NONHSAT076153
Please input one-sentence summary here. PCGEM1 has been characterised as a high-risk PCa marker and a potential biomarker for neoplasms responsive to chemoprevention by phytosterols [1].
Contents
Annotated Information
Name
PCGEM1: Prostate-specific transcript, LINC00071 (HGNC)
Characteristics
PCGEM1 is located at human chromosome 2q32.3 (HGNC), consists of three exons that comprehends 1603 bp (GenBank).
Function
Over-expression leads to inhibition of apoptosis induced by doxorubicin [2]. t PRNCR1 and PCGEM1 successively interact with the androgen receptor (AR) bound at DNA-enhancer regions in a ligand-dependent fashion and facilitate the chromosomal looping between AR-bound enhancers and the promoter sequences of androgen-responsive genes [1].
Disease
prostate cancer
Expression
PCGEM1, was expressed exclusively in human prostate tissue, was dramatically upregulated in PCa tissues compared with normal prostate tissues. Prostate tissue-specific and prostate cancer-associated (Srikantan 2000). Cholesterols upregulate the expression of PCGEM1 even in androgen-insensitive prostate cancer cell lines while phytosterols reverse this effect (Ifere 2009). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation (Petrovics 2004). Low specificity as a biomarker for prostate cancer (14%) (Bialkowska-Hobrzanska 2006).
Conservation
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Misc
GWAS association with schizophrenia. PCGEM1 polymorphisms may contribute to PCa risk in Chinese men (Xue 2013)
Transcriptomic Nomeclature
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Regulation
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Allelic Information and Variation
PCGEM1 polymorphisms may contribute to PCa risk in Chinese men. Men carrying single nucleotide polymorphisms (SNPs) of PCGEM1, i.e. rs6434568 AC and rs16834898 AC, had a lower PCa risk in comparison to the ones harboring CC and AA genotypes, respectively [3].
Evolution
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Labs working on this lncRNA
Howard Hughes Medical Institute, Department of Medicine, University of California San Diego, La Jolla, California 92093, USA. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. Department of Urology, School of Medicine, University of California Davis, Sacramento, California 95817, USA. Graduate Program, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, California 92037, USA. Bioinformatics and System Biology Program, Department of Bioengineering, University of California San Diego, La Jolla, California 92093, USA. Neurosciences Graduate Program, Department of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA.
References
- ↑ 1.0 1.1 Martens-Uzunova ES, Böttcher R, Croce CM, Jenster G, Visakorpi T & Calin GA. Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer[J]. European Urology. 2014, 65(6):1140-1151.
- ↑ Fu X, Ravindranath L, Tran N, Petrovics G & Srivastava S. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1[J]. DNA and cell biology. 2006, 25(3):135-141.
- ↑ Xue Y, Wang M, Kang M, et al. Association between lncrna PCGEM1 polymorphisms and prostate cancer risk[J]. Prostate cancer and prostatic diseases, 2013, 16(2):139.
Basic Information
| Transcript ID |
NONHSAT076153 |
| Source |
NONCODE4.0 |
| Same with |
, |
| Classification |
intergenic |
| Length |
1603 nt |
| Genomic location |
chr2+:193614571..193641625 |
| Exon number |
3 |
| Exons |
193614571..193614754,193615515..193615598,193640304..193641625 |
| Genome context |
|
| Sequence |
>gi |
