LNCOG
LNCOG, Promotes the Osteogenic Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells
Contents
Annotated Information
Approved Symbol
LNCOG
Approved Name
LNCOG: lncRNA osteogenesis associated, LINC02407, RP11-54A9.1, lncRNA-OG
Characteristics
LNCOG is located on human chromosome 12 between the NAP1L1 and BBS10 genes [1]. LNCOG contains four exons, comprising 878 nucleotides, at a modestly conserved locus according to Phylop analysis [1]. LNCOG is mainly located in the nucleus of BM‐MSCs which indicates that LNCOG may exert its biological function in the nucleus [1].
Function
LNCOG is a functional osteogenesis‐associated lncRNA that significantly promotes BM‐MSC differentiation into osteoblasts by regulating the expression of BMP family proteins via interactions with hnRNPK [1].
Regulation
hnRNPK increases LNCOG promoter H3K27 acetylation to promote LNCOG transcriptional activity [1].
Diseases
- NA
Expression
LNCOG is expressed in the process of BM‐MSC osteogenesis [1].
Labs working on this lncRNA
- Center for Biotherapy, Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University, Guangzhou, People's Republic of China
- Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat‐sen University, Shenzhen, People's Republic of China
References
Sequence
>gi|105369848|ref|>NR_146531.1|Homo sapiens lncRNA osteogenesis associated (LNCOG), long non-coding RNA GAGCATTCTGTAGCTGTATTTTACAGAACTGTAATTGCACAGATTGTTCCTCTTACAAGAGAAATATCCA GAGCTCTAAGAAAACAACTGATGAAAACGACATGCGTGACATTTGGTGCTGAAGACCCAGGTCAGAGAGA CTCCTTTGGGGGACCAGTCCGCTGTCCTTGCCCTCACTCTGTGAGGAGACCCACCTACGACCTCGGGTCC TCAGACCAACCAGCTCAAGGAACATCTCACCAATTTCAAATCGGGACCCCACTGGAAAATGGACTGTCCA ACTCACCCGGCAGCCACTCCCAGAGCCCCTGGAACTCTGGCCCAAGGCTCTCTGACTGACTCCTTCCCAG ATCTTCTCGGCTCAGCAGCTGAAGACTGACACTGCTTGATTGCCTGGGAAGCCTATAGGACCATCACAGA CACTTTGGATAACTCTTACAGTGAAGGACAAAAAAGCGCCACTGCAGGGAGGAATGCCAGGGTCCCATAG AGGGAGACCGACAGTGAAGTGGAGCCTGCCATGAATTCACCAAAGGCCATTCTCCCTTTCTTCCAGAAGA ACAGCATTTAGCTGGGCCTATGGCTACCTACCTAAAGACTGCACCTCTTAGTCACCCTTGTGGCCAGGTG TGGCCACGTGACAGTGGAATGTAAGTGGAAGTGATGTATGCACTTGGGTTCATTGGTTTAAAAAAAAATA TGACCGCCCTCCATTTCCACTCTTTGTCTTATCTGTGAATGGGAACATGGCTGTGTCTGCAGCCCGACTT TGTGCAGCAAAGGACAAGGCCCTAGGGGAAGGTGGAGAAACAAGATGGAACAACTTGGACCCAACAACTT GGATCCCTATGTGGCCATGTGGAGTCATCTCACCCACCTGGGCCACTCACCCCGAAGACTGTTGTGTGAG GGTGAAATAAACTTCTGTATCACTAGCCCCTGCATTTCAGAAATTCTTTGTTATGGCAGTTTTGCCTTTA TCCTAACACAGACAGCAAAGTATCTTCTGTGGCCCCATGACTAATTTCGTTGTTTAAACTCATTATAAAA ACTATATAAATAAAATATTAAAAATCAAATAAAATAGCAAGATAACACTGTGTAACTATCCAGTTTTAGA TGTTATTACCTTTTTGGCATATTTACCTCATCTATTTTCTCCAGGGGTTTTTAAAGAAGAGTCATGCTTG TTATTTTAAATTATCTGCAGTGCTCCTTGGTCTTATAAAACTATGGGTTATTTCAAACTTCGGTAAATGT CTGATACACATGAACTTCTTGCATTGTTGAGGAAATCAGAGAAAAATGATGCTGTTTTTCCCTTGTAAGT TGACAATGGATGGAGATGAAACCACCTTTGCAAAATTATGGCAATAAGAGAAATTGGACATGGCAGACTC CATCTTGCTTTTAGCCTCACAGGTTGGCTGTCTTGGCTCATTCCTGGGCATAAGCCAAGCTAACTTTGGC AGAAATTGAGTTTATAGTGTAAACGATAATAGCCTTTCCCCAAAACTAAACTACCCTTGTAAAATTAATG AAAGGCCACCAAGTTAGGAGGATGAGAAGGGCCTGAATGCCTGAATTCAGCCATTATTCTGGAAGTCACA AGATGTGCAACCTCCCCAGTTACTCCTGTAAATAACTTCAGTATTGTAGAACCTAAGATTGGCCTTTTGA CAGCCTTTTGCATTTCTGACAACTAGATGGCCCCACGCAGACCCGTGACTCAACCAGTCCTATAGCCTTC ATCCAAAAATGGACTCAGTGCATGAGGACTGTTTTCCACACCCTTATGATTGCATCCCAAACCAATCAGC AGCACCCATACCCTATCCCCTGCACACCAAACTATCTTTGAGAAACTCCTAACCTCTGATTCTTTGGTGA GATTGATTTAAGTAATAACTCTGTCTCCCACATGGCGTGGCTGGCGTCGTGTC</dnaseq>
