LNCPRESS1
Contents
Annotated Information
Name
LNCPRESS1:lncRNA p53 regulated and ESC associated 1
Gene ID: ENSG00000232301
Characteristics
LncPRESS1 is an intergenic transcript [1]. It is 756 nt in length and is multi-exonic [1].
Cellular Localization
LncPRESS1 is primarily localized to nucleus [1].
Function
LncPRESS1 is a p53-regulated transcript that maintains hESC (human embryonic stem cell) pluripotency in concert with core pluripotency factors [1]. It safeguards the hESC state by disrupting SIRT6, which maintains high levels of histone H3K56 and H3K9 acetylation at promoters of pluripotency genes [1].
Regulation
Nuclear lncPRESS1 is regulated by p53-dependent alterations in chromatin state during differentiation of hESCs [1].
Expression
The expression of lncPRESS1 starts as early as the oocyte stage and is sustained to the morulae stage, with much higher expression in hESCs, suggesting that lncPRESS1 is highly enriched in the early stages of human embryonic development [1]. In addition, expression of lncPRESS1 is coordinated with pluripotency-specific genes and repression of lncPRESS1 during differentiation is largely controlled by p53 [1].
Sequence
>NR_146480.1 Homo sapiens lncRNA p53 regulated and ESC associated 1 (LNCPRESS1), long non-coding RNA
000081 GGGAACAGAA GGAGCCGGTA GGTTTTCACA CTTGCAGCAG ATCCGCTAAG AGAACGAGGG ATTCAGCCGA GAAGCCACTG 000160
000161 GGAGCCCGAG GAGTGGAGCA GAGGCACCCA GGCAGCCTGC GCGGAGAAAT CGGATCGGCT GGGACGGCCT GCAGCCCCCG 000240
000241 CGCGCGGGGA AAGGGAAGAA GTCCTCCCCT ACAAAGCGAA TTCACAAACG GAAGAAGTGA CTGTTCCACA GGATGCGCAG 000320
000321 ATCTCAACGG AAGGACCCAG GAGACATGAA AAAGCAAGGA AATGTGACGC CTTCAGAAGA AACCAGTAAT TCTCCAGCAA 000400
000401 CAGATCCCCA TCCAAAAGAA ATTCAGGAAA GCTCAAACAG AGAATTGAGC AGAGAATTGA CCGGACTGAT TGTAAAGAAG 000480
000481 GTCATCAACA TGGAAGAGTC TTTTGAACAA CAACATAAAG AAATGAGGAA AAGAGGTGGG GAGATATATG AGATGATTAC 000560
000561 CTGCCAGAAA GAGGTTTTAA AATTCAACAG AAGAGTATTT CTGGAACTGA AGAAATCATT GGATGAAATA CAAAGTACAC 000640
000641 TCAAAAGCTT CAATGATAGA CTAGAACAAA TAGAAGAAAA ACTCTCAGGG CATAAAATCT GAAGCATTTT TCTCACTTTA 000720
000721 AAGATTCATG GGTTGTACTC TGGCCATTAA TGTGAACAAA ACCTGCTGGG TTAGTTCTTA TTCTGGGGTC TTGGGTAATC 000800
000801 GTTAGAGCGA AATAAAAATA ATTTCCCTTA GA
Labs working on this lncRNA
- Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Stem Cell and Development Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell. 2016 Dec 1;64(5):967-981.
