LINC00092

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LINC00092 is correlated with aggressiveness of ovarian cancer in vivo and in vitro and clinical outcome of ovarian cancer patients, interacted with 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), and involved in increased glycolysis levels in ovarian cancer metastasis.

Annotated Information

Name

LINC00092 : long intergenic non-protein coding RNA 92 (HGNC nomenclature).

Characteristics

LINC00092 is located on the intergenic regions of 9q22.32 with no functional annotations previously.

Function

LINC00092 binds with a glycolytic enzyme PFKFB2, thereby promoting metastasis by altering glycolysis and sustaining the local supportive function of cancer-associated fibroblasts (CAFs). Overall, it has been shown that a positive feedback loop in the metabolism of CXCL14-positive CAFs and ovarian cancer cells that is critical for metastatic progression [1].

Regulation

NA

Diseases

  • Ovarian cancer (OC) [1]

Expression

LINC00092 is overexpressed in metastatic lesions of ovarian cancer, associated with poor prognosis and correlated with stromal CXCL14 expression in ovarian cancer specimens [1]. LINC00092 is a key upregulated lncRNA in ovarian cancer cells when treated with CXCL14 from CAFs [1].

Experiment Forward primer Reverse primer
qRT-PCR NA NA

Labs working on this lncRNA

  • Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P.R. China. [1]
  • Department of Pathology, West China Second Hospital, Sichuan University, Chengdu, P.R. China. [1]
  • Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, P.R. China. [1]
  • Department of Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania. [1]
  • Department of Surgery, Emergency Medicine, Kaiser Santa Clara Medical Center, Stanford University, Santa Clara, California. [1]
  • Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, P.R. China. [1]
  • Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P.R. China. [1]

References

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Zhao L, Ji G, Le X, Wang C, Xu L, Feng M, Zhang Y, Yang H, Xuan Y, Yang Y, Lei L. Long non-coding RNA LINC00092 acts in cancer-associated fibroblasts to drive glycolysis and progression of ovarian cancer. Cancer research. 2017:canres-1615.

Sequence

>gi|9547|ref|NR_024129.2| Homo sapiens long intergenic non-protein coding RNA 92 (LINC00092), long non-coding RNA

000001 AGTCCCGCCG ACCCTGCCGG CGCCTCCGCC CTCCCGCCCT CCCGCCCTCG GTTTCCCACG ACCTCGGCGC GACGCGCGCG 000080
000081 GGATCCAGTG GAGACTGCTT TCCCATAGGC CGCCATCCAG GGCGGGGAAG GGAGCGGACC CTCCCGGCTC CAGGTGCCTG 000160
000161 GGCCCCCGGC GGCCTGCGGA GGCCTCGCCC CACGCCACCC GCCCACTGGC CTCGTCTTCG CGCGGGGAGA AAAGCAGCCT 000240
000241 GATTCGGAGG AACGGGTTGC TTGGGGCGGC TCCCAGCTCG AGTTGTGGGC CCCGCCGCGG GTGCCCTTCG GAAACGCGCT 000320
000321 GACACCAGGC GAAGCCGCCT CTGCCCGGAC GCAGCCCGAC ACTTGGCCCG CGGGGTTCCC CGGGACGCCT GAGAGTAATG 000400
000401 GGCGCGAGGG GGAAAGCCGA ACGGCCTCCC TGTGCCCGGC GCAGGCGGTG CCCCCTAGCT GGGTTCGCCG CGGCGGCGCT 000480
000481 GCGAGCCCCC GACACTGAGG ACTTTTGGTC CAACAGTCCG ACGGGGCCCG GTGCGCCGTT CCCTCCGCCC TCTCCCCGCT 000560
000561 CCCCGGCCCG CGCGTCTTGG AGGGTGGGTG AATTGTCGGA AGCACTCTAC GCCTGGCCAA CCCAAACCAG GAACCTCCGC 000640
000641 ACCAAACAGC CCACGTTGCT GCTGCTCTGG GGTTTTAACG GCCAAGGGAG ACTGGAGAAG GGGTGTTCTG CCTTCCCATT 000720
000721 CTCTTAGGCC CGTCCACTCC CCATCCCCAC AGTTTGGAAG TGGCCTTTTC TGAGGACTCC AGCGCAAAGC ATGTTTCTCC 000800
000801 TTTTGAGCTG CGGAAGCCTT GCTTGTTCCC GCCATTGGGA GGGCATTCCA TCATCTGCAG CTGCCTTCCT CGGTGGGCCT 000880
000881 TGTCCCTTAG CGTCCACCTA GGGGACATTC TAAGCTTCTT GAGACCTGCT TGTCCACCCC AACATGTCTC AGCATATGGC 000960
000961 TGTGCCCTAA GGGGTCTTTG AGGGCATTTT AGGAGGTGAG CGGCGCCCCT ACCTGGGCTC CGCGGGGCCG ATTCGGTTTG 001040
001041 CCCTTTGCTG GCATGTCAGT GAATTAACTG CTGTCCTTGG GATGACCTGC CCTATGATTT GGCCTCTGGA GCATCCCGGG 001120
001121 TGTGTATTTC AGAACTCCTC CCATCTTATC CACCTGCTGA AGGCCTGGCC CCCTGATATG GTTTGGCTCT GTTTCCCCAC 001200
001201 CCAAATCTCA CCTTGAATTT TAATAATCCC CACGTGTCAT GGGCGGGACC AGGTGGAGGT AATTGAATCA TGGAGGTGGT 001280
001281 TTCCTGAACG CTGCTCTCGT GACAGTGAGT TCACAAGATT TTTTTTTTTA ACGGAGTATC ACTCTGTCAC TCAGGCTGGA 001360
001361 GTGCAGTGGC GCGATCTTGG TTCACTGCAA CCTCTGCCTC CCGGGTTCAA GAGATTCTCC TGCCTCAGCC TCCCGAGTAG 001440
001441 CTGGGATTAC AGGTGCGCGC CATCACGCCC GGCTAATGTG TATTTTTAGT AGAGAAAGGG TTTCACCATG TTGGTTAGGC 001520
001521 TGGTCTGGAA CTCCTGACCT TGTGATCTGC CTGCCTCGGC CTCCCAAAGT GCTGGGATTA CACGCGTGAG CCACTGTGCC 001600
001601 CAGCCGATCT GATGCTTTTA TAAAGGGCTT TCCCCGTCCC CCTTCCTCTC TCTCACCACC CTGTGAGAAA GGTGCCTTTC 001680
001681 TTCCCCCTTC ACGTGAACTG CCTCCATGAT TGTAAGCTTC CTGAGGCCTC CCCAGCTATA AGGAACTGTG AGCCAATTAA 001760
001761 ACTGCTTTAT AAATTAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 001840
001841 AAAAAAAAAA AAAAAAAAAA A
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