ARLNC1

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ARLNC1, plays an important role in prostate cancer progression

Annotated Information

Approved Symbol

ARLNC1

Approved Name

ARLNC1:

Characteristics

ARLNC1 is located on chromosome 16 along with presence of several transcript isoforms that differ in exon and TSS usage [1]. ARLNC1 molecules are distributed equally between the nuclear and cytoplasmic cellular compartments [1].

Function

ARLNC1 has the potential to be not only a mechanistic biomarker, but also a therapeutic target for advanced prostate cancer [1]. ARLNC1 regulates the cytoplasmic levels of AR transcripts [1]. Inhibition of ARLNC1 delays prostate cancer growth in vitro and in vivo [1].

Regulation

ARLNC1 is directly regulated by AR and modestly regulated by FOXA1 [1].

Diseases

  • Prostate cancer [1].

Expression

ARLNC1 exhibited a highly prostate cancer-specific expression pattern, with little to no expression in other tumor types [1].

Labs working on this lncRNA

  • Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
  • Molecular and Cellular Pathology Program, University of Michigan, Ann Arbor, MI, USA.
  • Department of Computational Medicine and Bioinformatics, Ann Arbor, MI, USA.
  • Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Zhang YJ, Pitchiaya S, Cieslik M, Niknafs YS, Tien JCY, Hosono Y et al. Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression[J]. Nat Genet. 2018, 50(6)

Sequence

>gi|100996425|ref|NR_131947.1|Homo sapiens androgen receptor regulated long noncoding RNA 1 (ARLNC1), transcript variant 1, long non-coding RNA

000001 TTTCTTTTTG TTTGCTGCCT TCCGTAGAAG ATGTGGCTTG CTCATGCTTG ACTTCTGCCA TGGTTGTGAG GCCTCCCCAG 000080
000081 CCATGTGGAA CTGTTTTCAG GTGCTGGTTC CATGGCTCTT CCTGAGCCGA AAATAAGGAA ACTCCATAGA CCTTGTCCAC 000160
000161 TGGAACTCGT TCCCATCTAC CCTCCACTCT ATCCAGCCCC ATGAGGACAA GGAACATGAT TGGTTTTGCT CACTGCCGTA 000240
000241 TCTTCCGTAC CTAGTACGTA ACAGGACATC AATAAATATT AGTTGAATGG AAGATTAAAT CAACAAAATG GGTGATGGAT 000320
000321 CTCTGCAGTA AGTGGAAGAG TTCTTCATGG CCCCCAAGGT TATATCCATC TAGAACTTCA GCACGTAATT TCATCTGGAA 000400
000401 ATAGTGCCTT TGCGGATATA AGTTAGGTAA AACTGAAGAT GAGATCATAC TGGATTAGGA TGGGATCTAA ATCCAATGAA 000480
000481 AATGTCTTCA TAAAAAACAG GAAAGAACCC ATAGAAACAC AAGGAAGAAG GTCATGTGAA GATGGAGGCA GAGATTGGAG 000560
000561 GGATGCAGCC ACCGGCCCAG GAATGCCAGC AGCCACCCAG AAGCTGGAAG GAAATGAGGG ATTCTCTCCT AGAACCTTTA 000640
000641 GAGAGAACAT GGTCCTGTGA ACAGCTTGAT TTTGGACTTG CCCATAGCTT GTATACTCTT ACTTTGGATA CAATTTTATC 000720
000721 CAAACTTGGC TAAACAGTTT CTCAGCCTAT GGAAAATTTA AAATGGAGAA GATTCAACTC GATTCTTACA GATTCAAAGC 000800
000801 AAGAAAATGA TGGGAACATA GGAGGAGACC AAGAAAGCCT ATAAAAAGCA AAAATATGAA GTGAACATTG TGGTAGCTTT 000880
000881 AAGATGTTTA GTGTAGCTGC AGGCACCCTA TACACATGAA AACCCCCAAG GGGAATCCCC ATATCACAGT GTAGTGTGAT 000960
000961 ATTTGACATT CGTGATCATC TAGAGATGTA CAGAAAAGGT GAATCTGTGT TCTGTATATT CTGCCTAAGG CAAAGAAATG 001040
001041 TTTAGCTCTC TTTAAAATAG TTCCATAATT TTTTCTAAAA AGCTTTGCTT GAAAACTGTA AGCTTCCCAT ATCTGGAGCA 001120
001121 TTTCACTTTA AATATTTGGA TAAATATGTT ATCTTCTTAC TTGGACATTT CATGTGTTTA GGGATTGTCT TCTAAATTCT 001200
001201 TCCTAATTCA TATAGCTGCT AACACTTCCC GCAGAGCTAA ACCATTACAG ATATGAAATA AAGACCTATT GATTTGACTT 001280
001281 ACTTTTACTT GTAAAACCTT CTGAGTGTTA TAACCTCATT TAATCTTTCA GCATTTACAG TTTCAAGAGT TTGTGTCACA 001360
001361 ATTAGAAGAA TTCAGCTGCA CCTCCAAGTG ACAGCAGTTG CTCTGGTTGG TGGGTGATCT CAGGAGGCTT GAGAATTGCT 001440
001441 TTGTCTGTGA GGGAAGTAAG ACATTTTCAG AGCCCCACTT TAGAAGGTGT GAACTGGCTA GATAATGAAC CCCAGGGCTA 001520
001521 ACGCTGCTAT AGCAGTGGGA AGGAGGTGAT GGGTTTTCAG TTTGGACCTC AAACATCAAT ACCCTCCTGG TACGGGGAGG 001600
001601 AACAGAGTCC CTCCTTTACT TCTCCATTAG AAAGAATGAG ATGGCAAGAC AATGAAACAG GCAAAGTGAA CAGAGATGCA 001680
001681 AGACAAAATT CAGGTGAGAG AGCCAGAGCA TCACTCAGCC ATTCCTGACA TGTAAAACAG GCAACTAGAA ATTTGCAGAA 001760
001761 AGGAAGCGAA GTCTCCATAA AGATGTTTTT AAAGTGAGCT TGAAGTATTT GGAGACAATT CAGTGTTACA TAAAATCTGC 001840
001841 AAATCTCTGG ATAAAGAAGC AGAGATCCCA GCATGGGACA AATGGAGCCT CAAAAGTGGG AAGAAGACAG AGAAGACCAG 001920
001921 GGCAGAATGC ATCTCTTCCT TTCTCTTGGC TTTCCTGGAT AAGGACTGCA TCATTCCTGT GGAAGGACAG GCCATCAGCT 002000
002001 CCGAAACACT GTATGTATTT TCCAGTATAT ACTGCTAGCT GTGTGATGTT GGGAAAATTT GTTACCCTGT CTAACCCCCA 002080
002081 CTTCCCTCAT CTGTAAAATG GAAATAATGA TAGTACCTAC CTATCTCATA GGTGGCAACT ACAAGGGGCA GCACACTCAG 002160
002161 GGAATTAAGG A