DICER1-AS1

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DICER1-AS1 has a role in proliferation, invasion and autophagy of osteosarcoma cells.

Annotated Information

Name

DICER1-AS1: DICER1 antisense RNA 1 (HGNC nomenclature).

Characteristics

DICER1-AS1 has a chromosomal location of 14q32.13 (HGNC nomenclature).

Function

DICER1-AS1 regulates the proliferation, invasion and autophagy of osteosarcoma via miR-30b/ATG5 axis, providing a novel insight for osteosarcoma tumorigenesis [1]. Xenograft assay in vivo indicates that DICER1-AS1 knockdown inhibits the osteosarcoma tumor growth and protein expression level of ATG5. DICER1-AS1 knockdown suppresses the migration and invasion of osteosarcoma cells [1].

Regulation

lncRNA DICER1-AS1 is functionally regulated via miR-30b/ATG5 pathway [1].

Diseases

  • Osteosarcoma (OS) [1]

Expression

Significant up-regulation of DICER1-AS1 in multiple osteosarcoma cell lines has been observed [1].

Experiment Forward primer Reverse primer
qRT-PCR 5'-TGACCAGTCTTACCCCTCCT- 3' 5'-CTGAAG CACCTGAAATGCG- 3'[1]

Labs working on this lncRNA

  • Department of Orthopedic, The 117 Hospital of The PLA, Hangzhou, Zhejiang, 310012, China. [1]
  • Department of Orthopedic, The 117 Hospital of The PLA, Hangzhou, Zhejiang, 310012, China. [1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Gu Z, Hou Z, Zheng L, Wang X, Wu L, Zhang C. LncRNA DICER1-AS1 promotes the proliferation, invasion and autophagy of osteosarcoma cells via miR-30b/ATG5. Biomedicine & Pharmacotherapy. 2018, 104:110-8.

Sequence

>gi|400242|ref|NR_015415.1| Homo sapiens DICER1 antisense RNA 1 (DICER1-AS1), long non-coding RNA

000001 GAGGCGTTTG CGGCCCAGCG CCTGGACTGG ACCTTGGCGT TGGGCCGCAG TTGCCCGGAG TTTTTGGGGC CCCCGGGAAC 000080
000081 CCGCGCGCCG AGGCCGGCTA AGTTTGGCAG ACTCTCTGAG CTCTCGGAAT TCGACTGCCT CCATTGTTGC TCCTTCTGGC 000160
000161 ACCCACAGAC CACATCTCTT CAGTGGACCC CCTGATAGGC CGGTTTGCTC CAGAAGAGAC GGGGTTTCAC CATGTTGGCC 000240
000241 ATGATGGTCT CGATTTCTGA CCTTGTCATC CGTCCGCCTT GGCCTCCCAA AGTGCTGGGA TTACGGGCGT GAGCCACCGT 000320
000321 ACCCAGCCTG CTTCCTGTTT TAACAGACGA AGAAATGGAA TAACTTCCAA CAAGTTGGAG CTGAAGGAGT GCCCAGGCTG 000400
000401 CGGATGGAGG AAGGACGTGC TCGGGAGAAG GTGAAGATGG GAGAGAAGCA AGATCTTCTG TGTTTGGACC AAGGACACAT 000480
000481 TTCCTTACTC CATAGCAGCT GTGGTCAGTG GCTTAGCTCG GACAAGGAGA TGAGAGCCCA TGTGTTGTGA GGGTTCTTCT 000560
000561 GGGAACTCTG AGAAGGCAGG AGCCGCCCCC GCCCTTCACT GCCTCTCTTC CATTCTGCAG CATGGAATAT GGATGTGTGG 000640
000641 TCTGGATGTA CAGACACCAT TTTGGACCAT AAAGACAAGG ACGATTGTCT AAGGATGACA CAGCCAGAGC ACTGAGAGTG 000720
000721 GCGAGAAGGA CAGGGGAGCT GCTGTGCCAA GCAGGACTGT CTCTCTTAAG AGAAAAATAA AATTTATTGG TGTTTAAACC 000800
000801 ATTAAAAAAA AAAAAAAAAA AAAAAAAAAA
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