LINC00514
LINC00514 is a top candidate implicated in the development of neuroendocrine prostate cancer (NEPC) and is also a strong candidate as predictive biomarker for metastatic disease.
Contents
Annotated Information
Name
LINC00514: long intergenic non-protein coding RNA 514(HGNC nomenclature).
Function
LINC00514 is predicted to bind to TADA3, potentially causing a reduction of its activity. This is intriguing because TADA3 is involved in the stabilization and activation of p53, and this putative interaction (LINC00514: TADA3) could be an alternative mechanism for loss of p53 activity, already known to be frequently lost in NEPC [1].
Regulation
KDM4B and TADA3 are mRNAs that are predicted to hybridize and form joint structures independently with SSTR5-AS1 and LINC00514, respectively [1].
Diseases
- Neuroendocrine prostate cancer (NEPC) [1]
Expression
The expression of two NEtD/NEPC lncRNA transcripts (SSTR5-AS1 and LINC00514) was able to separate patients more likely to develop metastatic disease from those that did not [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | NA | NA |
Labs working on this lncRNA
- Vancouver Prostate Centre & Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. [1]
- GenomeDx Biosciences Inc., Vancouver, BC, Canada. [1]
- Department of Computer Science, Simon Fraser University, Burnaby, BC, Canada. [1]
- Department of Experimental Therapeutics, BC Cancer Agency, Vancouver, BC, Canada. [1]
- Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA. [1]
- Department of Urology, Mayo Clinic College of Medicine, Rochester, MN, USA. [1]
- Department of Pathology and Laboratory Medicine, Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY, USA. [1]
- Department of Computer Science, Indiana University, Bloomington, IN, USA. [1]
- Department of Medicine, Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY, USA. [1]
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Ramnarine VR, Alshalalfa M, Mo F, Nabavi N, Erho N, Takhar M, Shukin R, Brahmbhatt S, Gawronski A, Kobelev M, Nouri M. The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications[J]. GigaScience. 2018, 7(6).
Sequence
>gi|283875|ref|NR_033861.1| Homo sapiens long intergenic non-protein coding RNA 514 (LINC00514), long non-coding RNA
000001 GATGCATCTG AGCTTCAGGA GAGAAAGATG GGGGGCAGAG GTGGTGAGAA GAAGAGGAGG AGATTTCCAT GAAGGGAGAG 000080
000081 GAGCCCAGTA CTGAGAATGG ATGGGAGAGG AGAGGAAGAG GGTGGAGTGG GCTCTGCCCC ACAGTCCCCC AGAGCCCTGG 000160
000161 CTCAGACACC TTCCTCCAGG CCCAGGGGCC CTCTAGCCTC CACTGCCCTA GCCCCAGACT GCTCACCTCC TCTGCCCTCT 000240
000241 ACCCTCCTGT GACAGCAGGG AAACTGAGAC CTGGAAAGGG AGGTGGCATC CAGATTTGGG CCCCTTTGTC CCCTTGTAAG 000320
000321 TTCCCCTGCT TCCCCCTGAA CCCCACAGGC TTAGGGAGCC CAAATGGCTA CAGATCTGGT AAAGCTGGTG GCGGGGTGCT 000400
000401 TGGGGAGGGT GGCACACCGG CTCCCAGCTG CTCCAGCACC CCGGGCTCAA CATCTCACTT CTCCCACAGT CTATGGCCCC 000480
000481 CACAGTGGCC TGGGAGCAGG ATTCGTGGTC AGGCATGGGC TGGGAACCCA GCCAGGTGAG AGCCGTGGGG TCCCCTCCTT 000560
000561 CCCTCCCTCC CAGGCCTCAG ACGGAAGAGG CAGGATTGGA GAGATTGTTG GGGGGAGGCG CAGAGAGCCT CTCAGGTTTG 000640
000641 CTGGTGTCTG GCTTAGTCCA AGGGGGGGTT CAAGGGTCTT GTACCCCCAC CTCAGCTGGG ACCCCAAACC TCCTCAGCTC 000720
000721 ACCTCTCTCT CTCCCACGAG CCCTTCCACT AAGAATGGCT ATGGAGCAGG TAGAGATGGG AGTGGGGGAG CTGGAAGCCA 000800
000801 GGATTCTAGG GGTATCCCTG GGATGGGGAT TCCTGAGCCC CTCATCTGAT CCCCCTCTCT TTCCCAGACA CTGAAGGGGG 000880
000881 CATGAAACCC CAAAACCTAG GTGAGGCTCG CCCAGCCCCT GCCTGCCTCC CTCCTCCTGA CTCCCTCCTG CCTTCTCGCC 000960
000961 CCAGGGTTCA GGACCTTCGC AGGTGCTGCA GCCCAGCCAG GATATGGAAA CGGGCTGGGA GCAGCGGCCT TCCCAGTGGC 001040
001041 CGGAGCCCAG TCAGGATTGG GGAGCAGAAG TGGTTTGGGC GCTGGCACTC TTCCAGGGGC AGGAACCCCA CCAGGATACA 001120
001121 ACAATGGAAA CGGACCGGGA ACCCAGCCAG GTCGGGGCCG AAGGGGCTGG GGTGGCTGGG GGAGAGGTCA GGGGCCCAGG 001200
001201 GCCACACTCT GGGTCCCAAC AGATGGGCTC TTGGGGGTTC ATTCATTCAC CCAATCTCCC CTGAGCACCC GTCCCAAGCC 001280
001281 AGGCCTCGGC TGGCCATGGA GGACACCCAA GCTGGTCAAG GGTGGCCACG GTCTGGACTC CCGGGCCAAG AACCAAATCC 001360
001361 AACTTTGACT GCAGTCAGGC CTGGGAGGGA GTTCACACAA GACAGAAAGG CAGAGGGCAG GGGTCACGCG AGACAGAAAG 001440
001441 GGAGAGGGCA GGGCTCCAGG CCCCAGCTCA TCCCCACTGC ACCACCTTCC ACACTCCTGT GTCTGCCCTC AAACAGGTCC 001520
001521 TGCCGCTCAA AATGGCTTTG GACCAGGTAA AGAGGGTGGG GACGGAAGCG GGGAGCCTGG GGCTGAGATT CTGGGCACAG 001600
001601 GCCCAGAGGA AAGGATCCCT CACCCTCTCA TCTTCCCCCC AGGCTTTGGA GGGGGTGGAA AACCCCAGAA GCCAGGTGAG 001680
001681 CCACTCCCTG TCCCTGTCTC CCTGCCCATT TCCTATGCAT CTGCCGCTGC TTCCCTAGAG TCCCTGATCT CCCCATTCTC 001760
001761 TTTGGCTCTG TCCCCTGGGA TTTGGGAATA GGAATGGGTG GGGAGTCGGG GCCTTCCTGG GAGCTGGAAC CCAGGCAGGT 001840
001841 AAGGCCCTGG AGTTCTGGGA GCATGGAGGT CTTAGGGGTT GGGGGTTACT GATGTAGGGG CCTGGCCCTG GTCCTGAGCA 001920
001921 GAGAGGAAGG GATGGGTGGA CTCACAGGAA GTCCTTCCCC TTCTCTTCCC AGGCCTGGGA GGGGGACTAA AGGCTCAGAG 002000
002001 AGCAGGCGAG CCCCAATCTC TAGCCTCCCA ACTTGGTCTC ACACAACAAA CCTCATTCGA CAAACCAATC CAGGCCTGGA 002080
002081 GCAGTGGCTA ACACCTGTAA TCCCAACAGT TCGGGAGGCA GAGTTAGGTG GATCAATTGA GCCCAGGAGT TCAAGACCAG 002160
002161 CCTGGGCAAC ATTCCCAAGC TGGTCTTGAA ATCTTGGGCT CAAGCAATCC ATCTACAAAA AAAAAAAACC TAGCCAGTTG 002240
002241 TGGTGGCACG TGCCTGTAGT CCCAGCTACT CTGGAGGCTG AGAGGTGAGG ATCACTTGAG CCCAGGAAGT CGAGGTAGTA 002320
002321 GTGAGTGGAG ATCTTGCCAC TGTACTCCAG CCTGGGTGAC AGAGAGAGAT CCTGTTTAAA AAACAGACAG GCCGGGCTCA 002400
002401 GTGGCTCACG CCTGTAATCC CAGCACTTTG GGAGGCTGAG GCGGGTGGAT CACAAGGTCA GGAGATCAAG ACCATCCCGG 002480
002481 CTAACACAGT GAAACGCCGT CTCTACTGAA AATACAAAAA AATCAGTCGG GCGTGGTAGT GGGCACCTGT AATCCCAGCT 002560
002561 ACTCGGGAGG CTGAGGCAGG AGACTGGCGT GAACCCAGGA GGCGGAGCTT GCAGTGAGCC GATCGTGCCA CTGCACTCCA 002640
002641 GCCTGGGTGA CAAAGCAAGA CTCCGTCTCA AAAACAAACA AACAAACAAA CAACAACCAA AGTAATCCGT GGACCATGCC 002720
002721 TGTTCTGAGC CAACCAGGTG CTGGGGACAG GCCCTCCCCA ACCAGGGCCA CGCTGGGGCA TACAGTATGG GCTGAGGCTG 002800
002801 CCCCAGAGCT GGGCTCTGGG AGTTCTTAGG AGGCAGTGGA GGCCAGGGAG GAGAGAGTGG CCCAACCCTC TGAGAAACTG 002880
002881 AACCAAAAGG AGAGTTTTGA ACAAAGAAGG TACAGGCTCC AGCAAGATCT CAGACCTGGC CAGGCGCAGT GGCTCACGCC 002960
002961 TGTAATCCCA GCACTTTGGG AGGCCTAGGC GGGCGGATCA CTTGAGGTCA GGAGTTCAAA ACCAGCCTGG CCAACATGGT 003040
003041 GAAACTCCGT CTCTACTAAA AATGCTAAAA ATTAGCCAGG CGTGGTGGCG GGCACCTGTA ATCCCAGCTC CTCAGGAGAC 003120
003121 TGAGGCAGGA GAATTGCTTG AACCCGGGAG GCGGAGGTTG CAGTGAACCA AGATCACGCC ATTGCTCTCC AGCCTGGGCA 003200
003201 ACAAGAGCGA GACTCCATCT C
000081 GAGCCCAGTA CTGAGAATGG ATGGGAGAGG AGAGGAAGAG GGTGGAGTGG GCTCTGCCCC ACAGTCCCCC AGAGCCCTGG 000160
000161 CTCAGACACC TTCCTCCAGG CCCAGGGGCC CTCTAGCCTC CACTGCCCTA GCCCCAGACT GCTCACCTCC TCTGCCCTCT 000240
000241 ACCCTCCTGT GACAGCAGGG AAACTGAGAC CTGGAAAGGG AGGTGGCATC CAGATTTGGG CCCCTTTGTC CCCTTGTAAG 000320
000321 TTCCCCTGCT TCCCCCTGAA CCCCACAGGC TTAGGGAGCC CAAATGGCTA CAGATCTGGT AAAGCTGGTG GCGGGGTGCT 000400
000401 TGGGGAGGGT GGCACACCGG CTCCCAGCTG CTCCAGCACC CCGGGCTCAA CATCTCACTT CTCCCACAGT CTATGGCCCC 000480
000481 CACAGTGGCC TGGGAGCAGG ATTCGTGGTC AGGCATGGGC TGGGAACCCA GCCAGGTGAG AGCCGTGGGG TCCCCTCCTT 000560
000561 CCCTCCCTCC CAGGCCTCAG ACGGAAGAGG CAGGATTGGA GAGATTGTTG GGGGGAGGCG CAGAGAGCCT CTCAGGTTTG 000640
000641 CTGGTGTCTG GCTTAGTCCA AGGGGGGGTT CAAGGGTCTT GTACCCCCAC CTCAGCTGGG ACCCCAAACC TCCTCAGCTC 000720
000721 ACCTCTCTCT CTCCCACGAG CCCTTCCACT AAGAATGGCT ATGGAGCAGG TAGAGATGGG AGTGGGGGAG CTGGAAGCCA 000800
000801 GGATTCTAGG GGTATCCCTG GGATGGGGAT TCCTGAGCCC CTCATCTGAT CCCCCTCTCT TTCCCAGACA CTGAAGGGGG 000880
000881 CATGAAACCC CAAAACCTAG GTGAGGCTCG CCCAGCCCCT GCCTGCCTCC CTCCTCCTGA CTCCCTCCTG CCTTCTCGCC 000960
000961 CCAGGGTTCA GGACCTTCGC AGGTGCTGCA GCCCAGCCAG GATATGGAAA CGGGCTGGGA GCAGCGGCCT TCCCAGTGGC 001040
001041 CGGAGCCCAG TCAGGATTGG GGAGCAGAAG TGGTTTGGGC GCTGGCACTC TTCCAGGGGC AGGAACCCCA CCAGGATACA 001120
001121 ACAATGGAAA CGGACCGGGA ACCCAGCCAG GTCGGGGCCG AAGGGGCTGG GGTGGCTGGG GGAGAGGTCA GGGGCCCAGG 001200
001201 GCCACACTCT GGGTCCCAAC AGATGGGCTC TTGGGGGTTC ATTCATTCAC CCAATCTCCC CTGAGCACCC GTCCCAAGCC 001280
001281 AGGCCTCGGC TGGCCATGGA GGACACCCAA GCTGGTCAAG GGTGGCCACG GTCTGGACTC CCGGGCCAAG AACCAAATCC 001360
001361 AACTTTGACT GCAGTCAGGC CTGGGAGGGA GTTCACACAA GACAGAAAGG CAGAGGGCAG GGGTCACGCG AGACAGAAAG 001440
001441 GGAGAGGGCA GGGCTCCAGG CCCCAGCTCA TCCCCACTGC ACCACCTTCC ACACTCCTGT GTCTGCCCTC AAACAGGTCC 001520
001521 TGCCGCTCAA AATGGCTTTG GACCAGGTAA AGAGGGTGGG GACGGAAGCG GGGAGCCTGG GGCTGAGATT CTGGGCACAG 001600
001601 GCCCAGAGGA AAGGATCCCT CACCCTCTCA TCTTCCCCCC AGGCTTTGGA GGGGGTGGAA AACCCCAGAA GCCAGGTGAG 001680
001681 CCACTCCCTG TCCCTGTCTC CCTGCCCATT TCCTATGCAT CTGCCGCTGC TTCCCTAGAG TCCCTGATCT CCCCATTCTC 001760
001761 TTTGGCTCTG TCCCCTGGGA TTTGGGAATA GGAATGGGTG GGGAGTCGGG GCCTTCCTGG GAGCTGGAAC CCAGGCAGGT 001840
001841 AAGGCCCTGG AGTTCTGGGA GCATGGAGGT CTTAGGGGTT GGGGGTTACT GATGTAGGGG CCTGGCCCTG GTCCTGAGCA 001920
001921 GAGAGGAAGG GATGGGTGGA CTCACAGGAA GTCCTTCCCC TTCTCTTCCC AGGCCTGGGA GGGGGACTAA AGGCTCAGAG 002000
002001 AGCAGGCGAG CCCCAATCTC TAGCCTCCCA ACTTGGTCTC ACACAACAAA CCTCATTCGA CAAACCAATC CAGGCCTGGA 002080
002081 GCAGTGGCTA ACACCTGTAA TCCCAACAGT TCGGGAGGCA GAGTTAGGTG GATCAATTGA GCCCAGGAGT TCAAGACCAG 002160
002161 CCTGGGCAAC ATTCCCAAGC TGGTCTTGAA ATCTTGGGCT CAAGCAATCC ATCTACAAAA AAAAAAAACC TAGCCAGTTG 002240
002241 TGGTGGCACG TGCCTGTAGT CCCAGCTACT CTGGAGGCTG AGAGGTGAGG ATCACTTGAG CCCAGGAAGT CGAGGTAGTA 002320
002321 GTGAGTGGAG ATCTTGCCAC TGTACTCCAG CCTGGGTGAC AGAGAGAGAT CCTGTTTAAA AAACAGACAG GCCGGGCTCA 002400
002401 GTGGCTCACG CCTGTAATCC CAGCACTTTG GGAGGCTGAG GCGGGTGGAT CACAAGGTCA GGAGATCAAG ACCATCCCGG 002480
002481 CTAACACAGT GAAACGCCGT CTCTACTGAA AATACAAAAA AATCAGTCGG GCGTGGTAGT GGGCACCTGT AATCCCAGCT 002560
002561 ACTCGGGAGG CTGAGGCAGG AGACTGGCGT GAACCCAGGA GGCGGAGCTT GCAGTGAGCC GATCGTGCCA CTGCACTCCA 002640
002641 GCCTGGGTGA CAAAGCAAGA CTCCGTCTCA AAAACAAACA AACAAACAAA CAACAACCAA AGTAATCCGT GGACCATGCC 002720
002721 TGTTCTGAGC CAACCAGGTG CTGGGGACAG GCCCTCCCCA ACCAGGGCCA CGCTGGGGCA TACAGTATGG GCTGAGGCTG 002800
002801 CCCCAGAGCT GGGCTCTGGG AGTTCTTAGG AGGCAGTGGA GGCCAGGGAG GAGAGAGTGG CCCAACCCTC TGAGAAACTG 002880
002881 AACCAAAAGG AGAGTTTTGA ACAAAGAAGG TACAGGCTCC AGCAAGATCT CAGACCTGGC CAGGCGCAGT GGCTCACGCC 002960
002961 TGTAATCCCA GCACTTTGGG AGGCCTAGGC GGGCGGATCA CTTGAGGTCA GGAGTTCAAA ACCAGCCTGG CCAACATGGT 003040
003041 GAAACTCCGT CTCTACTAAA AATGCTAAAA ATTAGCCAGG CGTGGTGGCG GGCACCTGTA ATCCCAGCTC CTCAGGAGAC 003120
003121 TGAGGCAGGA GAATTGCTTG AACCCGGGAG GCGGAGGTTG CAGTGAACCA AGATCACGCC ATTGCTCTCC AGCCTGGGCA 003200
003201 ACAAGAGCGA GACTCCATCT C
