LINC01826
Contents
Annotated Information
Name
LINC01826:long intergenic non-protein coding RNA 1826
lnc-MKI67IP-3[1]
Characteristics
Lnc-MKI67IP-3 is located on chromosome 2 and its function has not been described thus far.[1]
Cellular Localization
Lnc-MKI67IP-3 is primarily localized in the cytoplasm.[1]
Function
The present study shows a strong correlation between lnc-MKI67IP-3 and let-7e or IκBβ. The minimum free energy (MFE) between let-7e and the let-7e binding site in lnc-MKI67IP-3 is −17.8 kcal/mol. In addition, Lnc-MKI67IP-3 could inhibit the pro-inflammatory effects of let-7e as a ceRNA through binding to let-7e in the cytoplasm.[1]
Regulation
Let-7e mimic significantly down-regulate lnc-MKI67IP-3 expression, while let-7e inhibitor markedly up-regulate this expression and let-7e inhibitor could be considered as an inducer of lnc-MKI67IP-3, just like vitamin C.[1]
Diseases
Inflammatory response in vascular endothelial cells[1]
Expression
In human umbilical vein endothelial cells (HUVECs) treated with ox-LDL for different times, lnc-MKI67IP-3 is significantly down-regulated. [1]
Sequence
>XR_001739207.1 PREDICTED: Homo sapiens uncharacterized LOC107985818 (LOC107985818), ncRNA
000081 AGTTGATGAG AAGTGTCTGC TTCCATTGCC CGTGAATCCC TAACAGAATG GTGCCAGGCT CCACCAGGAG ACCTTCCTGA 000160
000161 GTCCCATCTG AAAGCCTCCA CCTGAATGCG TCCCTCATTT TAATGACCCA GCCAGGCTAC CTCTGAAGAG AAGGGCAGTT 000240
000241 CTCAGCAGCC TGAGGGGTGC TGGTAGAGAC ATACCAAAAG TGTTGTTGGT GCCACCTTTT TGCAAGAGAT GAAGAGAAAG 000320
000321 TTCC
Labs working on this lncRNA
- The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Ministry of Public Health; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine; Qilu Hospital, Shandong University, Jinan, China.
