ADPGK-AS1

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ADPGK-AS1 is involved in pancreatic cancer (PC), strongly promotes tumorigenesis via downregulating miR-205-5p expression and induces epithelial-mesenchymal transition (EMT) process in vivo.

Annotated Information

Name

ADPGK-AS1: ADPGK antisense RNA 1 (HGNC nomenclature).

Characteristics

NA

Function

ADPGK-AS1 works with miR-205-5p/ZEB1 in PC progression, which may provide new insights into in-time diagnosis and therapeutic strategies. [1].

Regulation

ADPGK-AS1 functions through miR-205-5p and regulates ZEB1-induced EMT process [1].

Diseases

  • Pancreatic cancer (PC) [1]

Expression

ADPGK-AS1 is high-expressed in PC tissues and cells compared with the normal [1].

Experiment Forward primer Reverse primer
qRT-PCR 5'-GCCGATGTCGACACAAGCG- 3' 5'-AGCAAATGTGTTCCCATCCCT- 3' [1]

Labs working on this lncRNA

  • Department of Internal Medicine , Shandong University of Traditional Chinese Medicine , Jinan , Shandong , China. [1]
  • Department of Digestive Disease , the Qilu Second Hospital of Shandong University , Jinan , Shandong , China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Song S, Yu W, Lin S, Zhang M, Wang T, Guo S, Wang H. LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial–mesenchymal transition. Cancer biology & therapy. 2018, 19(7):573-83.

Sequence

>gi|100287559|ref|NR_040107.1| Homo sapiens ADPGK antisense RNA 1 (ADPGK-AS1), long non-coding RNA

000001 AAAAGTACAA AGAAAGGAGG TAGTGTCATT TGGAAGAACC TTAAATATGC AGTGTCACTG AAGTCAGGGG AAGAAAAGAA 000080
000081 TTTCACGGAG AAGGGCGTGT TCAATGCGTG GAAGGCTGCA GAGTAGATAA TGAAGATTCA AAAAGGCAAA TCTGAGAGGA 000160
000161 GTTGCAGTAC AGTCGTGTGG TTTCTAGACT ACACGGCGTT TCGAAAGTGG GTAAAGGCAG ACATCACGCG TCTTCAAGAA 000240
000241 GTTCAGAAGA AAGAGGAAGA GTGTTGTCAT AGTGGGTAAG GTCAAGTATC TTTGATTGCA AAACAACAGT CGCCAGAAGA 000320
000321 GAAGGGGCTA AAAGTTGGAA CGAGGAAGAA GGCTCGGAGA AAGGTGTCAG ACAAAGCGGG ATTAGCAAGA AGCTGTTAGG 000400
000401 GCTGGTCCTA CCGGGATGAG AGAAAGGCGC AGAGGCCAGC CGAGTGGAAA GAGCAGCGGT GACGAACCGG GTTCCACTCA 000480
000481 GACGTCCGAC ACTTCTCGCC AAGGGGCCAG CGCGGACAGC AGCGCCTCCC GGGGACCTCT GAGAAGCCCT GTTTCTGCGC 000560
000561 GGCTCCGCCC GACCTCCAAG GCCGACCTCG GAGGCTCAGA GACCCAGGCC CCGTTGGCAC TCACCCCACT GCCACGCGGC 000640
000641 GCCAGCGCCG GACTGGCCGC ACGATAAGCG CGTCCCAGGC TGCCGCCAAC CGGCCCTCGG GGGAGACGGG TCCCGGGGGC 000720
000721 GCAGGCGCGG GCCCCAGACA CAGCGAGCTC CAGAGAGAGC GCAGCGCCGA GCCTGGCAGC TCTGGCTCCA GCAGGAAGAC 000800
000801 GCAGCCCACG GCCAGCGCCA GGAAGCCCGC GTACGCGGAG CCGCGCCACA GCGCCATGGG GACCCAGGCG CCGCACCTGC 000880
000881 GCGAACCAAC TCCTTTCCTA GCCCGCGCCT CTTCCGGGCT CGGCGCGCGC CGATGTCGAC ACAAGCGCTA CGTCACAAGG 000960
000961 GTGCGCCACG GGGCCCCCCA AGGGGCGGGG CGACGGGCGG CGCCAGGACG GAGCGAGGGG GGACCCCACG CCTCAGTCCC 001040
001041 AGGCCTGGCA CTGCGGTGTT GCCGCCCCGG AGGAGGTGGG ACAACGGCGG TTGTGCCAGT CCGGGCGCTG CACCCCCTTC 001120
001121 CCGGAACTCT AATCGTATCC CCAAATAGAG GGATGGGAAC ACATTTGCTT TCGCAGTAAA ACGAAACGGA CAGATTGTGA 001200
001201 AGAAGCGGAC AAACCTCGCG TTAATATTCG AACCAGTGGG TGTCCCCATT GGCACGGATC ACACCCCCAT CTTTTAATCC 001280
001281 CTCCCTCCGC CCGTGTCCCC TCATTTGCTA GACTTGTCCT CTTCCAGGCC TAGTGCTCGG CGCTTCTGAG AGGAATAGGC 001360
001361 TCACAGAATA GCGGCGCTGC CGAGACCCCT GGGGTACGCG AGGCAGGGGG ATTCCGCCCC TTTGGAAGGT GGCCGAGACC 001440
001441 CTCAGCCACT AAAGGACTTC GTCGAGACAG GAGAGCCCGC AGAGATCGTT CTCTTCTGGA TAACCAGATT ATTCCACAAT 001520
001521 CAAACTTTAA CCCTTTTGGG GGCGCTGTTC CCTTTAACAA ACTCTGGAAA ATGTACACAA TCTTGTGCAC AACACGAGAG 001600
001601 TTATGGACCT GGGTTGAGAA ACGCTGCTTT CTTTTGTTCC CCCTTGGTGA CATCACTTAA ACCCAGCCCT CTCTTCGCTG 001680
001681 ATACTTTTCT GTGCATGAGG CTAGGTTGAG AGACAGTGAA GCTAGGCTGG GTACCAGCTC ATTCTCATCA GCCACAATGC 001760
001761 CCGGCCTAGT CTTGTTCCCT GGTTTGTTTC CACTTTTCCA ATTCTCTCGG CTCCTGACCT TGGCTTTGTG TCCAGTTTTC 001840
001841 CACTGTGACC CTGACCTTTG GACTTGGCAG CGAAACTTTA TTTCCCTAAC TTTGATCTTG GGCATTAGTC TTCATTCTCC 001920
001921 TCAGCCCCAC CTCATCAGAA CTTCCCCATC CTGGTCATCT ACCTTCCCGC AGTTCATCCT ACCCAGCCTA CCTGACCATG 002000
002001 CCATCCCTTT CGACAAAGAT ATTCACACAG GAACAGATTT GGGCTACCTT GGAAAAGAAG CCAAAGAGCC AGTCAGATCT 002080
002081 TTATGAAGCC ATGAAAGCCA TCTTCCCTAG AGTTGCCTGT CACTTCTCTC TCCTTAGGGA GACATGTCAG TCAGTTCCTA 002160
002161 GAGAAACTGC TTCTTCTCAC AACCCTCAGC TGTCAGGTTT CCCTGGCACC CAGAGGGGAC TGAGCCAGCA GCTGACCTGA 002240
002241 AAACAGCGAG TCTGCTGACT GTCCAGCGAT CATTTCCCTC TATTGAGAAT TTTAACCAAG TTTCTGTTGT CTGTAGTTAT 002320
002321 TTGATATTGG CTGTGGACCC ACAAAGTCAC ACAAGGCTAA AGGGTGGACA GCACGGAAGA GGCAGTACAT CTTAACAAAA 002400
002401 TCAGGGTTCT GGATGAAGGG AGGGGTGGTG AATGGTTGCT GCAATCAACA GTTCATACTT CAATGGAAAG AAGGTGGGAT 002480
002481 TTGATTCCTG GCTGCAAATC TTCACTCTGT CACCTGCTAT CTGTGTGCCC TCAGGGTCTC ACTTTGTCTC CCAGGCTGGA 002560
002561 GTGCAGTGGC GCAATCACCA CTCACTGCAG CCTCACCTAC CGGGCTCAAG TGATCATCCC ACCTCAGCCT CTCCAGTAGC 002640
002641 TGCGACCACA GGCACGTGCC ACTAAATGAT TATTTTTTCA AGGGAGAAAT CATGCCTGTC ATACAAATAA AAAATGAACA 002720
002721 AGTGTAAAAG
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