HSALNG0007045

FALEC, FAL1 is an oncogenic lncRNA that promotes cancer cell growth in part via repression of p21.

Annotated Information

Approved Symbol

FALEC

Approved Name

FALEC:focally amplified long non-coding RNA in epithelial cancer FAL1; ncRNA-a1; LINC00568

Characteristics

a lncRNA in a focal amplicon on chromosome 1q21.2

Function

FAL1 associates with the epigenetic repressor BMI1 and regulates its stability in order to modulate the transcription of a number of genes including CDKN1A The up-regulation of FALEC is connected with the poor prognosis of patients with melanoma ref2 t FALEC could accelerate the proliferation of melanoma cells through influencing the cell cycle and apoptosis. ref2

Knockdown of FALEC blocks the metastasis, invasion and EMT process ref2
LncRNA FALEC is negatively correlated with p21 in melanoma tumorigenesis re2
FALEC epigenetically silences p21 via binding to EZH2 ref2

Diseases

• Hepatocellular carcinoma ref3
• Ovarian carcinoma ref2
• Prostate cancer ref1
• Thyroid cancer ref4

Expression

FALEC is highly expressed in melanoma tissues and cell lines ref 2

After stratifying the 128 late-stage ovarian cancer patients with FAL1 RNA expression (cut-off, median expression) or gene amplification status, we found that both higher expression of FAL1 RNA and genomic gain of FAL1 gene were significantly associated with decreased survival in patients (p<0.0001 and p=0.03, respectively,

Labs working on this lncRNA

• Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China
• Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
• Center for Research on Reproduction & Women’s Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
• Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA