KRT7-AS
Contents
Annotated Information
Expression pattern of KRT7-AS and KRT7 mRNAs in cell lines and tissues.[1]
Regulatory function of KRT7-AS overexpression to KRT7.[1]
Regulatory function of KRT7 mRNA downregulation to KRT7-AS and the rescue effect of KRT7-AS overexpression in KRT7 mRNA-downregulated cells.[1]
Approved Symbol
KRT7-AS (KRT7 antisense RNA 1)
Chromosome
12q13.13
RefSeq
NG_012296
Characteristics
KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.[1]
Expression
KRT7 mRNA levels are much higher than KRT7-AS levels in the same samples. In MKN28 and KATOIII cells, KRT7 mRNA is 61 and 41 fold higher than KRT7-AS (P<0.01).
Function
KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA Stability and protect KRT7 mRNA from degradation.[1] The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.[1]
Disease
gastric cancer
Labs working on this lncRNA
- Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
- Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
