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Welcome to LncRNAWiki 105,824 human long non-coding RNAs inside

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Featured LncRNAs Small Proteins Disease

Introduction LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community. Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia

Disease Top 10 Diseases 213 Neoplasms 39 Nervous System Diseases 33 Congenital, Hereditary, and Neonatal Diseases 21 Musculoskeletal Diseases 21 Hemic and Lymphatic Diseases 21 Mental Disorders 19 Cardiovascular Diseases 15 Nutritional and Metabolic Diseases 15 Endocrine System Diseases 10 Skin and Connective Tissue Diseases Top 10 Cancers 36 Breast Cancer 31 Prostate Cancer 30 Hepatocellular Carcinoma 28 Gastric Cancer 26 Lung Cancer 18 Colorectal Cancer 12 Esophageal Squamous Cell Carcinoma 12 Bladder Cancer 9 Glioma 9 Lung Adenocarcinoma Among these 948 featured lncRNAs, 404 have been experimentally proved to be associated with cancer and other diseases (Disease). Top diseases and top cancers, and the lncRNA numbers are listed.

Classification The majority of the lncRNA information was initially seeded with a subset of information from GENCODE, NONCODE, LNCipedia, and lncRNAdb, and we classified these lncRNAs into seven groups (Intergenic, Intronic (S),Intronic (AS),Overlapping (S),Overlapping (AS), Sense and Antisense) based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). Help

Featured lncRNA LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence. In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated (the detailed list is available at Featured LncRNAs).

Small protein We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki. As a result, we identified 9,387 lncRNAs potentially encoding small proteins and we further validated 2,246 such small proteins with high confidence by considering protein instability, secondary structure and transmembrane helix (lncRNAs and small proteins, Help).

How to Cite If you use any data or information in your work, please cite the following primary publication: Lina Ma, Ang Li, Dong Zou, Xingjian Xu, Lin Xia, Jun Yu, Vladimir B. Bajic and Zhang Zhang. LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs. (2015) Nucleic Acids Research, 43:D187-92. Related publication: BIG Data Center Members: The BIG Data Center: from deposition to integration to translation. Nucleic Acids Research 2017, accepted and in press. Lina Ma, Vladimir B. Bajic, Zhang Zhang. On the classification of long non-coding RNAs. (2013) RNA Biology, 10(6),924-933.

About Us Our group works in the field of Computational Biology and Bioinformatics (CBB), currently with a particular focus on building biological knowledge wikis in aid of community curation of massive biological knowledge.

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