NONHSAT091315
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Contents
Annotated Information
Name
TUSC7: Tumor suppressor candidate 7 (HGNC nomenclature), LOC285194 [1].
Characteristics
Together with the noncoding RNA BC040587 and the tumor suppressor gene LSAMP (limbic system-associated membrane protein), LOC285194 is present in the focal region of chr3q13.31 (osteo3q13.31), which is the most altered region in osteosarcomas. These genes are proposed to be cooperatively acting tumor suppressors [1].
Features
Recurrent focal copy-number changes and loss of heterozygosity (LOH), which usually involves loss of LOC285194 and BC040587 expression, implicate these ncRNAs in ostecosarcoma. Focal osteo3q13.31 CNAs and LOH are also common in cell lines from several other cancers (such as lung, autonomic and central nervous system, blood, endometrium, soft tissue, skin, gastrointestinal tract, urinary tract, and breast).
Depletion of LOC285194 by siRNA promoted proliferation of normal osteoblasts (with a mild increase in the G1 population) by cell-cycle transcripts (Cyclin D1, VEGF, and VEGFR1 up-regulation, and cyclin A2 and cyclin B1 suppression) as well as regulation of apoptotic genes (such as suppression of BCL2 and BimEL pro-apoptotic genes).
Genetic deletions of LOC285194 or BC040587 in tumor DNA were also associated with dramatic decrease in survival of osteosarcoma patients.
Function
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Expression
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Conservation
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Misc
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Transcriptomic Nomeclature
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Regulation
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Allelic Information and Variation
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Disease
Labs working on this lncRNA
- Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.[2]
- Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.[2]
- Institute of Pathology, Fudan University, Shanghai, 200032, China.[2]
- Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.[2]
References
- ↑ 1.0 1.1 1.2 Pasic I, Shlien A, Durbin AD, Stavropoulos DJ, Baskin B, Ray PN et al. Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13. 31 in osteosarcoma[J]. Cancer research. 2010, 70(1): 160-171.
- ↑ 2.0 2.1 2.2 2.3 2.4 Qi P, Xu MD, Ni SJ, Huang D, Wei P, Tan C et al. Low expression of LOC285194 is associated with poor prognosis in colorectal cancer[J]. Journal of translational medicine. 2013, 11(1):122.
Sequence
>gi|285194|ref|NR_015391.1| Homo sapiens tumor suppressor candidate 7 (TUSC7), long non-coding RNA
000081 TTGCTAGAGG TAGGAAGATG ATAAGATCAG TTTCTATAGG TAGAGGATAA TGTGTCCTAA AATGTAGGTA GAGATAAGTC 000160
000161 TGACAGTGGT TTAGACAAAA AGGGCCTCTG CTAATGGTGG AGAGATCAAG GAAGAAAAGA GCAACGTTAA AGTGAGGCTG 000240
000241 TACCCACAGA TCATGCTCAA GCAAATTCGA ACCGTGAGCG CATTTCTCTT AAACAATGAA CACTTAGAAT AAAAATTAAA 000320
000321 ATTTCCCACA AATTTCTAAT TTTAAAATAG TTTCCCAAGA TTTCAGTGGT ATTGTATATA TGCCCATATA ATTTTTTGGA 000400
000401 TTACTATTCC CACAAGTGTA AGATGAAAGA GGACCTGCCC TCCATTCTAT CTACTCCCTC TCTGCAAAGG CCATTTTGAA 000480
000481 GATCTCAGTT TTACTGAAAG GGGTCTGCCA CACATAACTT CCCTGGTGTA CCAGCAACAA GTGTTCAGTG GACCATGGCA 000560
000561 ACACAAAGAA TGACGGAGGA GAGAAAATGC CATGCAGAAG TGATAGTCAA GATGAAGATG TGGGAGAGGA GCAGCCCCCA 000640
000641 GTATATATTC AGTGTGTCCT CTGAAGTAAC AACCATCCCA TCTGGCTGAG AAGTGATGGA CACGGCTCCT TAACCACACT 000720
000721 GTACCCTCTG TTCTTGGCAC CTCTCTACCA GAAAGATATC AACAAATTGG ATGGAATTCA GAGAACAGTA AGAAAAATGA 000800
000801 TTAAAGAGAT GGAGGCAGTG ACTTATGAGG AAAGATGAAA AGGACTAAAT CTATGTAGCT TGGCAAAGCA ACAACTGAGG 000880
000881 TGGCGTATGA AAACTGTCTA CAAGCATTTG AAGAATATAA ACACCAAGGG AAGAGAGGGA ACTTTTTAGA ATGGTCTGGG 000960
000961 GAATAAGCAG AGTAAGAGGA CAGAATTGAA GAAAGGAGAG AGATATGCTA AGTTGGGGGT GGGGGCGTTT TCTCATCAAT 001040
001041 TGTAAATTTT GATAAATAAC AAAATTAAGT CTGGAGAGAA AGAGTTGCAT CTCATGCTTT TAGGTTACAA TCAGTGTTGA 001120
001121 CCTGCACTGA GAAAATGTGA CTTCCTATTA TCCTTCTCAA AGTTATTGCT GCAGAGGAAA GAAGCATACA TCTTTTACCC 001200
001201 ACCAGGAAAC CCCCAAAGCA TCTATTACCA TAATAGCCAT GGGAAACAGA AGGCACCTCA AATAAAGGTG GGGAAAAGAA 001280
001281 TGAAAGAAAT GGCTTTGGCC TGTGCCTGTT TGACCTCTGA GAGATACTTT TTGCAAGAAA TTGTTAAGTT TTGGCCCAAA 001360
001361 AAGTGGTCGG TCTTTTATCC TTCCTTGTGG AGGCCAAACT GCAAACCAGG ATGAAGAAAC CATCAGTGGC AGTTTGGGGA 001440
001441 GGTGGAGGAG GGACTATCTA GACTCAGTGA ATCACCAAGG AAACATGAGG CCTATTTCTC TGTGAAGCTG AACTTCAAAA 001520
001521 AACAATCTAA GAGATACAAA GGGAAAAGTG TGACTGCTCT GACAGCAAAA ACAAGCAAAT ATCTCCAGAG GGGATTAATC 001600
001601 CTTCTGCTTC AAAGTAACTA AAACAAAGAA AGCTGAGCCA GCTTCACTGG AAACAACACC TGTCCATCAG ACAAGGATGA 001680
001681 GCTAATCAAA AGAAAACACT GCCTATGTGC ACGACTCAGC AGCCTGGACA GCTAATACCA AGGAACACGT TTTCACTATA 001760
001761 AAGATTCAGC TTTCAAAATC CAGTTCCCTC TTGTAGAGCC ACAGGGTTAA AAGGGACCTT AGAGATCATC TACATACAGG 001840
001841 CCAAACCCTC AATGAATGCC AGTGTTCGCC TTATGTTCTT CTTGCCGGAC TCTTTTCTGG CCTCTGTTCT GTCAGGATGT 001920
001921 TTCCTGTTTT GCAAAACAGC TTTAATCCTT GAGTATATTT AATTGTTAGA AAACAGTTCC TCAAATTTGA CCCCAAATTT 002000
002001 AAGTCTAATT TATGAAGAAA GTTTTGCCTT TGGAGACAGG TTTAATTTTA CTTCCATGTG GAAAACCTTC AAATAAAATG 002080
002081 ATGACTATTG TGTACTCACG AAAAA
Predicted Small Protein
| Name | NONHSAT091315_smProtein_554:688 |
| Length | 45 |
| Molecular weight | 5090.8545 |
| Aromaticity | 0.0681818181818 |
| Instability index | 79.2 |
| Isoelectric point | 7.94122314453 |
| Runs | 9 |
| Runs residual | 0.0414438502674 |
| Runs probability | 0.0412569432178 |
| Amino acid sequence | MATQRMTEERKCHAEVIVKMKMWERSSPQYIFSVSSEVTTIPSG |
| Secondary structure | LLLLLLLHHHLEEEEEEEEEEEEEELLLEEEEEELLEEEEELLL |
| PRMN | - |
| PiMo | - |
