MIAT

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Name

MIAT: myocardial infarction associated transcript ((Ishii 2006)).

Characteristics

MIAT, was specifically up-regulated both in the plasma fraction of whole blood and aqueous humor of cataract patients [1].

Cellular Localization

In epithelial cell.[1].

Function

Figure 1.LncRNA‐MIAT is shown as a cataract‐specific biomarker. [1].

MIAT knockdown could affect the proliferation,apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress [1].

MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function [1].

Regulation

MTT assay revealed that MIAT knockdown significantly decreased the HLEC viability.[1].

Diseases

  • Neuroendocrine prostate cancer (NEPC)

Expression

LncRNA-MIAT was significantly up-regulated in cataractous lenses [1].

Labs working on this lncRNA

  • Eye Hospital, Nanjing Medical University, Nanjing, China.
  • The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Cite error: Invalid <ref> tag; no text was provided for refs named ref1