LINC01186

Annotated Information

Name

LINC01186:long intergenic non-protein coding RNA 1186

Characteristics

LINC01186 is a ~600 nt long transcript, consisting of two exons, and originating from a locus of approximately 1.7 kb in the short arm of chromosome X .

Cellular Localization

LINC01186 transcript is mainly located in the nucleus .

Function

LINC01186 inhibits migration, invasion and colony formation.

LINC01186, regulated by TGF-β/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer . Knocking-down LINC01186 promots cell migration and invasion, whereas, LINC01186 overexpression prevents cell metastasis .

Regulation

LINC01186 is regulated by TGF-β/SMAD3. The expression of LINC01186 is significantly decreased in A549 cells treated with TGF-β1 .

Expression

LINC01186 is stably down-regulated in lung cancer tissues compared with normal tissues .

Diseases

Lung cancer

Sequence

>NR_110388.1 Homo sapiens long intergenic non-protein coding RNA 1186 (LINC01186), long non-coding RNA

000001 AGGCTAACAG AAACCCAGCC CTGCCCACTG GGTGAAACTG CAAGTCGAGA GCGTGGGAAA CCAGCAAGTT GAGAGAGGAT 000080
000081 CCAGAAGTAA CCCCTTCTAA AACGGGAAAG ATGCCTTCCG AAAGCACTTG GCCCTAAAGA GAAAACACTA GGAGGATGGG 000160
000161 AACCAGGGAC AGAGAAGCTA CTTGCTCTGC AGCTGTTTGG GCCAGTATGT TCCCTAATCT TGATGGCCAT CCTGGGCTTA 000240
000241 TTTTCCTGAG AGTCTCTAAG TGACTCACTG CATCACGTAA AACTAAGAAA AAGGATGTCC TGAATTTTCC TGCTTAGAGA 000320
000321 GCTTGTTTTT CTTTCCTGTT GCATCAAAGG GGTCTGTTAA ACTTTCTAAA AGTACTAATC TGACCTGATA TCTGAAGTAA 000400
000401 CAGATAGGAA TTTGGGCTCT TTAAATGGAG CCCTTCCCCC ATACCTGCAT CTCATTGAAG AGGCTGAACT TCAAAACAAA 000480
000481 ATCATGTTGG AGAATTAAGT CTCGTTCCCA GATTTAATTT CTTATTTTTA TATTGTTGCA TAAGAAATCT ACTCTATAAG 000560
000561 GCATCTATTT TCAAATTTGG AAAATCTTAT TTTAAGTTCA TTTATTTAAA GACCAACAAA CAAAAACACC AAATTCACTA 000640
000641 GCCCAGGTCT TTATG

Labs working on this lncRNA

• Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Beijing Key Laboratory of Noncoding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.