LINC01186
Contents
Annotated Information
Name
LINC01186:long intergenic non-protein coding RNA 1186
Characteristics
LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X.[1]
Cellular Localization
Comparison on the nuclear and cytosolic fractions of A549 cells shows that the LINC01186 transcript is mainly located in the nucleus irrespective of TGF-β1 treatment.[1]
Function
The bioinformatics analysis suggest that LINC01186 is associated with TGF-β and might participatein EMT process. In addition, knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis.[1]
Regulation
LINC01186 is regulated by SMAD3 and inhibits EMT.[1]
Expression
The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1. Furthermore, LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues in TCGA data sets and another published lung cancer datasets.[1]
Diseases
Lung cancer [1]
Sequence
>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA
000081 CCAGAAGTAA CCCCTTCTAA AACGGGAAAG ATGCCTTCCG AAAGCACTTG GCCCTAAAGA GAAAACACTA GGAGGATGGG 000160
000161 AACCAGGGAC AGAGAAGCTA CTTGCTCTGC AGCTGTTTGG GCCAGTATGT TCCCTAATCT TGATGGCCAT CCTGGGCTTA 000240
000241 TTTTCCTGAG AGTCTCTAAG TGACTCACTG CATCACGTAA AACTAAGAAA AAGGATGTCC TGAATTTTCC TGCTTAGAGA 000320
000321 GCTTGTTTTT CTTTCCTGTT GCATCAAAGG GGTCTGTTAA ACTTTCTAAA AGTACTAATC TGACCTGATA TCTGAAGTAA 000400
000401 CAGATAGGAA TTTGGGCTCT TTAAATGGAG CCCTTCCCCC ATACCTGCAT CTCATTGAAG AGGCTGAACT TCAAAACAAA 000480
000481 ATCATGTTGG AGAATTAAGT CTCGTTCCCA GATTTAATTT CTTATTTTTA TATTGTTGCA TAAGAAATCT ACTCTATAAG 000560
000561 GCATCTATTT TCAAATTTGG AAAATCTTAT TTTAAGTTCA TTTATTTAAA GACCAACAAA CAAAAACACC AAATTCACTA 000640
000641 GCCCAGGTCT TTATG
Labs working on this lncRNA
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
