TNRC6C-AS1
TNRC6C-AS1, regulates UNC5B in thyroid cancer to influence cell proliferation, migration, and invasion as a competing endogenous RNA of miR-129-5p
Contents
Annotated Information
Approved Symbol
TNRC6C-AS1
Approved Name
TNRC6C-AS1:
Characteristics
TNRC6C-AS1 is a competitive endogenous virus residing on chromosome 17q25.3 [1].
Function
TNRC6C-AS1 influenced the progression of TC through regulating UNC5B expression as a competing endogenous RNA (ceRNA) of miR-129-5p [1]. TNRC6C-AS1 downregulation could suppress the viability and mobility of TC cells as well as inhibit tumorigenesis [1]. TNRC6C-AS1 could competitively bind to miR-129-5p as a ceRNA and upregulate the expression of UNC5B, a target gene of miR-129-5p. Therefore, the downregulation of TNRC6C-AS1 could silence UNC5B, thus suppress TC development [1]. TNRC6C-AS1 and UNC5B might be potential targets for TC treatment [1].
Regulation
LncRNA TNRC6C-AS1 and UNC5B were overexpressed while miR-129-5p was downregulated in TC [1].
Diseases
- Thyroid cancer [1].
Expression
TNRC6C-AS1 is expressed during thyroid cancer [1].
Labs working on this lncRNA
- Department of Nuclear Medicine, the First Hospital of Jilin University, Changchun, Jilin, China.
References
Sequence
>gi|100131096|ref|NR_040071.1|Homo sapiens TNRC6C antisense RNA 1 (TNRC6C-AS1), long non-coding RNA
000001 AGGTGGGGAA ATGGTCAAAG AGCGATGGGC CCAGAAAAGG GTCAGACCCA GATGGAGATG CCACTGGCTG CTAGCAGACC 000080
000081 CCCACGCTGG GTCTAGCCCA CCCAATCCCA TGGGGATGCT CCTGTGCTCT GCAGACATCT GGGTGCTGCC ACAGGGGCCC 000160
000161 GACAGAGTTG GCATCTGGGT GGATCTGAGC CAAGTGGTGC TTCTGGGCCT CAGCAAGTAG CTGGTGCTGA TTCTGGGCAG 000240
000241 CCAACTGTGG CAGCATCTTC AGGTGCGAGT GCTGCTGGGT GAAGCTGCGT GGGCAGTCCA GAAAGTGACG TGACAGTCCA 000320
000321 CAGGGACCGA CGTAGGGTTT CCAGCCCCTA TCTGTGCAGA TGCTGTCCTC CAAACCATCA CGGTCCCTCT CTGGCTGGGG 000400
000401 ACGTGCGCCT GCCACTGCTG GCTTGCCAGC ATGATCATTG GTTGTGACCT GTTGAGCCCA TCTTGCCAGC CTCACAAAGG 000480
000481 ACAGTACTAG CTGCTTATGA CAGGAAAGTG GAAGAACTTG GCCTGGATAT TTCTGGAGAA TTACCGTGTG TGCTAGTCAG 000560
000561 TCTTTCGTGT CAACCAGGCC AGGCTGTGGG GCCCAGTGAT CTCATCGAGA GGGGCCGAGG TGTTGCTGTG ATCGTGTGCT 000640
000641 GCTGGAATGT GGTGAACACC TACAGTCGAT TTCACCTAAA GATCATCCTT GAGAATGTGG GTGGGCCTCA TCCTATCAGC 000720
000721 TGAAAGCTTT AAGAGCAAAA CCCGAGGTGT CCCAGAGAGG GAATTCTGCC TTGAGACGGC GGCTTCCCAC TCCCACTGGA 000800
000801 TGTCCAGCCC GCGGCCCCAC GGCTGGGTGA GCCCGTCCTC TCCTCGTTTC TGTCTCCGGA CCCACCGTGT GGCCCCAGAC 000880
000881 CCTCCAGTGA GGACCTCCCG TATTTCTTCA GAGCAGCCCT TGCGTGCTGG AGGCCTGGGC TTCAGTGTGT CCCTGGGTGC 000960
000961 CCTGGGGCAT GTTCTGTGAC CTCCCAGCTC CTCGCCTCAT GGGGCCGCTG TATCAAGTGA CACAGTTTGT GTGCTGCGTA 001040
001041 CCATGCCTGG CACCCATTTG AGGTGTTGCA AGGAGGCCAT GTTTGCTCGA TGAGAGCAGC CTAAGATCTA CAAACTGTTG 001120
001121 TTCGAGTGGA TGGGAACTTG ATGCTATTTT CAGGCTGAAT GACAAGACTC CGCGATGCTT CTCGGCCTGG GCTGCACAAC 001200
001201 GGAATCTACC AGGGAGGTTT TAAAAACACT GGTACTTGCT GGAGGTGGTG GCGCCTGTCT GTAATTGCAG CTGCTCCAGA 001280
001281 GGCTGAGGCG GAGGATTGCT TGAGCCCAAG AGTTTCGGTT TATTTGCTTT TTCAGAGTCT TGCTCTTGCC CAGGCTGGAG 001360
001361 TGCAGTTCCA TGATCTCGGC TCACTGCCTC AGCCTCCCAA GTAGCTGGGA TTACAGGTGC ATACAACCAG GCCTGGCTGA 001440
001441 TCTTCGTATT TTTAGTAGAG ATGGGGTTTC ACCATGATGG TCAGGCTGGT CAAGATCTCC TGACCTCAAG TGATCTGCCC 001520
001521 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GACATGAACC ACAACACCTG CCGAGCCCAG GTGTTTTGAA TCCAGCACGG 001600
001601 GCAATGGCAA GACCCTGTCC CAACAAACAA AAAAACACTG GTGCCTGAGG CCCACCCCGA GAGATTCTGA TTGAGTTGAT 001680
001681 TTGGATTTGA ATTATCTTTA AAATTTTGGA TGTGAATTTT TTTTTTTTTT CTTGGAATGG AGTTTCACTC TTGTTCCCCA 001760
001761 GGCTGGAGTG CAACGGGACG ATCTTGGCTC ACCGCAACCT CCGCCTACTG GGTTCAAGCC ATTCTCCTGC CTCAGCTTCC 001840
001841 CAAGTAGCTG GGATTACAGG CATGTGCTAC CATGCCCAGC TAATTTTGTA TTTTTAGTAG AGACAGGGTT TCTCCATGTT 001920
001921 GCTCAGGCTG GTCTTGAACT CCTGACCTCA GGTGATCCGC CCGCCTCGGA CTCCCAAAGT GCTGGGATTA CAGGCATGAG 002000
002001 CCACCATGCC TGGCCGGATG TGAATTATCT TAAAAATTTT CAGGTAATTC TAATGGGCCA AGGTTGAGAA CCCCTGCTCT 002080
002081 GGGCCCATCC GAGCACCAGG CTGTCACAAA CGCATGCATG CACTCACGCC CGTGGGCTTG GGGGGCTTCG GAAATGTGCT 002160
002161 TCTGCTTTTT TGAGATGGGG TCTTTCTGTT GCCCATCCCG GAGCACAGTG GCACGATCAC AGCTCACTGC AGCCTCGACC 002240
002241 TCCTGGGCTC AGGTGATCCT CCCGCCTCAG CCTCCTGAGT GTCTGCTTCT GGTTTTCATG ATGACCTGGG GCCCAGGCAT 002320
002321 ACTACACTTG TGCTGTTCAG GGGCCAGTCC TGCACCAGGA GCCCATCAGC CACAGCTCCG CCGAGAAGCA CTGATATGCA 002400
002401 GAGCTAAGCA GCTTTGTTTC CACGTGGATC CTGCGTAGGT TTTCTTGGTC CATCCGTAGA CACCGCACTC CTGCAGAGGA 002480
002481 TCTTCTCGGG ATGCCCCACT GTCTCTGTTT TCCCTCTTCA CTGAACACTC AGTCGGGGCT CGCCATGATG CCTCTGTGTC 002560
002561 TGCTGGCTTC TCCCCCATTG GAACAGCCTT CTTGGCACGC CACACTGCTA GCTGCTGGGC ACTGTGCTTT CTGCCTTTAC 002640
002641 CGTTCTGCCG TGATGTTGCC AAAATAGCAG CAACAACAAC AACAACAAAG GCTGGGCACC TGGCTCATGC CTGTATTCCC 002720
002721 AGCAGTTCGA GATCAGCCTG GGCAACATGC CCCAACTGGA CCCTAGGCAA AAGTGAGTGG CACTCCTCTG CCAGGACTCC 002800
002801 AGGCAAGCCC CGGCATCTTC TTGCTGCCGT CCCAGACAAC AGAAGTTACC AGATGAACAG ACTTGGATGG GCCACGGGGG 002880
002881 TGGAGAGCTG GAAAGCTTGG CTGTGCCTCT CGATGATGAT TAAGATTTCA ATATTTACAG CAAAACCACA AAGCAAATGA 002960
002961 TAGAATAAAG CAAAACAATG GAAAATCTGA GTTCACTCGT GAGAGAGGTA CGTATGTGAG CTCTGAGGAA ATTACAGAGG 003040
003041 GAACGCATGC AGCGGGACAG CTCTCCCAAT CGCAGCGTGC AAAGTAGACA TCCATAGTGT CTTTTGAAAA ATGAAAAACA 003120
003121 CATTACTTTG AACAGCCAAG AAAAAAATTG CAATTTATTA AGATTCAATA AAGCGTTGTA CTTTCGAAA
000081 CCCACGCTGG GTCTAGCCCA CCCAATCCCA TGGGGATGCT CCTGTGCTCT GCAGACATCT GGGTGCTGCC ACAGGGGCCC 000160
000161 GACAGAGTTG GCATCTGGGT GGATCTGAGC CAAGTGGTGC TTCTGGGCCT CAGCAAGTAG CTGGTGCTGA TTCTGGGCAG 000240
000241 CCAACTGTGG CAGCATCTTC AGGTGCGAGT GCTGCTGGGT GAAGCTGCGT GGGCAGTCCA GAAAGTGACG TGACAGTCCA 000320
000321 CAGGGACCGA CGTAGGGTTT CCAGCCCCTA TCTGTGCAGA TGCTGTCCTC CAAACCATCA CGGTCCCTCT CTGGCTGGGG 000400
000401 ACGTGCGCCT GCCACTGCTG GCTTGCCAGC ATGATCATTG GTTGTGACCT GTTGAGCCCA TCTTGCCAGC CTCACAAAGG 000480
000481 ACAGTACTAG CTGCTTATGA CAGGAAAGTG GAAGAACTTG GCCTGGATAT TTCTGGAGAA TTACCGTGTG TGCTAGTCAG 000560
000561 TCTTTCGTGT CAACCAGGCC AGGCTGTGGG GCCCAGTGAT CTCATCGAGA GGGGCCGAGG TGTTGCTGTG ATCGTGTGCT 000640
000641 GCTGGAATGT GGTGAACACC TACAGTCGAT TTCACCTAAA GATCATCCTT GAGAATGTGG GTGGGCCTCA TCCTATCAGC 000720
000721 TGAAAGCTTT AAGAGCAAAA CCCGAGGTGT CCCAGAGAGG GAATTCTGCC TTGAGACGGC GGCTTCCCAC TCCCACTGGA 000800
000801 TGTCCAGCCC GCGGCCCCAC GGCTGGGTGA GCCCGTCCTC TCCTCGTTTC TGTCTCCGGA CCCACCGTGT GGCCCCAGAC 000880
000881 CCTCCAGTGA GGACCTCCCG TATTTCTTCA GAGCAGCCCT TGCGTGCTGG AGGCCTGGGC TTCAGTGTGT CCCTGGGTGC 000960
000961 CCTGGGGCAT GTTCTGTGAC CTCCCAGCTC CTCGCCTCAT GGGGCCGCTG TATCAAGTGA CACAGTTTGT GTGCTGCGTA 001040
001041 CCATGCCTGG CACCCATTTG AGGTGTTGCA AGGAGGCCAT GTTTGCTCGA TGAGAGCAGC CTAAGATCTA CAAACTGTTG 001120
001121 TTCGAGTGGA TGGGAACTTG ATGCTATTTT CAGGCTGAAT GACAAGACTC CGCGATGCTT CTCGGCCTGG GCTGCACAAC 001200
001201 GGAATCTACC AGGGAGGTTT TAAAAACACT GGTACTTGCT GGAGGTGGTG GCGCCTGTCT GTAATTGCAG CTGCTCCAGA 001280
001281 GGCTGAGGCG GAGGATTGCT TGAGCCCAAG AGTTTCGGTT TATTTGCTTT TTCAGAGTCT TGCTCTTGCC CAGGCTGGAG 001360
001361 TGCAGTTCCA TGATCTCGGC TCACTGCCTC AGCCTCCCAA GTAGCTGGGA TTACAGGTGC ATACAACCAG GCCTGGCTGA 001440
001441 TCTTCGTATT TTTAGTAGAG ATGGGGTTTC ACCATGATGG TCAGGCTGGT CAAGATCTCC TGACCTCAAG TGATCTGCCC 001520
001521 GCCTCGGCCT CCCAAAGTGC TGGGATTACA GACATGAACC ACAACACCTG CCGAGCCCAG GTGTTTTGAA TCCAGCACGG 001600
001601 GCAATGGCAA GACCCTGTCC CAACAAACAA AAAAACACTG GTGCCTGAGG CCCACCCCGA GAGATTCTGA TTGAGTTGAT 001680
001681 TTGGATTTGA ATTATCTTTA AAATTTTGGA TGTGAATTTT TTTTTTTTTT CTTGGAATGG AGTTTCACTC TTGTTCCCCA 001760
001761 GGCTGGAGTG CAACGGGACG ATCTTGGCTC ACCGCAACCT CCGCCTACTG GGTTCAAGCC ATTCTCCTGC CTCAGCTTCC 001840
001841 CAAGTAGCTG GGATTACAGG CATGTGCTAC CATGCCCAGC TAATTTTGTA TTTTTAGTAG AGACAGGGTT TCTCCATGTT 001920
001921 GCTCAGGCTG GTCTTGAACT CCTGACCTCA GGTGATCCGC CCGCCTCGGA CTCCCAAAGT GCTGGGATTA CAGGCATGAG 002000
002001 CCACCATGCC TGGCCGGATG TGAATTATCT TAAAAATTTT CAGGTAATTC TAATGGGCCA AGGTTGAGAA CCCCTGCTCT 002080
002081 GGGCCCATCC GAGCACCAGG CTGTCACAAA CGCATGCATG CACTCACGCC CGTGGGCTTG GGGGGCTTCG GAAATGTGCT 002160
002161 TCTGCTTTTT TGAGATGGGG TCTTTCTGTT GCCCATCCCG GAGCACAGTG GCACGATCAC AGCTCACTGC AGCCTCGACC 002240
002241 TCCTGGGCTC AGGTGATCCT CCCGCCTCAG CCTCCTGAGT GTCTGCTTCT GGTTTTCATG ATGACCTGGG GCCCAGGCAT 002320
002321 ACTACACTTG TGCTGTTCAG GGGCCAGTCC TGCACCAGGA GCCCATCAGC CACAGCTCCG CCGAGAAGCA CTGATATGCA 002400
002401 GAGCTAAGCA GCTTTGTTTC CACGTGGATC CTGCGTAGGT TTTCTTGGTC CATCCGTAGA CACCGCACTC CTGCAGAGGA 002480
002481 TCTTCTCGGG ATGCCCCACT GTCTCTGTTT TCCCTCTTCA CTGAACACTC AGTCGGGGCT CGCCATGATG CCTCTGTGTC 002560
002561 TGCTGGCTTC TCCCCCATTG GAACAGCCTT CTTGGCACGC CACACTGCTA GCTGCTGGGC ACTGTGCTTT CTGCCTTTAC 002640
002641 CGTTCTGCCG TGATGTTGCC AAAATAGCAG CAACAACAAC AACAACAAAG GCTGGGCACC TGGCTCATGC CTGTATTCCC 002720
002721 AGCAGTTCGA GATCAGCCTG GGCAACATGC CCCAACTGGA CCCTAGGCAA AAGTGAGTGG CACTCCTCTG CCAGGACTCC 002800
002801 AGGCAAGCCC CGGCATCTTC TTGCTGCCGT CCCAGACAAC AGAAGTTACC AGATGAACAG ACTTGGATGG GCCACGGGGG 002880
002881 TGGAGAGCTG GAAAGCTTGG CTGTGCCTCT CGATGATGAT TAAGATTTCA ATATTTACAG CAAAACCACA AAGCAAATGA 002960
002961 TAGAATAAAG CAAAACAATG GAAAATCTGA GTTCACTCGT GAGAGAGGTA CGTATGTGAG CTCTGAGGAA ATTACAGAGG 003040
003041 GAACGCATGC AGCGGGACAG CTCTCCCAAT CGCAGCGTGC AAAGTAGACA TCCATAGTGT CTTTTGAAAA ATGAAAAACA 003120
003121 CATTACTTTG AACAGCCAAG AAAAAAATTG CAATTTATTA AGATTCAATA AAGCGTTGTA CTTTCGAAA
