TBILA
TBILA, promotes non-small cell lung cancer progression in vitro and in vivo.
Contents
Annotated Information
Approved Symbol
TBILA
Approved Name
TBILA: TGF-beta induced lncRNA, RP11-757F18.5
Characteristics
TBILA is an RNA annotated as RP11-757F18.5, which is located on Chr3, and was found to inhibit growth during siRNA screening experiments [1]. As the lncRNA is a TGFβ-induced lncRNA, so is named as TBILA [1]. TBILA exerts its biological function in the nucleus. Using rapidly amplified 5′- and 3′- cDNA ends, it is found that TBILA is an intronless transcript comprising 1698 nucleotides [1].
Function
TBILA is upregulated in NSCLC and promotes tumor cell progression in vitro and in vivo [1]. TBILA enhances RhoA activation via cis-regulating HGAL expression [1]. TBILA promotes the S100A7- JAB1 pathway by binding to nuclear S100A7 protein [1].
Regulation
TBILA is directly upregulated by TGFβ/Smad signaling pathway in NSCLC [1].
Diseases
- Non-small cell lung cancer
Expression
TBILA promoted NSCLC progression and was upregulated in tumor tissues [1].
Labs working on this lncRNA
- Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China
References
Sequence
>gi|284080|ref|NR_157393.1|Homo sapiens TGF-beta induced lncRNA (TBILA), long non-coding RNA
000081 GGAGGTTAAA ACAGTCAAGC CACAGACCTG TAGAAAATAT AGTATCAACA ACTCTCAAAT CTGAAAACAA ACACCCAGTA 000160
000161 ACAAAATGGG CAAAATATTT GAACAGACAT TTCACCAAAG GAACTATACA GATGAACATT AAAAGATGCT AAACATTGTA 000240
000241 GTTATTAGGG AAGTGTAAAT CAAATCCACA ATGGAACACT TTTACATACT TATTACAATG GCTATAAAAC CCTGACAATA 000320
000321 TCAAGTATGG CAAGGTATGC AAAGCAACTG GAAGTCTCAT GCATTGCTGA TGAGAATGCA AAATGACAGC CTTTTTGGAA 000400
000401 AGAAGTGATA AGGACAGAAG GCAGGGCTTT ACTGGGTAGA AGAGGGTGGT TCACTGGCAA AGGTCCCACC CTCAAGCCTT 000480
000481 GAAACCGAAG CCCTAAATGA GAACAGTTAT CCCTGTTATC CTGCCCAAAT GTTACTCTTT AGCCTGTCCA GCCCCCCTAT 000560
000561 CCCGTGCCCA TATAAACCCC AGACCTCAGC TGGCAGACAG ACAAGCGGCT GAACATCAAG AGGAGAAGAA GCAACTGAGT 000640
000641 GTCAGAGATG TGGCTTAACT TCAGGTGGCA TGACTTCAGG GAGGAGCCCG GCCAGAGACA GCAGACTTCA GGGAAAGGTC 000720
000721 ACTTTCTTCC TGCACCATCC CCTTTGCAGC TCCCCTTCCA CTGAGAGCCA CTTCCACCAT TTAATAAAAT CGTCCACATC 000800
000801 CATCAACTTT CAAACCATTC ATGCAACCTG ATTCTTCCTG GATGCTGAAC AAGAACCTGG GTACCAACAG GGCAGGGTGT 000880
000881 AAAAGGCTGC CACCCTGACT CTCCATTGAG TGGGTTAACA CTTAGCTGTC CACGGATGGC AACTGCTAAA AGAGCATGAA 000960
000961 TTGTAACACA TCCCTAAATG CTGCTGTTGG GCTGGAGCCC AAAAGTGCTC ATCGAAGCCC TGGCACCCGC TTGCCTGCGT 001040
001041 GCTCCCGCTC CCACAGAGAG TTTGAGCATG GTGGTGGCCA AGTAAGTAGG CCACACCCCT GTCGCAAGTC CCGAGAAGGG 001120
001121 GTCAAGGGAA CTCTCCCATC TCAGAAGTAT GGCAATTTCT TATAAAATTG AACATAGGGT TACTGTACAA CCTGGCAATT 001200
001201 TCACTCCTAG GCATTTAGCC AAGTGAAACT TATGTCCTCT AAGACTGTGT GTACAAATTT TTATATGTGC TTTACTCATA 001280
001281 ATAGCCGAAA TACCCTGGAA ATAGCCCAAC TGATCTTCAT TGAGTGAATT GCTAAATAAG CTCTGTGTTA TATTACATCC 001360
001361 ACACAACAGA ATCCTGACCA TCATTGAAAA GGAGTGGACT ATTAATACAT GCAATAACTT GGATCAATCT CAAATGCATT 001440
001441 ACACTAAGTG AAAGAGACCA GACTTAAAGC CTACCTTCTG TGACATTAGA GATAAGGTGA AACCACAGGA ACAGAAAACA 001520
001521 TATTAGTGTT GCCAGGAGCA AAAGGTGGGG GAGGTGTTGA CTTTCAAAGC ACAGGAGGAA ATTTTTTGTT GTTGTTCTTT 001600
001601 ATCTTGATTG TGTTAGTGCC CACATGACTG TATGCATTTC TCATAATTCA CAGAACTGTA TACTAATAAG GGTGCACTTC 001680
001681 ACTGCACATA AATGAATCTC AACAGACAAA AGGTTAAAAA AGAAAGAAAT CTCGGGACAG GAATCATGGA TTTTTGTATT 001760
001761 ATCCTTGTAT TTGATGGTTG TTTCCAGTTT GGTCACTCAT CTGTTTGTTC ATTCCTTTAA CAAGTATGTG TCGAGTGCCT 001840
001841 ACTATGTGCT GGGCACTGTA GGTTCAATGG TAAGAAAAGC AGATACAGGA CTGCTCTTGT GAAGTTCCTT GAAAGAAATA 001920
001921 AAACAAAGTG CAAAATA
