LINC02595
LINC02595 is involved in distant metastasis and is also associated with poor prognosis in patients with colorectal cancer (CRC).
Contents
Annotated Information
Name
LINC02595: long intergenic non-protein coding RNA 2595 (HGNC nomenclature). Synonym: AK098783 [1].
Characteristics
Human LINC02595 gene is located in the chromosome Xp11 gene desert between HDAC6 (Histone deacetylase 6), WDR45 (WD repeat domain 45) [1].
Function
Study confirms that LINC02595 is an independent prognostic factor in CRC and correlated with metastasis by detecting RNA level in clinical specimens, however it cannot be confirmed that LINC02595 may promote CRC cell invasion and metastasis in vitro [1].
Regulation
NA
Diseases
- Colorectal cancer (CRC) [1]
Expression
LINC02595 expression level is frequently higher in cancerous tissues than corresponding noncancerous tissue. Higher LINC02595 expression is significantly correlated with shortened overall survival and distant metastasis [1]. Data shows that patients with high expression of LINC02595 have significantly shorter overall survival time and metastasis free survival time than patients with low LINC02595 expression [1]. It was also found that distant metastasis was the clinical factor correlated with LINC02595 overexpression in CRC [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-GAAAAACCACAGGCCCACTA- 3' | 5'-GCGTCTTCTGCCCTTCATTA- 3'[1] |
Labs working on this lncRNA
- Department of Oncology, The Affiliated Hospital of Jiangnan University, Jiangsu. [1]
- Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing. [1]
- State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China. [1]
References
Sequence
>gi|401585|ref|NR_125365.1| Homo sapiens long intergenic non-protein coding RNA 2595 (LINC02595), long non-coding RNA
000081 AGCTGGAGAC TGCAACAGCG GCGGGTGCAC CGGCAGCAGC GACGACCCTG CGCGCAGGTG GCAGTGTAGA AGCCAGACCG 000160
000161 GGAGCTTCCA GAAGTGGTTT CTGAAAGAGT CAAATGTACA TGAGTAAGCA AGCACAGGAA TCTGAAAAAC CACAGGCCCA 000240
000241 CTAATTTGCC TGCTTGACTA AAATAAGGAC GAGTTATGTG CTGATGAGAG ACATGTTTGT AATGTTATTC GTTGTGACAC 000320
000321 AGTTCAAAAG AATTTGCCTT TGATTCTCAC TAAAATGTAA AGTTTTGCAT ATTAA
