HIF1A-AS1
Contents
Annotated Information
Approved Symbol
HIF1A-AS1
Approved Name
HIF1A antisense RNA 1
Synonyms
5'aHIF-1A
Chromosome
14q23.2
RefSeq ID
NR_047116
OMIM ID
614528
Ensembl ID
ENSG00000258777
pubmed IDs
21897117, 24875884
Expression
The expression of 95 apoptosis-related lncRNAs were examined in VSMCs with overexpression or silencing of BRG1. The changes in HIF1A-AS1 expression were the most significant.And expression levels of HIF1A-AS1 were up-regulated by 3.26-fold compared with control by BRG1 overexpression, and down-regulated to 0.37-fold by BRG1 silencing.[1]
Functions
The two antisense RNAs are activated in response to partially different kinds of stress, such as low oxygen tension and Top1-mediated transcriptional stress and DNA damage.[2] Suppression of the lncRNA HIF1A-AS1 by siRNA in VSMCs reduced cell apoptosis and promoted cell proliferation.[1]
Characteristics
Cell fractionation showed that 5'aHIF-1α and 3'aHIF-1α are recovered mainly in the nuclear fractions whereas HIF-1α mRNA was found in both nuclear and cytoplasmic fractions.[2] FISH images showed accumulation of both HIF-1α mRNA and antisense 5'aHIF-1α RNA at the perinuclear region of cells.[2]
Sequence
>gi|537361086|ref|NR_047116.1| Homo sapiens HIF1A antisense RNA 1 (HIF1A-AS1), long non-coding RNA
000081 CGCTGGCTCC CTCCACACGC GGAGAAGAGA AGGAAAGACT ACAGTTCAAC TGTCAATTGG TTGATCACCC GGATTTTATC 000160
000161 TACACCTTAG CCTATGGTTG TTCATCTCGT CTCTGCCTAT GGCCCATTGA CTCCCGGATC CCAGCTCCAT TCTTCGGTAC 000240
000241 TTTACGCACC CTGCTTCCAG TACCCCAACC AGAAGAATAT ATATAGCAGT TAACTGTCAG CTGGCGAAAA GGAGGAAAAT 000320
000321 TCAGGAAGAT AAAATAGCTG AATGAATTAT CCCCGCTCCA GAACGCAGAG GAAAAATGAA ATGGCCAGAC CCAGATGTTA 000400
000401 AAAATGTGTT CCTTGCTCTT TCCTGCCCTA GCAAGGGCTG TTCCATGTTT AGGGGATGAA TGCCGCTGAG AGTATTAGCA 000480
000481 AAAATACATG TGTCATTGAG TCTGAGGAAG ATAACTGAGA CATACAGGTA TTTCTCATAA TGCATGTGGG CATCCATAGA 000560
000561 CATATTCTTA AATGGCTTAA GGACTTGGAA ACTACCTCTA GGAAACCTGA AACTTGAATG TTGGTCCACT AGGGAGAAGA 000640
000641 AATGTTCCAT TA
Labs working on this lncRNA
- Department of Biochemistry “G. Moruzzi”; University of Bologna; Bologna, Italy [2].
- Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China .[1]
References
- ↑ 1.0 1.1 1.2 Shuwei Wang, Xiwu Zhang,Yang Yuan, Mengwei Tan, Le Zhang, Xiang Xue, Yan Yan,Lin Han and Zhiyun Xu."BRG1 expression is increased in thoracic aortic aneurysms and regulates proliferation and apoptosis of vascular smooth muscle cells through the long non-coding RNA HIF1A-AS1 in vitro." European Journal of Cardio-Thoracic Surgery 47 (2015) 439–446.
- ↑ 2.0 2.1 2.2 2.3 Bertozzi, D., R. Iurlaro, O. Sordet, J. Marinello, N. Zaffaroni, and G. Capranico. "Characterization of Novel Antisense Hif-1alpha Transcripts in Human Cancers." Cell Cycle 10, no. 18 (2011): 3189-97.
