LIF-AS1
Contents
Annotated Information
Name
LIF-AS1:LIF antisense RNA 1
ENST00000447565 [1]
Characteristics
ENST00000447565 is a LIF (leukemia inhibitor factor) natural antisense lncRNA [1].
Function
Lnc-LIF-AS can regulate the stability of LIF mRNA by over-lapping a 3′-UTR of LIF mRNA, which might contribute to inhibiting the degradation of LIF mRNA mediated by other RNAs [1].
Regulation
The expression ofΔNp63α can suppress the expression of Lnc-LIF-AS to inhibit LIF mRNA transcription and decrease LIF mRNA stability [1].
Expression
ENST00000447565 is significantly downregulated in SiHa/ΔNp63αstable cell lines, and shows gradual up-regulation with the increase of ΔNp63α siRNAs [1].
Diseases
Cervical squamous cancers [1]
Labs working on this lncRNA
- Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
