PICART1

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PICART1, a long noncoding RNA that mediates cancer cell proliferation and migration

Annotated Information

Approved Symbol

PICART1

Approved Name

PICART1: p53 inducible cancer associated RNA transcript 1. AC009720.1. NR_038230. LOC84080.

Characteristics

PICART1 lncRNA consists of 3 exons, 2533 bp in length (gene ID: 284080) and is encoded by a gene located at 17q21.33. [1]

Function

PICART1 inhibited cell proliferation and migration in breast and colorectal cancer cells through suppression of the AKT/GSK3β/β-catenin signaling pathway, functioning as a tumor suppressor. [1]

Regulation

PICART1 was found to be upregulated by p53 through a p53-binding site at -1808 to -1783 bp. [1]

Diseases

  • Breast cancer [1]
  • Colorectal cancer [1]
  • Lung cancer [2]

Expression

In breast and colorectal cancer cells and tissues, PICART1 expression was found to be decreased. [1] Ectopic expression of PICART1 suppressed the growth, proliferation, migration, and invasion of MCF7, MDA-MB-231 and HCT116 cells. [1] Silencing of PICART1 stimulated cell growth and migration. In these cells, the expression of PICART1 suppressed levels of p-AKT (Thr308 and Ser473) and p-GSK3β (Ser9), and accordingly, β-catenin, cyclin D1 and c-Myc expression were decreased, while p21Waf/cip1 expression was increased. [1]

Labs working on this lncRNA

  • Department of Medical Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62794, USA, University of Missouri-Kansas City, Kansas City, MO 64108, USA

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Cao Y, Lin ML, Bu YW, Ling HY, He YC, Huang CF et al. p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration[J]. Int J Oncol. 2017, 50(5):1671-1682.
  2. ↑ Zhao JM, Cheng W, He XG, Liu YL, Wang FF & Gao YF. Long non-coding RNA PICART1 suppresses proliferation and promotes apoptosis in lung cancer cells by inhibiting JAK2/STAT3 signaling[J]. Neoplasma. 2018, 65(5):779-789.

Sequence

>gi|284080|ref|NR_038230.1|Homo sapiens p53 inducible cancer associated RNA transcript 1 (PICART1), long non-coding RNA

000001 GCTGCTGCTG CTGAAAAGGC CAGCCGGGCT GGAGAGACCT GGCATTGGCG CATCTGGGAA CCGACGTCCG TGCGCGGCTG 000080
000081 GCTAGAATGC TGGACTCGCC TCCGCAGCGC TGGCCTGCAG GGATTAGAAG ACATGTGGGG TCAAGGAACA GGAAGCTGAC 000160
000161 CTGGATGGAA GTTGAACAGT GATCTTTGCT CTCTGCCTGG CTCCTGAGTC CTCTGCCATG TTCCTGGAGA AGAGGAGCCA 000240
000241 GCCAGGTCTT CATTCAAACC AAACCTTGGA TGGGATCCAT CTGCCTCTGC AGGTGACCGT AACAACATGC AAATGGTGAG 000320
000321 TTCTGCTGGG GGGTCATGGA AGCTCCCTGG AGGAGGTGTA TCTGGACAAC AGGGAAAGAA AGGAGCTGGA GAAGAGAGGC 000400
000401 AGAAAAATTG GGTCCTGGTT CAGGTGAAGT TTTCCCAGCT GGAACAATGA CAATGTCAAT ATCCCACAAA GGCGGCTTCT 000480
000481 GTTTATTTAG CGCTTGCTGT GTTCCCACAA GTCTTCCTCT ACCTGCCCTC TCCCCAGCCC TCATCTCACT CTCCCAGAGC 000560
000561 CCCAGAGCAC ACCAATGGAC ACCATCACCT CTCGGGCAGA TCAGCACAGA GACGTGAAGC ACACAGGCAG CTGCTGGAAA 000640
000641 AATAACAAGG AATTGCAATG GTGTGCCCCT CCGTTGAATG CAAGCTCTCT TCTGCCTTCT CACCTTGGGC AAGTTACCTT 000720
000721 CCGTTCCAGG CCTCGGTTTC TCCATGTGTG AAATGAAAGG GCTGGAGAGA AATCTCTCAC TATTCCCCAA TCTACATTCA 000800
000801 TTGTATCCCA AACCTTCTAA TATCTGTTCA ACGAAGTGTA CCAAATCTCA GCTATTGGAC TGAGACTCAG GGGTCTATCT 000880
000881 GACTTGAATT GAAAATGCAA ATTACTGAAG AGGGAGGGAG GGAGGAGTGC TGAAGATTGA ATGGATTTAT CAGATTTCCT 000960
000961 TCTCCTATGG CCCAGATGCA GGCCTAGTCC AGGCGATTCC CCTGGCTCAG AATCTGCCAG GCTCAAGCAT TCATTGACAG 001040
001041 CCTACTATGT ACCAATCCTG GGCTGAGTCC CAACCCGGGG ATGACTTAGA GGAGGCCAGG ATGTGGCCTC ATGTTCTGGT 001120
001121 TGCTCTCACA TTTAAACAGG CTAAACCCAC TTTGCATTGT ATGTTAGGGG TGGTGCTTGT GGGACAAAGG GGGCTGTCAG 001200
001201 AACATTCTGG CTGCCACATG AAGTTGACTT TGCCAGGACA GACTGGGTTG TGGGGGAAGG CAGCTACTGT AATAATTTGG 001280
001281 CCAAGAAGTG GGCTGAGCAG GAGCAGGGCT GAGGGAGGGA GAGAGGGAAT GAGTAAGAAA GGCCCAGGGT ACTGATTTGA 001360
001361 CTGGGACTTC AGGGACAGGT GTGGGGCGAG AGGGATGCTG GAAGTGAAGG AGGGAAAGTG CAGAGGCTTT CTGGGGATTA 001440
001441 ATAGGCAATG ATCTCTATGA GGGCGTGGTG AGTAGGCCCC AAACATCCGG GGACTTCCCT GCCTGCCATC CCTCTGTCTC 001520
001521 TCTCTTCCTT TCCTACTGCC CAGGGCCTGG CCCTGCTGCA CATGCCCTGC CCTGGCCCCC AGAGTCCCCT TCTTTCCTGG 001600
001601 CTGGGAGATT AAGACTCTGC TGTGCCTACA GCATTCTCAA CCTCAAGTCA AGGTGGCCCT TTGGAGCCCA GGAGGCCACA 001680
001681 TGGCTGAGTC AGGGCTGAGT CACCACCCCC CAAGGGCCTT GCCATTTCCT GTGGAGAAGC CTCTTTACTG GCAGGGTTCT 001760
001761 GTGCTCAGGT GGGAAATCTG GAGAGGTCGG GGGCAGGGCT TCATCTACTT TTACCCACTA ACTCCCTAGA CACTCCACTG 001840
001841 GGGGTAGAGG GTTCCTACAC GTATGATGAT CAAAACATGT GTCTGTGCAC ATGGGCCCTT ATGCATTCAC AGGTGTTTGC 001920
001921 CTATGCGACT GCATGTCTGA ATGTTTTATG TATATTTGAA TATAGATAGG GAACAAATAT TTATGGAGCA CATATTATGT 002000
002001 GTGCAGCCTT TTACGTGTGT TACTTTCTAA TAACCCTAGG AGGCGTAGAT GCCTCCCAGG CTATGGTTGA AAATACTGAC 002080
002081 ATGCCCAAGG TGCAGGAGGT ATGAATACCT CCCCACTGTG GCTGGTAACA CCCCAGGTTT CTCCAACTCC ACAGTGATGG 002160
002161 GCTTTCC