IL1R1-AS1
IL1R1-AS1, IL1R1 antisense RNA 1 is a long non-coding RNA that could be a novel circulating biomarker for the determination of oral squamous cell carcinoma (OSCC).
Contents
Annotated Information
Name
IL1R1-AS1: IL1R1 antisense RNA 1 (HGNC:53898)
Aliases
AC007271.3
Characterstics
IL1R1-AS1 located at chromosome 2q12.1 is a long non-coding RNA gene, involved in oral squamous cell carcinoma.[1]
Function
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Regulation
AC007271.3 was up-regulated approximately 2-fold in OSCC cell lines. [1]
Expression
In an expanded case-control study, lncRNA AC007271.3 was differentially expressed and its aberrant levels in OSCC patients were significantly associated with clinical stage, especially in early-stage disease. AC007271.3 overexpression was significantly associated with degree of pathological differentiation (p=0.022), clinical stage (p=0.005), lymphatic metastasis (p< 0.002), and smoking history (p=0.011) but not with age, sex, or alcohol history. [1]. It was also up-regulated in breast cancer cells.[2]
Diseases
Labs working on this lncRNA
- Department of Oral & Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China
- State Key Laboratory of Organ Failure, Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
References
- ↑ 1.0 1.1 1.2 1.3 Shao T, Huang J, Zheng Z, Wu Q, Liu T & Lv X. SCCA, TSGF, and the Long Non-Coding RNA AC007271.3 are Effective Biomarkers for Diagnosing Oral Squamous Cell Carcinoma[J]. Cellular Physiology and Biochemistry. 2018, 47(1):26-38.
- ↑ 2.0 2.1 Huang L, Zeng L, Chu J, Xu P, Lv M, Xu J et al. Chemoresistance‑related long non‑coding RNA expression profiles in human breast cancer cells[J]. Mol Med Rep. 2018, 18(1):243-253.
