Lnc-EIF3M-1:1

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Annotated Information

Name

WT1-AS: WT1 (Wilms' tumor 1) antisense transcript.

Characteristics

0.4 - 3kb, spliced and present in multiple splicing isoforms (Dallosso (2007)), as well as a protein coding isoform (WIT1) transcribed from a downstream promoter (Eccles (1994),Campbell (1994)). Transcribed antisense to WT1 from intron 1 or from the same promoter region (bidirectional) of WT1, corresponding to a differentially methylated regulatory region (Eccles (1994),Malik (1995),Malik (2000)).

Function

WT1-AS transcripts are exported to the cytoplasm and form heteroduplexes with WT1 mRNA, with a proposed regulatory role in WT1 expression via RNA:RNA interactions (Dallosso (2007)).

Disease

gastric cancer, hepatocellular carcinoma

Expression

Imprinted in humans (but not in mouse), with monoallelic (paternal) expression in normal kidney (Malik (2000),Dallosso (2004),Dallosso (2007)). Co-regulation with WT1 during mouse kidney development, and co-expression in mouse and human tissues, including fetal spleen, fetal kidney, and normal kidney (Dallosso (2007)). Abnormal splicing of WT1-AS has been reported in acute myeloid leukaemia (AML) samples (Dallosso (2007)).

Conservation

WT1 has a positionally conserved antisense/bidirectional transcripts in mouse and humans, although WT1-AS RNAs do not show extensive sequence conservation between these species, except at their 5' ends, which may extend into WT1 exon 1 (Dallosso (2007)).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	lnc-EIF3M-1:1
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	2354 nt
Genomic location	chr11+:32457284..32461620
Exon number	,
Exons	,
Genome context
Sequence	000001 AACCCAACAC GCGCTCTCAG CTGGCCGGTG TGGCACAACC CTCCCCCCAC CTCCCCTTCT TGGCCTTCGC CAGTGTGGGA 000080 000081 GCCTCGTCTC ACTGGAGAGT CCGTTCAGAA TCCTTGTGGG GGCGGGGAGG GGAAGAGCAC CGGTGCGAAC CCCGGGGTGC 000160 000161 CCCCTCGCCC GACTTGGACT TCTCCGACTA AAGAGGTGGG AGGAGTTCCC TGCAGCCTGC GGGGCCAAGA AGAAAGTGCT 000240 000241 AAGCTGAGGA GCCGCAGTCG GAGGACCCCA GGGACCCGAC AGGAAGTCTC CGTACGACCC CAACGGATCC ACATGCCCGG 000320 000321 AAGCCCAGGC GACACTAAGC CAGCGCTGGG GAACTGACGT ACTCCTGCAG TCGCAGGGCG CTCCATGCCT CTCTGTCCTC 000400 000401 TTCTTTGTTG TGGGTAACGT TCTCTGCGGG AGACCTGAGG TTTTCCAAGG GGGACATGCC AGCTACACTG GCCTTGGCGC 000480 000481 CCTGAGCTAA GCACCAGGAC TCACAGCCTA GCACGAAGGC AGGTAGCACC TTCACCCGCC GCGGACGATA GGCGCTCTCC 000560 000561 TGTACCTCCT TTAGCTCGCG AGGCCCGCCC TTCGCGAGGT CCCAGAGAAA AGCAGGCTGT GGAAAACTGG GCGCCCCCTT 000640 000641 CTTTCACCCA CCTTCTTACC CCTGTCAGCG CCGAGATCTG TAGCAGAGGT TCCTGGTCTG AACCACCGAT TGGCAAAGAA 000720 000721 AGCTGCAGAT TAAACTTCTC GTTTTACAGA GAAGGAAACT GAGGCCCAGA CAGCCGAAGG AGAGGCAGTC TATGGAGCGC 000800 000801 AGCGGTAAAG AGCAAGGGGT TGGTGGCCCC AGAATGGAAC CTCAGCTCTG CCAGGTAACC AACAGCTGTG TGACCCTAGA 000880 000881 CGAGTTCCGC AGTCTCTCTG AGCCTCAGTT TCCTTACTGG TCAAACGGGA TAATGGGATA CTAGCGCCCA CCTCATAGAG 000960 000961 TTGTTCTGAG GATTAGATAG GAGAGCAGTG TGGGCCTTTG ACTCAATCAA CTTTACAGTT TTTGTTACTA CTACTGTTTA 001040 001041 AGGACAGGAA ACAAGTTAGT GGCAACGCCG AGCTGAAACC CGGGTCTCTC AACGTCCAGT TGGAGGTTTT ACCCACCACC 001120 001121 CCTCTACCTC TTCAGAGCTA ATGGGATGCA GAGGCGAGGA CAGCCCCTGG AAAACCATGT GGCGTTGATA CACTGGCAAA 001200 001201 GCGCAGGCAT CCCGGCCTCG AAGGTGCATA ATTATTGCAA TATGAAAAAA TCGAGGCTGG GTAGGAGCAG GGCAGTGAGG 001280 001281 ATTTCTCAAC CCTTACTTTC ACCCCGGCGC TGTCCACTGC ATCTGACAGA GCGCGGAGCT GGGCTGCTAC AGCCGCAACC 001360 001361 CCAGGGACCA GTGCGCACGC CTGGGCCGCC CTCCGGGAGT CACCCAGCGG CCGCGGACAA CTGAATAAAC ACCCCAAAGC 001440 001441 GCTGCGGTCG GTCAAGGGCG GGGACAGCCA CACTGCGCGC GGGGCCCGCA GGCCGTAATA AAGAGTGGCT CGACCTCGCT 001520 001521 GCTGCCTGTC GCGGGAGAGG AACAAGCTTT CGACTAGCGC CTCTCCCCGG GGCCCGCGCC CCGAGCCCCA CGCGCAAGAC 001600 001601 AGCCCAACAG CTGTTCCTCC CCTCCCCGCC GACTCCAACT CTTCGGAATC TGCCCACTCG GGGCTGCAGG GCAAGTGTTT 001680 001681 AGGATGGTTC CCAGCCCCGC GCTGGCGGTG AAAATTTCAA CGTCATTCCT TCAATTAAAA AAAGGGGGGG GCAAGGGAGG 001760 001761 GGCTTTGTGA TAACTACTCC CAGCTTCTTC TGATCATTTC AAAATTAAGT CGATTTTTTT TAACCAGTCC CCACTTACTG 001840 001841 TCCTAACTCT CCTCGCTGAC CCTATCTGGG AGCCCGGAAC CGTTAGGTAC TGCCGAATGC GGTGCAAAAT TTCCCCCTCT 001920 001921 CCCCCAGTTC GCAGTGCCTG GAGCCGCTGG GGTTACTCGT CTGTTCTGAT GCCACCGCGA GATGGTCCCC GAGCTCCCCG 002000 002001 AGAGTCCTCA GTGAAAGGAT TCCGCGGCAC TGCCTCTATT ATTATACCGT AAATCTTTTT AAATTCTGG