NKX2-1-AS1
NKX2-1-AS1, negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration
Contents
Annotated Information
Approved Symbol
NKX2-1-AS1
Approved Name
NKX2-1-AS1: NKX2-1 antisense RNA 1
Characteristics
Human antisense lncRNA NKX2-1-AS1 partially overlaps the NKX2-1/TTF1 gene within chromosomal region 14q13.3 [1]. Amplification of this region and/or differential expression of genes therein are associated with cancer progression [1].
Function
NKX2-1-AS1 inhibits cell migration but has no significant effect on proliferation, invasion or apoptosis [1]. NKX2-1-AS1 interacts with NKX2-1 protein [1]. NKX2-1-AS1 inhibits transcription from the CD274 proximal promoter and reduces NKX2-1-mediated activation of CD274 transcription [1]. NKX2-1-AS1 impairs binding of NKX2-1 protein to the CD274 gene promoter [1]. NKX2-1-AS1 negatively regulates PD-1/PD-L1 signaling and adherens junction pathways [1].
Regulation
NKX2-1-AS1 transcripts can be initiated at multiple transcription start sites [1].
Diseases
- Lung Cancer [1]
Expression
NKX2-1-AS1 is highly expressed in primary lung adenocarcinomas compared to squamous carcinomas11,21,23 and in some small cell carcinomas [1].
Labs working on this lncRNA
- The Pulmonary Center, Boston University School of Medicine, 72 E. Concord St, Boston, MA 02118 USA
- Clinical and Translational Science Institute, Boston University School of Medicine, 72 E. Concord St, Boston, MA 02118 USA
- Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 E. Concord St, Boston, MA 02118 USA
References
Sequence
>gi|100506237|ref|NR_103710.1|Homo sapiens NKX2-1 antisense RNA 1 (NKX2-1-AS1), long non-coding RNA
000081 GATTCGGCGG CGGCTGGAGG AGGAAGGAAG AGGAGGAAAA AAAAGGGAGA GGGGGAAGGC GAAGCCTCGC TGCTTTTTTT 000160
000161 TTCTCCCTTT GCCAAATATT CTGGTGTTAC CTTAACGCCG ATCTTGTTGG ATGTACACGT AACGGAGTGG ACCGAGTCCT 000240
000241 CCTTAATTGG CTTGAGTGGA GGCTCGGGGG CTGCCTCGCG TTTGTTTTAG CCCGGCGCCA GGTTTTAGGC AGCCACCAGA 000320
000321 GGCGGGGCGT AAGCGCTAAA GCAACAAGAC AATAGAAGCC TACATCTTGC CCGAGATAAT TAGCTTACAT GCTGATGACA 000400
000401 AGGGTAAAGA AAGCTCAGGA CACCCTCCGC CCTCCCACCT GCGCCCGCGT TTTTGTGCGG TCCCCACGGC AGAGCTGGGG 000480
000481 AGGCCACCCT ACGTTTGCGC AGGGAGACGC GCTCGCCGCT GGTGTTGCGA AAGACCAGAG CGAAGCCCGG CTCCTTGCCC 000560
000561 TTCCTTCCCA GGGGCTTCTC TGGGGGGCGC TCTCAGGCCC CGACGAACTG AGCATTGATC ACTGTGGTGG CTAAGCAAGG 000640
000641 AGGGGAGGCG ACGCCGGGCT TAAGCGAACC ACAGAGGAGA ACTGGCAACG CTGAATACAG ACCTTGTCTG CAGGCGCGAC 000720
000721 CTGGCCGGGC CTGAGTCCCG AATGGGGTCT AATTGCGAAG GCGGGGTGGG TTTCCCAGTC ACCCAGCTTC TTTCTCTCAC 000800
000801 TCGCCATTAT TTCATAGTTG TTTGTAAGTT TAAGGAACAC CAAGTGTAGA ATGTTGTACA TCTCTTCCAG TCTCAACGCC 000880
000881 ATTTAGAAAT GGAGATCAAT CTTCACAAGG TTTTTGTGAG ATTCAAGTAA GATGAAGCAC ATCAAAATGC TTTGAAAGCT 000960
000961 TTGAATGTTT TTCAGCTCAG TGCCAGCACT GGAGATTGCG GTAGTTATTA TCATGACTAT CCCCACCCCC TCTTAGGTCC 001040
001041 CAAGACCTGA GTAAAAGGAA GAGTTGGGTG AATCTTCCAC AGCCCCTAGG TCCTGTCTTC TCGGCCTTCG TCCCTTGGCA 001120
001121 GCTTTTCAAC CTCTCAGCAG GCCACAGGCG CACGTGGCTG GCAGCTCCCC GGCCTCCGGC TCTGACAGTC CGGGGGCAAC 001200
001201 CAGGCCTGCA GTTCTCGAGG AAACCCCCAG CCCCCCACGT CTCGTTCTGG ACCAGGAACC CCCTCCCCAA CAACCGCGCA 001280
001281 GCAAGTGGCG ACTCTGGGAG CTGAACTGGA GTGGAGCTCG AAGTGGCTGG GGCGGGCAAA GACTCCCGCT TCACTCTGGG 001360
001361 ACACAACTGG GACGGCGCTT CAACCTCTGC CTGCAGGCGT GCTTCTCGCG CGCACCAGCA AGCTCTCTAT CCACCTCGCC 001440
001441 TGGGCCTTTG CAGCGCCCTG CCGCCCAGGC TCCAGCGCCT CTACTACCCT AGCCCCTTCT CAACACGCGG CTCTGCCTTC 001520
001521 TTCCCCAGTA CCACTGCACT GCCGAAAATA AGCCCGGAGA CTAACGCACC TTGTAGGGAA GAGAAGGACA TCTGTATCTC 001600
001601 CAAGCTTATC CAAGCAAAGG CCTCCAGAGT CCCTCCCATG GCCCGAAACA CCTCCCTCTG ACCGAAGAGC GTCCTTTCTT 001680
001681 TCCGCCGCCT CCTGGACTCA TCCTAAATAG GGCAGACCCG GGCTAAACCA GTGATTTTTT TTTCCATGAA TACGAAGAAC 001760
001761 CCCGATTGCA CTTTG
