LINC00958
LINC00958, long intergenic non-protein coding RNA 958 has been termed as an oncogene in bladder cancer and also has an oncogenic role in gliamogenesis.
Contents
Annotated Information
Name
LINC00958: long intergenic non-protein coding RNA 958 (HGNC nomenclature). LINC00958: long intergenic non-protein coding RNA 00958 (HGNC nomenclature) [1].
Function
RNA pull-down and RNA immunoprecipitation (RIP)shows that LINC00958 likely acts as an oncogenic driver contributing to an aggressive cancerous phenotype likely through interaction with proteins involved in initiation of translation and/or post-transcriptional modification of RNA [2]. Results indicate that LINC00958 may exhibit oncogenic properties by promoting proliferation, migration and invasion and hence may play a role during the metastatic process of BC cells [2].
LINC00958 acts as an oncogenic gene in the gliomagenesis through miR-203-CDK2 regulation, providing a novel insight into glioma tumorigenesis [1].
Regulation
LINC00958 binds proteins involved in regulation and initiation of translation and in post-transcriptional modification of RNA, including Metadherin, which has previously been associated with bladder cancer (BC) [2]. LINC00958 regulates glioma carcinogenesis through modulating proliferation, invasion, and cell cycle regulation ref name="ref2" />.
Diseases
Expression
LINC00958 is significantly down-regulated in breast and prostate cancer [2]. lncRNA LINC00958 is upregulated in glioma tissue and cells [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| RT PCR | 5′-CCATTGAAGATACCACGCTGC-3′ | 5′-GGTTGTTGCCCAGGGTAGTG-3′ '[1] |
Labs working on this lncRNA
- Department of Molecular Medicine, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark. [2]
- Department of Urology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany. [2]
- Research unit for Molecular Medicine, Department of Clinical Medicine, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark [2]
- Department of Molecular Biology and Genetics - Genome expression, stability and technology, University of Aarhus, Aarhus, Denmark.[2]
- Department of Urology, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark. [2]
- Department of Neurosurgery, The Second Affiliated Hospital of Hebei Medical University , Shijiazhuang, Hebei, China. [1]
- Department of Neurosurgery, Armed Police General Hospital , Beijing, China. [1]
- Department of Neurosurgery, Central Hospital of Handan City , Handan, China. [1]
- Department of Surgery, People's Hospital of Nanhe , Hebei, China. [1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Guo E, Liang C, He X, Song G, Liu H, Lv Z, Guan J, Yang D, Zheng J. Long Noncoding RNA LINC00958 Accelerates Gliomagenesis Through Regulating miR-203/CDK2[J]. DNA and cell biology. 2018, 37(5):465-72.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Seitz AK, Christensen LL, Christensen E, Faarkrog K, Ostenfeld MS, Hedegaard J, Nordentoft I, Nielsen MM, Palmfeldt J, Thomson M, Jensen MT. Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer[J]. Scientific Reports. 2017, 7(1):395.
Sequence
>gi|100506305|ref|NR_038904.1| Homo sapiens long intergenic non-protein coding RNA 958 (LINC00958), long non-coding RNA
000081 GCCATGCGGA ACGCTGTAGA CCAAGACCTG GAATTAACAC ATCAGAAGAT TCTATGAGGA AACCCATTTA AAAATAGGAT 000160
000161 GCATTTTTTT CTTTTCTGCA CAGGGAGAAA GTTTAAGCTC TCCTCACTAT GAGTTTTCAA GTATAAAAGA CTTTTTCTTC 000240
000241 CACGATTTTG AGAACAACTG AGGACTCTTG TGACCAGGAC AACAGGGAAG CTTGCAGCAA GATAGCTCCA GGTTGGATTC 000320
000321 ATGCTTCGCA CCCCAAGGGC TGCCAGCCAG AGAGGAGGAG AAGCAATCAC TCCTGCAGTT TCTGAACACT ACACAGACGC 000400
000401 CAGGTAGCTT CTTCAGGAGA ACAGCCCTCT GAGGAGGCAG GAAGAGGAGG CTTATCTTTC AGCAGCCGGA GCTGCTGAGA 000480
000481 TCTCTGGGCA GATTAAGCTC TCTCTAATGG ATGGGCTCCA GCCTGGCACA TTCAGTGGAG AGGGATCCAC TCATCCATCA 000560
000561 TCAACATAAT ATGGTCCTCC CTGCACTTCA CAGTGTCCTC TTGCTATTGA AAAGGCTTTT TTGCCTTCTC AAGTTTCTTT 000640
000641 GTCAACAGTC TACAGGAAGA AGCTCAGGCC GCCACCGGCA GAGGTGAATG CAAGCTCACG TTTTATTTCT GACTGCTTAA 000720
000721 TCATTGCCTC GATCACTGCT CAAGCTCTGC CTTTGTTTCC AAAGGTTACC TGTGGGAAAA CTTCTTTTTC TATGCTGAAA 000800
000801 TTAATAGGGA GGCAAAGATG AGTCCACTGA TAAGCAGAGC CTTAAAACTC ACATAGAGAA ACAACTTTGC TGGAGTGTGT 000880
000881 GTGAGTGAAC CACTAAGGAA TCAGATAGTG TGATGGCAGT TATCATTGCA GGTTAAGACA TTTCTACAAA TATTTCGACA 000960
000961 TCTCCATATA CTCACTCCTT TCCCCCCTGA GTGGAGAGAC TCAGCTACCA AGAGAGGAAG CTCAAAAAAA ACAGAAGCTT 001040
001041 CAAACAAACA ACCAACCAAA AAAAAAAAAA AACTGTGGGT TCATCAGAGG TGGTAGGGAA GACAAAAACA TGGGAGGAGC 001120
001121 AGCTGGGCAC GGTGGCTCAA GCCTGTAATC CCAGCACTTT GCGAGGCTGA GGTGGGTGGA TCACCTGAGG TCAGGAGTTC 001200
001201 GAGACCAGCC TGGCCAACAT GGTGAAACCC CATCTCTACT AAAAATACAA AAAATTAGCC GGGCGTTGTG GTACGCACCT 001280
001281 GTAATCCCAG CTACTCCGGA GGCTGAGGCA GCAGAATCGC TTGAACCCAG GAGGCAGAGG TTGCAACGAG CCAAGATCGC 001360
001361 ACCATTGCAC TCCAGCCTGG GCAACAAGAG CGAAACTCCA TCTAAAAAAA ACAAACAAGC AAACAAACAA AAAACACGGG 001440
001441 AGGAGCAATA AAAAGGAATC CATGCTTTGA TTTTTTTTTT TAGTGAGAGG AAGGGAAGGC TGCTGCCTCT CACTTCTCCC 001520
001521 TGTTTTGTTG TTCTTTTAAG TAGCATGTGT CACTCTGTAA AAAAAAAAAA AAAAAA
