding RNA 1 of 1451 bp, which was located between NDN and C15orf2, may play a role in PWS (Prader–Willi/Angelman syndrome) with C15orf2.
Contents
Annotated Information
Name
PWRN1:Prader-Willi region non-protein coding RNA 1(HGNC nomenclature)
NCRNA00198, "non-protein coding RNA 198"[1]
Characteristics
PWRN1,a 1451 bp Prader-Willi region non-protein coding RNA 1,located between NDN and C15orf2 in 15q11.2[1].
Function
PWRN1 may functions with C15orf2 in PWS (Prader–Willi/Angelman syndrome)[1].
Expression
The expression of PWRN1 is most abundant in testis, but also present at low levels in several other tissues, including fetal brain[1].
RT-PCR primer pairs used for PWRN1 were as follows,
| Primer | Sequences |
|---|---|
| PWRN2-AK058147-F2 | 5'-AACACGGAGATGCATTGACA-3'[1] |
| Ex26R | 5'-ACCTGGGCAACAATTGACTC-3'[1] |
| PWRN1-Exon19-F | 5'-GCAACATTCGAAACCCAGGTGCT-3'[1] |
| Ex26R | 5'-ACCTGGGCAACAATTGACTC-3'[1] |
| AK058147-F2 | 5'-AACACGGAGATGCATTGACA-3'[1] |
| AL704599-R2 | 5'-TCTGTTTCCCAAGCTGGAGT-3'[1] |
| PWRN1-Exon2-F | 5'-GATTCCCCAGCTGATCCTCG-3'[1] |
| PWRN1-Exon8-R | 5'-AGAAGGGTGTCAATGCATCACCG-3'[1] |
| Ex23F | 5'-GCCTCCTTTATTGAGAAATGTTTT-3'[1] |
| Ex26R | 5'-ACCTGGGCAACAATTGACTC-3'[1] |
Allelic Information and Variation
PWRN1 is biallelically expressed in testis and kidney, but monoallelically in fetal brain[1].
Labs working on this lncRNA
- Institut für Humangenetik, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany.[1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Buiting K, Nazlican H, Galetzka D, Wawrzik M, Gross S, Horsthemke B. C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain[J]. Genomics. 2007,89(5):588-95.
Basic Information
| Transcript ID |
NONHSAT040920 |
| Source |
NONCODE4.0 |
| Same with |
PWRN1, NCRNA00198 |
| Classification |
intergenic |
| Length |
1451 nt |
| Genomic location |
chr15+:24803299..24832926 |
| Exon number |
9 |
| Exons |
24803299..24803468,24811803..24811947,24813044..24813329,24814930..24814956,24815179..24815275,24819657..24819960,24820054..24820150,24825374..24825477,24832714..24832926 |
| Genome context |
|
| Sequence |
000001 AGAACAGGCA GAGGCAGTTC AGGGGTATTC TGGTTGCCTT ACCCAGCTCT GAAGTCTGTC AGCCTCTTCA GATGTCACTT 000080
000081 GCCATGTGGT AAGGAAGTGT AGTCAGCAGC TGGTGCAGTG GGAAGAAGAG AAAGGAAGTT CCCCAAGACA AAAACATCTC 000160 000161 GGCAGACCGT GATCATGGGC TACATTCTCC GTACCAGCTT CATAGCTCCA GTGAGAAAAT AAATTCCTGC ATCCAGGAGA 000240 000241 TGTGGAGTAA GAGATACAGC TGCCCTTGAC CATATTTCTT ACTTCCGAGA AGATCGTAGC AGTAATTCAG TCTTCAGGGA 000320 000321 ACACCAAGGC CTGTTTGATT TTCCAAGTAT CAACAAGTGG AGTTGACAAG AGTGACAAGT GGTCAGAGCA AAGCATTTCA 000400 000401 TGATGACTGT AACGTGCCTG TGTCAGCAGC GACTGCTTAC AGTGAGATTC ACATGACCAT CGTTTATGAC ATAGGAAGAA 000480 000481 TAAAAGGAGA GAGAGAGAGA AAGATAGGTA GTTGATCAAA ATGAAGAATT GGATTTGGAA AGCAACTTCG AATAGTCTCT 000560 000561 GCTTATATTT CTGAGATTAA GGCAAACAGT CTCAAGAATC TCATCCAGGA TACCTCATCA CAGGCTGGAG TGCAGTGTCA 000640 000641 TGAGCTTGGC TCACTACAGC CTCCATCTTC TGTGCTTAAG GATCCTTCCC TCTCAACCTC CAAGGTAGCT GAGACTACAG 000720 000721 GCAACATTCG AAACCCAGGT GCCACTCCTT CAGGAAGGTA CCATCAAGCT CCAAGGACTC ATCCTCTTTC TCCTTCCCCA 000800 000801 CTACCTAGTC ATTAGAGCGT CAGCATCCAC TTCCTGAAAG GAAGATGCCT GTTTTTCACA TATCCCAGAA AGCCTCATTT 000880 000881 TAGGACAGCA TTTAGCAGAG TGTATTCAGG ATCCCACTAA CCTTTTCGGA AGACATGACT TCCAGATGAT ATAAGGCAAG 000960 000961 AATAAGAAAT TTCAGTGACA GGGAACAGAA ATCATATTTC TGCATTCAGG ATCATGTTTT CTTGGCTCCA TCAGGAACTG 001040 001041 TGCAGGACTG TGCACTCTGT TGATACTCAC ATGGTGGAAT TATATTGCCC TTGGCCAACC CTAAAGCCAT CAAGATAGCA 001120 001121 GCAACTACTC TATCATTACT GTACCACCAC CTGTATGGAT CTCGTTGCCC ATATGAAACT GAGTAAGGAA CAATGTGCAT 001200 001201 CACACTCACA GAGAAAGATG GACAAGTTTG GAATAATTCA CTGTCGAAGT CTTCTTGAGC TGAGCAGTCA TGTGAGCTTG 001280 001281 GAAGATGATC CCTCTCCAGC TGATCCTTCA GCTCAGGCCA TCATCTACAT CTGGATTCCT GACCCGGAGA AACTATGAGT 001360 001361 AATGTGTGCT GCTTTTGAGC CACTAAGCTA CATGGTAATA GGCTATGCTT CAATAAACAA TAATACACTT GATGATAAAA 001440 001441 AAAAAAAAAA A |
