MELTF-AS1
Contents
Annotated Information
lncRNA MFI2 is upregulated in human osteosarcoma tissues and osteosarcoma cell lines [1].
Knockdown of MFI2 suppresses osteosarcoma cell proliferation [1].
Correlation between MFI2 expression level and FOXP4 protein expression in osteosarcoma [1].
Approved Symbol
MELTF-AS1 (MELTF antisense RNA 1)
Previous Symbols
MFI2-AS1
Chromosome
3q29
RefSeq(supplied by NCBI)
NR_038285
Disease
osteosarcoma
Expression
Compared with corresponding adjacent, histological normal tissues, MFI2 was significantly upregulated in human osteosarcoma tissues (P<0.0001).[1] FOXP4 protein is upregulated in osteosarcoma tissues and positively correlated with MFI2 expression.[1]
Function
Knockdown of MFI2 inhibits osteosarcoma cell migration, invasion and proliferation. However,knockdown of MFI2 promotes osteosarcoma cell apoptosis in vitro.[1]
Labs working on this lncRNA
- Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, P.R. China.
- Department of Anatomy, Guangzhou Medical University, Guangzhou, Guangdong 510182, P.R. China.
