GARS-DT

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GARS-DT, A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction

Annotated Information

Approved Symbol

GARS-DT

Approved Name

GARS-DT: GARS divergent transcript, AC005154.6, AC005154.1

Characteristics

GARS-DT is located downstream of the CRHR2 gene between the genes GGCT (gamma-glutamylcyclotransferase) and GARS (glycyl-tRNA synthetase). [1] GARS-DT has numerous alternative splice variants and its first exon overlaps the GARS gene first exon in the reverse orientation. The region overlapping CRHR2, GARS, AC005154.6 and GGCT displays strong LD and several SNPs in this region including in CRHR2 are associated with AC005154.6 expression, but they are not in strong LD with rs255105. [1] Only a part of GARS-DT is evolutionally conserved among primates, and only small regions are conserved in rodents. There are several regions enriched with histone modifications. [1]

Function

GARS-DT LncRNAs that are encoded between genes AC005154.6, are known as long intergenic non-coding RNAs (lincRNAs). [1] GARS-DT play a role in a wide range of functions including adaptive behavior and neurological diseases and are potential new biomarkers and drug targets for stress-related disorders. [1] The majority of GARS-DT lncRNAs show tissue- and temporal-specific expression in the CNS. [1]

Regulation

NA

Diseases

  • Neurological diseases (heroin addiction) [1]

Expression

RNA-Seq data (GTEx) indicate expression of GARS-DT in various tissues with relatively higher expression in the pituitary. [1]

Labs working on this lncRNA

  • The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, United States of America
  • Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America
  • NYU School of Medicine, New York, New York, United States of America
  • Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Las Vegas, Nevada, United States of America

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Levran O, da Rosa JC, Randesi M, Rotrosen J, Adelson M & Kreek MJ. A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction[J]. Plos One. 2018, 13(6).

Sequence

>gi|401320|ref|NR_038889.1|Homo sapiens GARS divergent transcript (GARS-DT), long non-coding RNA

000001 CAAACTGCCA CCGGAACTGC TTTAAAAATG TTTGGTTCAC AGCCTTCACT GGATTACCTA TTGGAGCAAA CAAAGTGTAA 000080
000081 CCATGTAAAA CCTGTGAGCT TGTATTGATA TCTCATGGCT AGAGTTCCAA GCGAATGGGT CTCATGAGAT CTGATGGTTT 000160
000161 TGAAAATGGG AGTTGCCCTG CACAAGCTCT CCTTTTGCCT GCTGCCATCC ACATAAGATG TGATTTGCTC TTCCTTGCCT 000240
000241 TCCACCATGA TTGTGAGGCC TTCCCAGCAT GTGGAAATTT GCAGGAATTT AGCCAATTCA GAGGTCTTGT TCTCCATAAT 000320
000321 TTGGAATTTT CCTTCGGATT TGATCAAGTT GGATAGAGTT GGTCAAACCC AATGGGAAAA AGATGAAAAC AACAAGAAAC 000400
000401 AGAAACAAAC AGCAACAACA ACAACAACAA AAACAATGCA TTTAATTAAA TGAAGATGAG CTCATGCTGG AGTAGGGTGG 000480
000481 ACTCTGAACC CAGTGGGACA AGCGTCCTTA TTAAGAAGAG GGAAATCTGG ACACACACAG AGCAGAGACC GCCGTGTGAA 000560
000561 GATGGAGGCA GAGATCGGAG AGATGCTGCC ACACGCCACA AATGCCTGGG GCTCCCAGAA ACTACACGGA GCCTCCCCCA 000640
000641 GCGGCTTCAG CAGGAGCATG GCTCGGCCAA CACTTTGATC TTGGTCTTCC AGCCTCCAGA ACGTTTTCCT AAAATTCCCT 000720
000721 TTTCCACTGG TGTGTGGTGC AAGATGAGGC ACATTTTCCA TGGATGGTGA ACAGAGGGAG GAGCCTTTTG ATCACAACCA 000800
000801 GGTCACCCCA CTTCTAAGCC ACTGTGCCTC CAGCCCCACA AGACTAAGGA GAGAGAGCGC AGCGTGGTGG AGAGTGAGCT 000880
000881 GTGCTGGGAC CATTGTTTCC GTAACCTCGT TTTCTGTGTC CAGCTGACAC ACCTTCAAAG TGGCATCAGG TCCTAAACTG 000960
000961 TAGCTTGCAA TGTGCCTGTT TCCAGAAACC AAGGTGAAAG TGCTTTTAGA CAGTGTTCCC ATGCAAGAGT CCCTTCCCAG 001040
001041 CTTTTTTCTG GAAATGCATG TTTCTCTGAA CTCTGAGTCC CAAGAAAAAT CACTTGAGAC ACCAAGAAAA TGGGGGAAGT 001120
001121 GCTAAAATTG TGTGGGAATT CAAGCTTAAC AATAAACATC AAGACATTTT TGATAAAAAT GAATCCACTG ACATCGGGGA 001200
001201 GGAGCAAGAG AACAGCACGC TGACACTGGG TCAGAGGCTA AGACCGACAT TTCTGGGAAC CACTCCCGGA AGGGCACAGA 001280
001281 GGAGACGCTT TCAGCCTCTC ATCAGCCAGC CTGGCCTGTA GCTGCTGCAC GTTATGAGTG TGTTCCTGGC ATGACTGCTT 001360
001361 CTAACAGCGA CCATTTCATT AAGTTTTTAA GTGCCTGGTA ATTGCTTGGT TATGACCGGT GTCTGCTCCA TGGCAGCCTC 001440
001441 TTCCTGAAGA AATGCTGAGG CAGTGTCACG CTGGTGTCTG TCCTCCTTAC AGAATGCCTG AACAGTTCCA TTGACTCAAA 001520
001521 GTGAAGATCA AAAGAACCAA ATGACAGCAA TAGCCAAGTG TAATCATCAG TAACCCTGTG TTCTATCCAC AGGTAAAAAA 001600
001601 CAATCATCCT CTTCATTATG GGTTTCAATT TTAAATGTAA TACATTTTTA GAAATGCCTA TTTCCTTTTA TAATCTCTTT 001680
001681 ATATAATCTA GGTTATTCTG GCTCTTAGGT CTTCATTTAG CTACTGAAAA GATTTGATCT CAAATCAATG ATCTAACCAC 001760
001761 CCATGACCAT CTCCCACCTC TCTCCCCGTA CACCCCCCAG CATGAATTCT GGGAACTCAG GTAAAATGCT TTCTGGAAAC 001840
001841 CTGCCTGTAT TAGTCTGTTG TCAAGCTGCT AATAAACACA TACCCGAAAC TGGGTAGTTT ATAAAGGAAA GAGGTTTCCT 001920
001921 TTATAGTTCC ACATGGCTTG GGAGGCCTCA CAATCATGGT GGAAGGCGAA TGAGAAGCAA AGTCACATCT TGCATGGCAG 002000
002001 CAGGGAAGAG AGAGTTTGTG TAGGGGAACA CCCCTTTAAA AAACCATCAG ATCTTGTGAC ACTCATTCAC TGTCACGAGA 002080
002081 ACAGCACGGG AAAGACCCGC CCCCATGATT CAATTACCTC CCATGACACA AGGGAAGTAT AGGAGCTACA ATTCACAATG 002160
002161 AGATCTGGGT GGGGACACAG ACAAACCATG TCACCGCCTA AAACCAACTC AATAGTCTAA GGAATTTGAC TGGGGAGAAT 002240
002241 CTGGAGAGGA TTTAATTAAT TTGGCAAAAG GATTAGCAAT TGAATCTAAG TGAGAAAAGA GAATTCTTGG AGGAAAAAAA 002320
002321 GATGTTTAGT TACACTGAGA AATTAAAACC TGAAGTAATT GCCTTTGAGA TTTTTTTCAG GAAATGAGTA TTGATTGCCT 002400
002401 ACTGTGTGTC AAATTATGTG TTTCATGTCA AAGACTCCAA AGTAGATAAG ATATAGGCCC AGCCTTGGGG AGCTCATTGA 002480
002481 GTCACAGAGA AAGTTTGAAT GTTTCAGAGG AATCATCAAG AACAGGGGAT CAGCAATCTA TTATATTTTA ATTGCGTCTT 002560
002561 TTCATGATTA TAAAAGCAAT GCATGCGTGC TGAAGAGAAT TTGGAAAAAC AAAGAAGAAA TTAAAAATCG TCTCTGATCC 002640
002641 TGCCACCAGA AATAACCACT GTTAGCAATT GTATCACTTC TGTAGGTCTA CATGGTTATC ATAATAAGCT CTAGTATTGA 002720
002721 TTACATGCAT CTCATGTACC AGAGATTATG CTAGACTCTC ATTTAATCTG TACATTAGCC CTATGAAGTA GGGACCATCA 002800
002801 TTCTCCTCAT TTTACAGATG AGGAAACAGA GGCTTGGAGA GGTTACTCTG CCTAAAGTCT CATAGCTAGC GAGTGGCAGA 002880
002881 GATTGGACTC ACCCAAGCTT TGTCTTATTC TCAAGCTCTC AACCAACCCG GTGGTGAGAA GAGCCAGCAG CAAAGCCTGT 002960
002961 CATCTTTGTC TTCTTTTTTT TTCTAACCTC AAATCAGGGA GAAAATGCCC TTTGTCATTA GAAGGGCAAG GCAATTCTGA 003040
003041 AGACAGCCCA GTTGGCTTGT CTCCGATTTG GCTTTCAGGG GCCTGTCTGA TACCTATGGA GAGACGAGGG CTGAACAAGC 003120
003121 TGTACTCTCA AAACAAAACA AAGCAAAACA AAACTTTAGT CTCTTTAGGG ACTCTCTGAT AGTAATGCAG AGGGAGAAAG 003200
003201 GCTTTCTTTG TCTCACTGGG AGGAAGGTTC CCTACGGAAA TTGAAGGCAG TGCCTGTTGA CATAGCGCTG CCACCTGGTG 003280
003281 GAAATAATGG TGTAGGACAT CATGTCCAGC ACCACTAGCG CTGAGACACT CCCTGGGAAG AGAAATGTTT GGAGAGAAAT 003360
003361 TTGCAAGAAG TTGGAAGTCT CGCAGTAGCA GGTAGGAACA AGAATTATAA CTGCTACTGT GACCCCCTAA GGCTCCTCAC 003440
003441 ATCCTCTTAA GGCTTGGAGA AACTCACACT ATGTATATTT TCCTGTATTT TTGAAAAATG TTTTCCTTTA TGCTTTGTTG 003520
003521 TAATGAAATT ACCTCTGATG GTCACATACC TTAAATATTT AGTATATATA TGAATACTAA ATGTCCATTT TCAGGAGTTA 003600
003601 GTTTACCTGC ATCTAAAATC AGGAATAGGT CACAGAGTAA CTGAGCAAAA AGTGCTGTTA GGTTTGTGCA TTTCACCCTT 003680
003681 TGCCTGGGAT GAGAGGACCT CAATCATCTT GGTACTAATG ACAGGAAAAG TGCCCTCCTA TCCATGTGTA TCGGCTACGT 003760
003761 GACTCAAGTC TCCTTATTTC CTTTTCTAGC ATAACAAGGG GTTGTTACTG TTGTTTTACA TCTGTGTTAA TGAGATAAAT 003840
003841 AAGTTTAAAA TAAAAAGATG TGTACCAGGC A
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