DM1-AS
Contents
Annotated Information
Name
DM1-AS:DM1 locus antisense RNA
Characteristics
DM1-AS spans >6 kb, contains alternative transcription start sites and uses alternative polyadenylation sites up- and downstream of the (CAG)n repeat [1]. Thus, a mixture of DM1-AS RNAs with and without expanded (CAG)n repeat are produced in patients [1].
Cellular Localization
DM1-AS transcripts are present in both the nucleus and the cytoplasm [1].
Expression
The DM1-AS transcript is a low-abundance RNA[1].
DM1-AS expression appears upregulated in patients, but transcript abundance remains very low [1]. Comparison among different tissues shows that DM1-AS expression is lowest in brain and highest in kidney, testis and muscle [1].
Diseases
Myotonic dystrophy type 1 [1]
Labs working on this lncRNA
- a Radboud University Medical Center, Department of Cell Biology, Nijmegen, The Netherlands.
