SMILR
Contents
Annotated Information
Approved Symbol
SMILR
Approved Name
"smooth muscle induced lncRNA, enhancer of proliferation"
Chromosome
8q24.13
RefSeq(supplied by NCBI)
NR_131202
Characteristics
The longest open reading frame(ORF) within SMILR is 57 amino acids.
Localization of SMILR.(A)RNA FISH analysis of SMILR,cytoplasmic UBC mRNA,and nuclear SNORD3 RNA in HSVSMC.(B)25±5 individual SMILR molecules were observed within the nucleus and cytoplasm. [1].
Expression
SMILR is expressed highest in the heart and it is a differentially expressed lncRNA in human saphenous vein-derived smooth muscle cells [1].
Cellular Localization
SMILR locates in the nucleus and cytoplasm [1].
Function
SMILR regulates the expression of the nearby gene HAS2. Knockdown experiment shows SMILR is a driver gene and can regulate vascular smooth muscle cell proliferation [1].
Regulation
SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner [1].
pubmed IDs
27052414
Labs working on this lncRNA
- From BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom (M.D.B., R.D., L.D., R.M., R.G., P.W., N.S., M.W.N., R.A.M., A.H.B.); British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom (M.D.B., K.P., A.T.V., N.J., M.R.D., D.E.N., R.A.M., A.H.B.); Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, The University of Glasgow, United Kingdom (G.H.); and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.M.M.)[1].
- From BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom (M.D.B., R.D., L.D., R.M., R.G., P.W., N.S., M.W.N., R.A.M., A.H.B.); British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom (M.D.B., K.P., A.T.V., N.J., M.R.D., D.E.N., R.A.M., A.H.B.); Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, The University of Glasgow, United Kingdom (G.H.); and Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.M.M.)[1].
