FLICR
Contents
Annotated Information
Name
FLICR:FOXP3 regulating long intergenic non-coding RNA [1]
Characteristics
Flicr neighbors Foxp3 in mouse and human genomes [1].
Function
Flicr (Foxp3 long intergenic noncoding RNA) is a negative regulator that regulates key transcription factor FoxP3 expression in Tregs, resulting in twofold- to fivefold-lower levels of FoxP3 protein [1]. Flicr acts only in cis. It does not affect DNA methylation, but modifies chromatin accessibility in the conserved noncoding sequence 3 (CNS3)/Accessible region 5(AR5) region of Foxp3 [1]. As a result, Flicr curtails Treg activity, markedly promotes autoimmune diabetes and, conversely, restrains antiviral responses [1]. Also, this mechanism of FoxP3 control may allow escape from dominant Treg control during infection or cancer, at the cost of heightened autoimmunity [1].
Regulation
IL-2 can repress Flicr to ienhance Foxp3 expression [1].
Flicr's expression is also curtailed in conditions of heightened Treg activation and functionality, in tissue Tregs and after TCR activation [1].
Expression
Flicr is specifically expressed in Tregs [1].
Evolution
FLICR is highly conserved across mammalian species [1].
Sequence
>NR_147988.1 Homo sapiens FOXP3 regulating long intergenic non-coding RNA (FLICR), long non-coding RNA
000081 CTGGGCTTTG CAGGGTGCTG GGAGCT
Labs working on this lncRNA
- Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.
