KRT7-AS

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Annotated Information

Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]

Approved Symbol

KRT7-AS (KRT7 antisense RNA 1)

Chromosome

12q13.13

RefSeq

NG_012296

Characteristics

KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]

Expression

In the same samples, KRT7 mRNA levels are much higher than KRT7-AS levels. In MKN28 and KATOIII cells, KRT7 mRNA is 61 and 41 fold higher than KRT7-AS (P<0.01).

Disease

gastric cancer

Labs working on this lncRNA

  • Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
  • Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

References

  1. 1.0 1.1 1.2 1.3 Huang, B., et al., Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene, 2016. 35(37): p. 4927-36.