LINC00673

Annotated Information

Approved Symbol

LINC00673:long intergenic non-protein coding RNA 673

Synonyms

HI-LNC75^[1]

Chromosome

17q24.3

RefSeq ID

NR_036488

pubmed IDs

23040067

Characterastics

HI-LNC75 is human islet lncRNAs which was found to be highly cell-type specific, developmentally regulated, and tightly linked to the differentiation of ES cell-derived islet-cells. ^[1]

Disease

type 2 diabetes^[1]

Function

Knockdown of HI-LNC25 in β-cells causes downregulation of GLIS3^[1]

HI-LNC75 acts as a positive regulator of an islet mRNA GLIS3.^[1]

Expression

HI-LNC45 is significantly increased decreased in type 2 diabetes.^[1]

labs working on this lncRNA

Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomèdiques August Pi I Sunyer, 08036 Barcelona, Spain.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Moran I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, et al. Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes[J]. Cell metabolism. 2012,16(4):435-48.

Sequence

>gi|302318969|ref|NR_036488.1| Homo sapiens long intergenic non-protein coding RNA 673 (LINC00673), long non-coding RNA

000001  AGGGCGCGCA GGCGGCGCGG GTGCGCGGTG CGGCGCTGGT ATCCAGAGGA CGCGGTCACC GCCTCTGGCA TTTGTCGTTC  000080
000081  TGCGCTTCTC CGCAAGGACC CTCTGTTAGG CAGGCGCCCA CCGTAAGCCT CCCGGGCCTT GTGAACCTGC AAACCCAAGT  000160
000161  CTGAGAGACG ATCCGCCTTC AGCGCTTTCC AGCTTGGCAG AGAGGCTTTC CCGGCGGGGA TCTTTGGTTG GCGCTGGCGA  000240
000241  TGCGCGGGGA AGAAAGGCGA GGAGCGGCGT CCAGGCTGGG TGATGTCCCA GCACGAGTAG GCGGGATGCG CTCGCTTGGT  000320
000321  CCTCCGGGCG CCCGGTCCCT GCCCGCGTCG CGCGCCCACC CCTGGGGACG AGAAGGCGGC CGCCTGAGGA CCCCCGCCCG  000400
000401  CGACCTCCGC GAGTCTGGAG CGCAGAGGAC AGGGTCTGGC TGCTCTTTGG CCTTGGATGG AAAGTGGGGA ATTGGGTGGG  000480
000481  GGGCTGCGGA CCCCTTAACG TGGATTACTT GGTGTGTATC AGCTGGGCTC AGAAGACCCA CGACCTCTTC TCCATCCGTG  000560
000561  GATTGATTTG TTCTGCTTAA CAGCTGGGTC GCCAAGCTGG AGGTATTTTT CCCTCTCCAC CCTGGTCTTC TCCTGTAACG  000640
000641  TGTGGCCGCC TTTTCCAGCA CGGCCTCCTG CCTTCCTGGT GCACTTTTTG GAGAACGTGG TGGAATCAGA GGTTTCTGGC  000720
000721  TGACTCGGTG GGTGCTTTGA ACCAGGAAAG GACAAGAAAG AGGATGGGAA GGACTGATCC ACATTCCCAC CAGGAAGTTT  000800
000801  AGCAGAACCC CCGCGTGCCA CCTGGACCCC TTGGAAGGAC CTGGCTCAGG CTGGACCACC TCTTGAGAGG CAGGAGCTCT  000880
000881  GGATTTGATC AAGAATTCTT TGCTGAGCAT GGTGCCTCAT GCCTATAATC CCAACACTTT GGGAGGCCAG TGTGGGAGGA  000960
000961  TCTCTTGAGC CCAGGAGTTC AAGACTAGCC TGGGCAACAC AGAGAGACCC CATCTCTAAA ATAATAATAA TAATAAAATA  001040
001041  AAAAATTAGC AGGGCATGGT GGCATGTGCC TGTAGTCCCA GCTACCCAGG AGGCTGAGGC AAGAGGATGG CTGGAGCCTG  001120
001121  GGATGTTGAG GCTGCAATGA ACTGTGATTA CCCCACTGCA CTCCAGCCTG GGCAAAAGAG CGAGAGACCC TGTCTCAAAT  001200
001201  AATAATAATA ATAATAATCT TATTTTGGAG AATAAAGAGA CCTCTGGATT TGAGGTGCCA TTTGGGTAGA AAGAAAAGAC  001280
001281  GTTTACACCG AGAAATAGTC TGTGTTGCCC TGAAGGAGCA GAGGGATGCA TCGCTGGAGG TGACCTACAG TTGAAGAAGA  001360
001361  CTCATTATGA CAGACCTTGT CCTTCTTCCT TGTGGAAAGT GTTTCCTCTG CTGCTACTGC TCATGAGACT CTTCCCCCTC  001440
001441  CCTGTCCCAG GGAACCAAAG GGCTTTCTAC CACACCCTTT CTTGCCCCCC GCCTCCCATG TCTGCTGTGC CTTTGTACTC  001520
001521  AGCAATTCTT GTTTGCTCCA TTATCTTCCA GCCGGATACA GAGTGAATAG TTAACCACAC TTAGGTCAAA TAGGATCTAA  001600
001601  ATTTTTGTTC CTGCTCCGTG TAAAGAGGCC AGTGTTTGTG TGTTGCAAGC AGCCTTGGAA TAGTAACTCT TCTCATTTGT  001680
001681  TTGGGATCTG GCCACCAAGT TCCAGAATGA TACACGGATC AGTGCAGAAG TTCATCAGGC TCTCGGACCT TAGGGCTGTT  001760
001761  GGAGAAGGCT TCAGCAGCAG AACTGATGGT GAAGGCTCGT GTTCTCCATC CTCAACTTTC TTTGCTTCGA TCATACACAA  001840
001841  GAATACATTT GGAAGGGCAA AAAATGAACA CTGTCGTTCA TTGCAGCCGT GTTTTGTGAC ACAGATGCAC AGTCTGCTGT  001920
001921  GAAGACCTTC TCTCAAGTGG CATTTGGGAG TCCATGCCAG ATCATGGTGC TTCATGAGAG ACTGACAGCT ATCAGGGGTT  002000
002001  GTGGCACTTA GTGAGGACTC TCCTCCCCCA GTGTGTGCTG ATGACACATA CACACCTGAC AATAGCTTGA GTCTTCTCTG  002080
002081  TTCCTTTTAC TCTGTAGCCA ACATACACAT GATTTAAAAC CCTTTCTAAA TATCTATCAT GGTTCATCCT TGTCCAAATG  002160
002161  CAGAG

[ref1-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Moran I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, et al. Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes[J]. Cell metabolism. 2012,16(4):435-48.

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