GPRACR

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GPRACR,drives the self-renewal of liver tumor initiating cells and liver tumorigenesis through GPR107-dependent manner.

Annotated Information

Approved Symbol

GPRACR

Approved Name

GPRACR: GPR107 adjacent cis regulating lncRNA, LncGPR107

Characteristics

GPRACR belongs to the class on long non-coding RNAs residing at chromosome 9q34.11 [1].

Function

GPRACR drives the self-renewal of liver TICs through GPR107[1]. Moreover, GPRACR recruites SRCAP complex to GPR107 promoter to drive its transcriptional activation [1]. GPRACR depletion inhibited the binding of SRCAP complex and GPR107 promoter and subsequent GPR107 expression [1]. GPRACR-SRCAP-GPR107 can be targeted for liver TIC elimination [1].

Regulation

NA

Diseases

  • Liver cancer [1]

Expression

GPRACR was the most highly expressed GPCR in liver cancer and liver TICs [1].

Labs working on this lncRNA

  • Department of general surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Department of Abdominal Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
  • Department of Abdominal Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6

Sequence

>gi|401554|ref|NR_135124.1|Homo sapiens GPR107 adjacent cis regulating lncRNA (GPRACR), long non-coding RNA

000001 ACACAGCTGA AGGACCTGGA AAACCACAGG AAGTTGAATT TGGTCGACGG AGCATATGAG GAGTGGTGGC GGGCATCTCA 000080
000081 AGAGGGGAAG ACTCTCCCAC TGTGTTATAA GCTGCTAAAG TCAAGGAAGA CAATAGTCAA GCCCCCAGAG GTTGCGAGTC 000160
000161 ACTCTAGCCA GACCGTGGCA GGGTGGAAAC CAGCCCACAG TGCGCCGGGG CGTCTGGAAG ATGAAGCAGC GGAACTCAGA 000240
000241 GAGCTCTGAA GGGGGACGGG GGCCTGCAGC TGTTTTTTTT GTTAGCTGCT TTTTGTTCAT GGGAAAACTT GAACAAGCTT 000320
000321 GATTGCTTCA TGGAAGGAGC CAGGTGACAT GGAAAGGGGA AAGATGCAGA GTAAGGGGAC CGAGGGACAG CGAGATGGCT 000400
000401 GCAAAGGTGG AGGGAAGAAG TGAGTGGGAA CGGAGGAGAC GTGGTGCTGC CGCTCAGCTG TGCCCCATGG CTTTGCCCCG 000480
000481 TGGCTTGCTC CCCTCCTCAG TACTGTTCTC TCCCGTGTGG CACAGCCAGG CTTACTCATC ATTTCATCTG CAGCCCTGCC 000560
000561 CATACCAGCG TGTGCTGAAC GATGTTGAAC CTTAGGCGAC GGAGGCCGAC TGGAACCAGG GCTCTGAGTG ACAGAGACGC 000640
000641 AGTTATGTCT AAGGACATAC GCTAGAATGG CTGATGCAGG GCGCAAGCTC GATTCCTGCA GATGTGTGTT AATGAGCAGC 000720
000721 TCCCTCATTT TTGCAAAGGT CAGCATTCCT TTGGCAAACT GGGAAGGAGC AGTTTAAGGT GCAGCTCCCA AGTGGGTCAC 000800
000801 ACCGACCCCC CAACATCCAG TTCCCAACTG CTGAGCGTGC TTCTCTTCGT GGGAGTGGGC GGGCCAGTGC CGAGGGGCTC 000880
000881 AGGACGGATT CTCAGAAACG CCCCACCATG CAGGTGGCTT ACGGGAGGGC AAAGCCAATG CCAGCCTCCA GGAAGTCTGC 000960
000961 GCTTTCTTTC CTTAGGCTGC CAATCAGAGT GGACCAGCTG GAGATGACCA ATCACATGAC AAGACTCCTG CACAAAGGGA 001040
001041 AGAAATGAGA TGCTGCAGCT GAGGAGGGCG GCCAACCTGG GAGGCATCTG GCTCCCCTGA CAATGCCTGC CGATCGCCAA 001120
001121 GCTGGCTTCC AGACCTCCTG GGACAGAACT GTTCCTCCCA GGACGCTGGT GTAGGTTCAA GTCCAGTTGA TATTTACTAA 001200
001201 GCAACTGCAA TGCCCAGGCC TGTTCCAGTG CTGCAGAGAG TAAGTGCTTA TGGGTGCTTA TATTCAGAGT AAGTCAATAC 001280
001281 ACCAGCTTCG TATGACCTGC GTCTTCGGGG CCAGCAGGGC AGGTTGGTCT CCTCAGCCTC ACACTGGAGC TCCTGGCTGG 001360
001361 CTGGTGTCTG CGGTCAGGAC CCTAGTGATG GGAGGCTCAG CAAACAGAGG AGGCAGAGGG GCTGTTCTGA AATGACCTTG 001440
001441 AAACGACCTA TCACCCTCAG GGGTGGTCTT ACTGGATGAA GTCCAGCCCG CCATAGGCAC TGAAGGGCTC TCATTTGCTG 001520
001521 AGCCCTTGCT TTGCGCCAGG CGGCTCTTCC TCTGCCGACA CTGATCAAAG GAGGGTGCGA GGCTCAGCTA CTGAAGCCGG 001600
001601 GGTCAGACTT GTGGGCGTGG GCTTTTCTAA TGCCAAACCC ACGGGCGCCA AGGCTTCTCA AGCTCATCCT GTCAGCCCCT 001680
001681 GAATTTCTAA CTGGCAAAGC TCCACGCTAG CGGTGGGGGA AGAAGGAGCC AGAGAGACCT GAACTGCAAG GGGACCCCAT 001760
001761 GTGGGATGGT TCAGGGGAGC AGCAGGACAG CCAGGCCCCT GCCAGCACCT GCCTGCGGTC TCTCACCTGG TCCCGACTGC 001840
001841 AATGCCTCCT GGCAGGACAG AGCCGCCGAC TTCTGTCCCG TAAGAGCTGT GTGCAAGGTG GGCCCTTGTC CGTGTTGCCA 001920
001921 GCTGAAGACT GACCCAAGAC TCGGGAAGAG AACTGGGTTG GATCTGTTCT CAGTGTGGTC CAGATCTGCC ATGTTGGCAC 002000
002001 CAGCTGGGAG TGTGTTAGCA ATGCCGACTC TCAGGCCCCC CAGGAACTCT GTCGGGGATT CGGGTGCTTG CTGTTTGAGG 002080
002081 ACCACTGGAT TAGATATCAG CAAGGTCCTT CCTGAGTCTT TTCTCAGCTG TCCCCTTCTC GAGTTGCCTT GGCATCTCTC 002160
002161 ATCCTGGGTT CTGAATCCTG GACTC