CFAP58-DT
lncRNA CFAP58-DT orchestrates signal transduction for interferon (IFN) production and illustrates the essential role of lncRNAs in virus elimination.
Contents
Annotated Information
Name
CFAP58-DT: CFAP58 divergent transcript (HGNC nomenclature. Synonym: ITPRIP-1 [1].
Characteristics
The human lncRNA gene CFAP58-DT (ENSG00000231233.1, Chr10:106111349-106113333 [1.9 kbp], LNCipedia transcript ID:lnc-ITPRIP-1:1,795 nucleotides) is located on chromosome 10, adjacent to the coding gene DANGER (also named as ITPRIP) [1].
Function
lncRNA CFAP58-DT is involved in viral infection and plays a crucial role in the virus-triggered IFN signaling pathway through the targeting of melanoma differentiation-associated gene 5 (MDA5). CFAP58-DT can be induced by viral infection, which is not entirely dependent on the IFN signal [1]. MDA5 can suppress hepatitis C virus (HCV) replication independently of IFN signaling through its C-terminal-deficient domain bound to viral RNA, in which CFAP58-DT plays a role as an assistant. Data suggests that CFAP58-DTenhances the innate immune response to viral infection through the promotion of oligomerization and activation of MDA5. CFAP58-DT is involved in MDA5 activation [1].
Regulation
NA
Diseases
- Viral infection (Hepatitis C) [1]
Expression
The expression of CFAP58-DT is highly consistent with MDA5 expression, indicating that CFAP58-DT may function as a cofactor of MDA5 [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| Semi RT-PCR | 5'-GGGGTACCGGGCAGATGGAGACACCCA- 3' | 5'-CGGGATCCTGGGTTGTTGGAAAATTTGCTCAC- 3'[1] |
Labs working on this lncRNA
- Institute of Pathogen Biology and Immunology of College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China. [1]
- Xiangya School of Public Health, Central South University, Changsha, Hunan, China. [1]
- Research Center of Cancer Prevention & Treatment, Translational Medicine Research Center of Liver Cancer, Hunan Provincial Tumor Hospital, Changsha, China. [1]
References
Sequence
>gi|100505869|ref|NR_108036.1| Homo sapiens CFAP58 divergent transcript (CFAP58-DT), long non-coding RNA
000081 AGCCAAGCAT GGAGAGCCGA GGACTAACGC TTGGAAGGAA ATGTGGACCA GAAGGTTCCG GATGAGGGAA GGACTGGCGG 000160
000161 CTACACTCTG CCTTCCGAGA CAACGAGGAA TAATCTCACT TCAGTCAGTT CAACCCTTGT AAAACAGCTA CTGTGTGCAA 000240
000241 GACACGGAGG GAAAGCTGAA GTAGAGAAAC CACAGACGCT GTCTTCAAAG GGTTTAATCT AATATTAGTG ATGAGAAAAA 000320
000321 TAGGGTGCAG AGCTTAAGGC ATCCTGGAAA AACGTATGTA GCGCCACATC GCGAAAATCT CTCTTCTGGG ACCCCTCTCC 000400
000401 CAAAAACGTT TCTTCGCCCT CTTCTCCCCC TTCTGCCTCC ACTCTTTCTG GACTTCAGAT ATCTTTGAGA AGCCTGGACA 000480
000481 TCAATCTGCT TTAGAAGACT AGAAACTCTG CCTTTATGTC TTTAAGGGAA CAATAGTCCT TAACTTTGAT ACTGTGGCTC 000560
000561 TTTAGCTCTT TTTTTCCCTA TATTTTTTAT ATAGTTTTTT GGTATTATTT AGACCTCCTT AACCCCACGG TCATAAAGGT 000640
000641 ATTCTCCCAT CATTTTTTTC TATCCATTAG CTTCATAGTT TTACTTTTTT ACATTCAGTT ATCTAATCCA TCTGGAGTTC 000720
000721 TCCTTCCCAT ATGGTGTGAG ATAGGGATCT AACTATATTT TTCTCCATGG GGTGAGCAAA TTTTCCAACA ACCCATGTCA 000800
000801 AACAATCCAT TCTTTCCAAA TTGGTTTGGG GAAGTTTCCA AATAGACATG AGTATGTTCT GAGCTCTCTG GTTTGTTCAT 000880
000881 GTGTCAGTAC CACAAGGTTT TGTCACTGTG GGTTTTTAGT TAGTCATCAT GCTTGAAGGG CAAGTTCCCC ATTCCAAATT 000960
000961 CTTCTGTGTT AAGATTGCTT TGTCTATCCA CGGGCCTTTA TCCTCCCTTA TAATGTTTAG AGTAAGTTTG TCAAGTTTAT 001040
001041 GAGAACTGTG TTGGGTTGAT GAATAAATGC AAGGAAAACT GGCAA
